Viral Double-Stranded RNA Aggravates Lupus Nephritis through Toll-Like Receptor 3 on Glomerular Mesangial Cells and Antigen-Presenting Cells

Innate Immune Recognition

2002 • 8,157 citations

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

2001 • 5,893 citations

Toll-like receptors: critical proteins linking innate and acquired immunity

2001 • 4,673 citations

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 • 3,745 citations

Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 • 3,104 citations

Toll Pathway-Dependent Blockade of CD4 ⁺ CD25 ⁺ T Cell-Mediated Suppression by Dendritic Cells

2003 • 2,023 citations

Quantitative Expression of Toll-Like Receptor 1–10 mRNA in Cellular Subsets of Human Peripheral Blood Mononuclear Cells and Sensitivity to CpG Oligodeoxynucleotides

2002 • 1,919 citations

Dendritic-cell control of pathogen-driven T-cell polarization

2003 • 1,413 citations

Toll-like receptors control activation of adaptive immune responses

2001 • 1,374 citations

Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?

2002 • 1,343 citations

Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 • 1,246 citations

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 • 1,214 citations

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 • 1,060 citations

Maturation, Activation, and Protection of Dendritic Cells Induced by Double-stranded RNA

1999 • 727 citations

Diffuse proliferative lupus nephritis: Identification of specific pathologic features affecting renal outcome

1984 • 702 citations

Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

2003 • 582 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

2002 • 507 citations

Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling

2002 • 449 citations

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

2004 • 437 citations

Generation of murine dendritic cells from flt3-ligand–supplemented bone marrow cultures

2000 • 422 citations

Quantification of regulatory T cells in patients with systemic lupus erythematosus

2003 • 417 citations

Dendritic cell–induced autoimmune heart failure requires cooperation between adaptive and innate immunity

2003 • 396 citations

Monocyte Chemoattractant Protein 1–Dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in Mrl-Faslpr Mice

1999 • 307 citations

Decreased CD4⁺CD25⁺ T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus

2004 • 286 citations

Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells

2002 • 243 citations

Ligand-regulated Chimeric Receptor Approach Reveals Distinctive Subcellular Localization and Signaling Properties of the Toll-like Receptors

2004 • 235 citations

Chemokine Expression Precedes Inflammatory Cell Infiltration and Chemokine Receptor and Cytokine Expression during the Initiation of Murine Lupus Nephritis

2001 • 234 citations

Activation of toll‐like receptor‐9 induces progression of renal disease in MRL‐Fas(lpr) mice

2004 • 210 citations

Activation of antigen-presenting cells by microbial products breaks self tolerance and induces autoimmune disease

2004 • 198 citations

Toll‐Like Receptor 3: A Link between Toll‐Like Receptor, Interferon and Viruses

2004 • 190 citations

The central role of dendritic cells and interferon-α in SLE

2003 • 163 citations

IL-12 Deficiency in MRL-FaslprMice Delays Nephritis and Intrarenal IFN-γ Expression, and Diminishes Systemic Pathology

2003 • 149 citations

Role of Natural Interferon-α Producing Cells (Plasmacytoid Dendritic Cells) in Autoimmunity

2003 • 138 citations

Modulating Th1/Th2 Responses With Microbes, Dendritic Cells, and Pathogen Recognition Receptors

2004 • 138 citations

Toll-like receptors: balancing host resistance with immune tolerance

2003 • 136 citations

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice.

1996 • 128 citations

Natural Interferon-α Producing Cells: The Plasmacytoid Dendritic Cells

2002 • 122 citations

Role of interleukin-6 in the progression of mesangial proliferative glomerulonephritis.

1993 • 115 citations

Bacterial CpG-DNA Aggravates Immune Complex Glomerulonephritis

2003 • 105 citations

The polymorphism of monocyte chemoattractant protein-1 is associated with the renal disease of SLE

2002 • 99 citations

IL-12 drives IFN-gamma-dependent autoimmune kidney disease in MRL-Fas(lpr) mice.

1999 • 90 citations

Can immunization precipitate connective tissue disease?Report of five cases of systemic lupus erythematosus and review of the literature

1999 • 88 citations

A role for Toll in autoimmunity

2002 • 82 citations

Toll-like receptors and innate antiviral responses

2003 • 69 citations

Expression of the chemokines MCP-1/CCL2 and RANTES/CCL5 is differentially regulated by infiltrating inflammatory cells

2002 • 59 citations

Regulation of RANTES and ICAM-1 expression in murine mesangial cells.

1997 • 55 citations

Antigen processing and presentation by glomerular visceral epithelium in vitro

1991 • 43 citations

Monocyte chemoattractant protein-1 expression in renal tissue is associated with monocyte recruitment and tubulo-interstitial lesions in patients with lupus nephritis.

2001 • 28 citations

Immunoregulatory T cells in autoimmunity

2003 • 25 citations