Membrane lipids: where they are and how they behave

Phosphoinositides in cell regulation and membrane dynamics

2006 • 2,604 citations

Molecular Anatomy of a Trafficking Organelle

2006 • 2,278 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Separation of Liquid Phases in Giant Vesicles of Ternary Mixtures of Phospholipids and Cholesterol

2003 • 1,408 citations

Lipid sorting in epithelial cells

1988 • 1,354 citations

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

2006 • 1,316 citations

Biomembranes: molecular structure and function

1989 • 1,257 citations

LMSD: LIPID MAPS structure database

2006 • 1,154 citations

Virus Entry: Open Sesame

2006 • 1,136 citations

Paradigm Shift of the Plasma Membrane Concept from the Two-Dimensional Continuum Fluid to the Partitioned Fluid: High-Speed Single-Molecule Tracking of Membrane Molecules

2005 • 1,086 citations

Lipid rafts: at a crossroad between cell biology and physics

2007 • 1,072 citations

Molecular machinery for non-vesicular trafficking of ceramide

2003 • 994 citations

Biomembranes

1989 • 983 citations

Nanoscale Organization of Multiple GPI-Anchored Proteins in Living Cell Membranes

2004 • 865 citations

Lipids of mitochondria

1985 • 842 citations

Bilayer Thickness and Membrane Protein Function: An Energetic Perspective

2007 • 808 citations

Lipid rafts: contentious only from simplistic standpoints

2006 • 769 citations

Role of LBPA and Alix in Multivesicular Liposome Formation and Endosome Organization

2004 • 671 citations

A Microscopic Interaction Model of Maximum Solubility of Cholesterol in Lipid Bilayers

1999 • 585 citations

Ultrastructural localization of gangliosides; GM1 is concentrated in caveolae.

1994 • 506 citations

Cellular lipidomics

2005 • 504 citations

Role of curvature and phase transition in lipid sorting and fission of membrane tubules

2005 • 466 citations

Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals

2006 • 455 citations

Liquid Domains in Vesicles Investigated by NMR and Fluorescence Microscopy

2004 • 453 citations

The function of tight junctions in maintaining differences in lipid composition between the apical and the basolateral cell surface domains of MDCK cells.

1986 • 446 citations

Basalts and Phase Diagrams

1980 • 437 citations

PRINCIPLES OF LYSOSOMAL MEMBRANE DIGESTION: Stimulation of Sphingolipid Degradation by Sphingolipid Activator Proteins and Anionic Lysosomal Lipids

2005 • 432 citations

A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins.

1994 • 431 citations

Lipids in biological membrane fusion

1995 • 431 citations

Relationship of Lipid Rafts to Transient Confinement Zones Detected by Single Particle Tracking

2002 • 418 citations

Ternary Phase Diagram of Dipalmitoyl-PC/Dilauroyl-PC/Cholesterol: Nanoscopic Domain Formation Driven by Cholesterol

2001 • 417 citations

Separation and Characterization of Late Endosomal Membrane Domains

2002 • 386 citations

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

2007 • 383 citations

Molecular Dynamics and Interactions for Creation of Stimulation‐Induced Stabilized Rafts from Small Unstable Steady‐State Rafts

2004 • 368 citations

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

2006 • 367 citations

Drs2p-related P-type ATPases Dnf1p and Dnf2p Are Required for Phospholipid Translocation across the Yeast Plasma Membrane and Serve a Role in Endocytosis

2003 • 353 citations

Lateral Pressure Profile, Spontaneous Curvature Frustration, and the Incorporation and Conformation of Proteins in Membranes

2007 • 333 citations

Partitioning of Thy-1, GM1, and cross-linked phospholipid analogs into lipid rafts reconstituted in supported model membrane monolayers

2001 • 329 citations

The ins and outs of sphingolipid synthesis

2005 • 314 citations

Ceramide-enriched membrane domains

2005 • 307 citations

Lipid flippases and their biological functions

2006 • 300 citations

Cholesterol and the interaction of proteins with membrane domains

2006 • 293 citations

Molecular structure and function

1991 • 291 citations

Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein

2002 • 280 citations

Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis

2007 • 264 citations

A subfraction of the yeast endoplasmic reticulum associates with the plasma membrane and has a high capacity to synthesize lipids

2001 • 262 citations

Transmembrane Asymmetry and Lateral Domains in Biological Membranes

2004 • 255 citations

Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein–related proteins and phosphoinositides

2006 • 250 citations

Probing Red Cell Membrane Cholesterol Movement with Cyclodextrin

2002 • 245 citations

Phase equilibriums in binary mixtures of phosphatidylcholine and cholesterol

1981 • 243 citations

Phospholipid Flippases

2006 • 236 citations

Fluorescence quenching of model membranes. 3. Relationship between calcium adenosinetriphosphatase enzyme activity and the affinity of the protein for phosphatidylcholines with different acyl chain characteristics

1981 • 232 citations

Effects of Ceramide on Liquid-Ordered Domains Investigated by Simultaneous AFM and FCS

2006 • 232 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2016 • 226 citations

DETECTING MICRODOMAINS IN INTACT CELL MEMBRANES

2004 • 225 citations

Lipid topogenesis

1981 • 224 citations

Sphingolipid Transport: Rafts and Translocators

2002 • 223 citations

Transport of Newly Synthesized Sterol to the Sterol-Enriched Plasma Membrane Occurs via Nonvesicular Equilibration

2005 • 221 citations

Measurement of Spontaneous Transfer and Transbilayer Movement of BODIPY-Labeled Lipids in Lipid Vesicles

1997 • 219 citations

Glycosphingolipids Internalized via Caveolar-related Endocytosis Rapidly Merge with the Clathrin Pathway in Early Endosomes and Form Microdomains for Recycling

2003 • 216 citations

Transbilayer Effects of Raft-Like Lipid Domains in Asymmetric Planar Bilayers Measured by Single Molecule Tracking

2006 • 215 citations

The Major Sites of Cellular Phospholipid Synthesis and Molecular Determinants of Fatty Acid and Lipid Head Group Specificity

2002 • 214 citations

A phosphatidic acid-binding protein of the chloroplast inner envelope membrane involved in lipid trafficking

2006 • 210 citations

Influence of pH gradients on the transbilayer transport of drugs, lipids, peptides and metal ions into large unilamellar vesicles

1997 • 210 citations

Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells

2007 • 208 citations

Sphingomyelin Hydrolysis to Ceramide during the Execution Phase of Apoptosis Results from Phospholipid Scrambling and Alters Cell-Surface Morphology

2000 • 200 citations

Closed-Loop Miscibility Gap and Quantitative Tie-Lines in Ternary Membranes Containing Diphytanoyl PC

2006 • 197 citations

Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function

2004 • 194 citations

Flippases and vesicle-mediated protein transport

2004 • 185 citations

Closer Look at Structure of Fully Hydrated Fluid Phase DPPC Bilayers

2006 • 180 citations

UDP-Galactose:Ceramide Galactosyltransferase Is a Class I Integral Membrane Protein of the Endoplasmic Reticulum

1998 • 179 citations

Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function

2005 • 163 citations

Phase coexistence and connectivity in the apical membrane of polarized epithelial cells

2006 • 162 citations

Phase Boundaries and Biological Membranes

2007 • 158 citations

Loss of P4 ATPases Drs2p and Dnf3p Disrupts Aminophospholipid Transport and Asymmetry in Yeast Post-Golgi Secretory Vesicles

2006 • 154 citations

Order from disorder, corralling cholesterol with chaotic lipids

2004 • 153 citations

Membrane lipids as signaling molecules

2007 • 153 citations

Detergent-Resistant, Ceramide-Enriched Domains in Sphingomyelin/Ceramide Bilayers

2005 • 149 citations

Two distinct but interchangeable mechanisms for flipping of lipid-linked oligosaccharides

2006 • 149 citations

Intracellular transport of phosphatidylcholine to the plasma membrane.

1985 • 145 citations

Lipid rafts, fluid/fluid phase separation, and their relevance to plasma membrane structure and function

2007 • 145 citations

Cholesterol Does Not Induce Segregation of Liquid-Ordered Domains in Bilayers Modeling the Inner Leaflet of the Plasma Membrane

2001 • 144 citations

START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells

2003 • 143 citations

Phase behavior of lipid mixtures

2006 • 140 citations

Different Sphingolipids Show Differential Partitioning into Sphingolipid/Cholesterol-Rich Domains in Lipid Bilayers

2000 • 136 citations

Rapid Transbilayer Movement of Ceramides in Phospholipid Vesicles and inHumanErythrocytes

2005 • 134 citations

Brefeldin A does not inhibit the movement of phosphatidylethanolamine from its sites for synthesis to the cell surface

1991 • 131 citations

Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance

2007 • 128 citations

Bridging gaps in phospholipid transport

2005 • 127 citations

Palmitoylation and Intracellular Domain Interactions Both Contribute to Raft Targeting of Linker for Activation of T Cells

2005 • 126 citations

Effect of the Structure of Lipids Favoring Disordered Domain Formation on the Stability of Cholesterol-Containing Ordered Domains (Lipid Rafts): Identification of Multiple Raft-Stabilization Mechanisms

2007 • 124 citations

ABC lipid transporters: Extruders, flippases, or flopless activators?

2005 • 120 citations

Rapid appearance of newly synthesized phosphatidylethanolamine at the plasma membrane.

1983 • 119 citations

Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization

2007 • 118 citations

C. elegans mitochondrial factor WAH-1 promotes phosphatidylserine externalization in apoptotic cells through phospholipid scramblase SCRM-1

2007 • 117 citations

Transport of newly synthesized glucosylceramide to the plasma membrane by a non-Golgi pathway.

1994 • 112 citations

Lysophosphatidylcholine Metabolism in Saccharomyces cerevisiae

2007 • 112 citations

Fluorescence quenching in model membranes. 2. Determination of the local lipid environment of the calcium adenosinetriphosphatase from sarcoplasmic reticulum

1981 • 112 citations

A Genetic Screen for Aminophospholipid Transport Mutants Identifies the Phosphatidylinositol 4-Kinase, Stt4p, as an Essential Component in Phosphatidylserine Metabolism

1998 • 110 citations

Transmembrane movement of phosphatidylglycerol and diacylglycerol sulfhydryl analogs

1984 • 108 citations

Characterization of phosphatidylserine synthesis and translocation in permeabilized animal cells.

1990 • 105 citations

Uptake and Utilization of Lyso-phosphatidylethanolamine by Saccharomyces cerevisiae

2006 • 103 citations

Prefission Constriction of Golgi Tubular Carriers Driven by Local Lipid Metabolism: A Theoretical Model

2003 • 102 citations

Fluorescence Quenching in Model Membranes

1982 • 99 citations

Transbilayer Movement of Phospholipids in Biogenic Membranes

2004 • 96 citations

Evidence for Specificity in Lipid-Rhodopsin Interactions

2006 • 95 citations

The Association of Shiga-like Toxin with Detergent-resistant Membranes Is Modulated by Glucosylceramide and Is an Essential Requirement in the Endoplasmic Reticulum for a Cytotoxic Effect

2005 • 92 citations

Effect of ceramide N-acyl chain and polar headgroup structure on the properties of ordered lipid domains (lipid rafts)

2007 • 92 citations

Lipopolysaccharide Transport to the Bacterial Outer Membrane in Spheroplasts

2004 • 86 citations

Phosphatidylserine Transport to the Mitochondria Is Regulated by Ubiquitination

2002 • 86 citations

The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking

2007 • 74 citations

Ceramide Drives Cholesterol Out of the Ordered Lipid Bilayer Phase into the Crystal Phase in 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/Cholesterol/Ceramide Ternary Mixtures

2006 • 74 citations

Yeast P4-ATPases Drs2p and Dnf1p Are Essential Cargos of the NPFXD/Sla1p Endocytic Pathway

2006 • 70 citations

Flippase Activity Detected with Unlabeled Lipids by Shape Changes of Giant Unilamellar Vesicles

2007 • 69 citations

Aminophospholipid Translocase TAT-1 Promotes Phosphatidylserine Exposure during C. elegans Apoptosis

2007 • 67 citations

Searching for the Molecular Arrangement of Transmembrane Ceramide Channels

2006 • 59 citations

Reconstitution of Phosphatidylserine Transport from Chemically Defined Donor Membranes to Phosphatidylserine Decarboxylase 2 Implicates Specific Lipid Domains in the Process

2004 • 52 citations

Inhibition of caveolar uptake, SV40 infection, and β1-integrin signaling by a nonnatural glycosphingolipid stereoisomer

2007 • 51 citations

Endogenous glycosphingolipids move to the cell surface at a rate consistent with bulk flow estimates.

1992 • 44 citations

Lipid–protein interactions with the Na,K-ATPase

2006 • 41 citations

Characterization of Phosphatidylserine Transport to the Locus of Phosphatidylserine Decarboxylase 2 in Permeabilized Yeast

2001 • 34 citations

Phosphatidylserine decarboxylases as genetic and biochemical tools for studying phospholipid traffic

2005 • 28 citations

Studies of the Minimum Hydrophobicity of α-Helical Peptides Required To Maintain a Stable Transmembrane Association with Phospholipid Bilayer Membranes

2007 • 18 citations

Detection of coexisting fluid phospholipid phases by equilibrium Ca2+ binding: peptide-poor L.alpha. and peptide-rich HII phase coexistence in gramicidin A'/phospholipid dispersions

1994 • 6 citations