HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

The Danger Model: A Renewed Sense of Self

2002 • 4,107 citations

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

2002 • 4,011 citations

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

1999 • 3,314 citations

High-mobility group box 1 protein (HMGB1): nuclear weapon in the immune arsenal

2005 • 2,372 citations

Decoding the Patterns of Self and Nonself by the Innate Immune System

2002 • 2,096 citations

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 • 1,306 citations

Pattern Recognition Receptors

2002 • 1,139 citations

Reversing established sepsis with antagonists of endogenous high-mobility group box 1

2003 • 1,105 citations

Toll-like receptors in systemic autoimmune disease

2006 • 1,079 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

2002 • 949 citations

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

2006 • 802 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

TLR4 activation mediates kidney ischemia/reperfusion injury

2007 • 796 citations

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

2005 • 794 citations

Ischemic acute renal failure: An inflammatory disease?

2004 • 743 citations

Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation

2000 • 687 citations

HMGB1 release induced by liver ischemia involves Toll-like receptor 4–dependent reactive oxygen species production and calcium-mediated signaling

2007 • 589 citations

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney

2005 • 544 citations

The cytokine activity of HMGB1

2005 • 529 citations

The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism

2005 • 512 citations

Endogenous ligands of Toll-like receptors: implications for regulating inflammatory and immune responses

2002 • 495 citations

A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA

2007 • 446 citations

Predominant role for C5b-9 in renal ischemia/reperfusion injury

2000 • 443 citations

In Vivo Expression of Toll-Like Receptor 2 and 4 by Renal Epithelial Cells: IFN-γ and TNF-α Mediated Up-Regulation During Inflammation

2002 • 431 citations

Signaling Danger

2004 • 352 citations

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

2009 • 327 citations

Chronic Allograft Nephropathy: Current Concepts and Future Directions

2006 • 326 citations

Macrophages contribute to the initiation of ischaemic acute renal failure in rats

2006 • 317 citations

TLR2 Is Constitutively Expressed within the Kidney and Participates in Ischemic Renal Injury through Both MyD88-Dependent and -Independent Pathways

2007 • 267 citations

HMGB1 contributes to the development of acute lung injury after hemorrhage

2005 • 252 citations

MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells

1990 • 246 citations

Nonhistone Proteins HMG ₁ and HMG ₂ Change the DNA Helical Structure

1978 • 243 citations

Complement Factor C5a Mediates Renal Ischemia-Reperfusion Injury Independent from Neutrophils

2003 • 242 citations

EFFECTS OF INITIAL ISCHEMIA/REPERFUSION INJURY ON THE TRANSPLANTED KIDNEY1

1997 • 237 citations

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

2008 • 227 citations

Anti-HMGB1 Neutralizing Antibody Ameliorates Gut Barrier Dysfunction and Improves Survival after Hemorrhagic Shock

2006 • 219 citations

Toll-like receptor 9 inhibition confers protection from liver ischemia-reperfusion injury

2009 • 189 citations

Ischemia-Reperfusion Injury Activates Innate Immunity in Rat Kidneys

2005 • 185 citations

Blockade of high mobility group box-1 protein attenuates experimental severe acute pancreatitis

2006 • 132 citations

Hemorrhage-induced acute lung injury is TLR-4 dependent

2004 • 132 citations

Cutting Edge: High-Mobility Group Box 1 Preconditioning Protects against Liver Ischemia-Reperfusion Injury

2006 • 114 citations

High Mobility Group Protein 1 (HMGB1) Quantified by ELISA with a Monoclonal Antibody That Does Not Cross-React with HMGB2

2003 • 104 citations

Anti‐High‐Mobility Group Box Chromosomal Protein 1 Antibodies Improve Survival of Rats with Sepsis

2006 • 103 citations

Resident Dendritic Cells Prevent Postischemic Acute Renal Failure by Help of Single Ig IL-1 Receptor-Related Protein

2009 • 91 citations

Do Alloreactivity and Prolonged Cold Ischemia Cause Different Elementary Lesions in Chronic Allograft Nephropathy?

2003 • 74 citations

The Toll-IL-1R Member Tir8/SIGIRR Negatively Regulates Adaptive Immunity against Kidney Grafts

2009 • 50 citations

Heat Shock Protein gp96 Interacts with Protein Phosphatase 5 and Controls Toll-like Receptor 2 (TLR2)-mediated Activation of Extracellular Signal-regulated Kinase (ERK) 1/2 in Post-hypoxic Kidney Cells

2009 • 45 citations