Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

2000 • 4,169 citations

Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence.

1986 • 1,078 citations

The nucleotide sequence of the rat cytoplasmic β–actin gene

1983 • 1,059 citations

Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

2001 • 1,048 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?

1999 • 623 citations

Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces.

1992 • 459 citations

The Spontaneously Diabetic Wistar Rat: Metabolic and Morphologic Studies

1977 • 409 citations

Osteopontin—a molecule for all seasons

2002 • 385 citations

Angiotensin II-induced hypertrophy of cultured murine proximal tubular cells is mediated by endogenous transforming growth factor-beta.

1993 • 381 citations

Isolation of a pure suspension of rat proximal tubules

1981 • 349 citations

Expression, roles, receptors, and regulation of osteopontin in the kidney

2001 • 339 citations

cDNA cloning by PCR of rat transforming growth factor β-1

1990 • 274 citations

The spontaneously diabetic Wistar rat (the ?BB? rat)

1978 • 267 citations

Osteopontin expression in angiotensin II-induced tubulointerstitial nephritis

1994 • 228 citations

Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy

2004 • 193 citations

Experimental Models of Diabetes

2018 • 191 citations

Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse

1994 • 186 citations

High Glucose Stimulates Angiotensinogen Gene Expression via Reactive Oxygen Species Generation in Rat Kidney Proximal Tubular Cells

2002 • 184 citations

Tubulointerstitial disease in glomerulonephritis. Potential role of osteopontin (uropontin).

1994 • 163 citations

Molecular Profiling of Diabetic Mouse Kidney Reveals Novel Genes Linked to Glomerular Disease

2004 • 151 citations

Diabetic nephropathy: the central role of renal proximal tubular cells in tubulointerstitial injury.

2002 • 144 citations

Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ε) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ

1999 • 118 citations

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells

1999 • 117 citations

Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes.

1998 • 116 citations

Effects of transiently expressed atypical (ζ, λ), conventional (α, β) and novel (δ, ɛ) protein kinase C isoforms on insulin-stimulated translocation of epitope-tagged GLUT4 glucose transporters in rat adipocytes: specific interchangeable effects of protein kinases C-ζ and C-λ

1999 • 110 citations

Therapy with antisense TGF-β1 oligodeoxynucleotides reduces kidney weight and matrix mRNAs in diabetic mice

2000 • 105 citations

Hypoxia Stimulates Osteopontin Expression and Proliferation of Cultured Vascular Smooth Muscle Cells

2001 • 94 citations

High Glucose Stimulates Angiotensinogen Gene Expression and Cell Hypertrophy via Activation of the Hexosamine Biosynthesis Pathway in Rat Kidney Proximal Tubular Cells

2003 • 90 citations

Protein Kinase Cβ Inhibition Attenuates Osteopontin Expression, Macrophage Recruitment, and Tubulointerstitial Injury in Advanced Experimental Diabetic Nephropathy

2005 • 89 citations

Regulation of angiotensin II‐stimulated osteopontin expression in cardiac microvascular endothelial cells: Role of p42/44 mitogen‐activated protein kinase and reactive oxygen species*

2001 • 78 citations

The role of renal proximal tubular cells in diabetic nephropathy

2003 • 73 citations

Signaling pathways and late-onset gene induction associated with renal mesangial cell hypertrophy

2002 • 71 citations

Gene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis

2001 • 69 citations

Microarray Analysis of Gene Expression in the Kidneys of New- and Post-Onset Diabetic NOD Mice

2003 • 65 citations

Effect of Puberty on Initial Kidney Growth and Rise in Kidney IGF-I in Diabetic Rats

1990 • 62 citations

Osteopontin regulation in cultured rat renal epithelial cells

1997 • 62 citations

Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2)27 rats

2002 • 58 citations

Upregulation of osteopontin expression in renal cortex of streptozotocin-induced diabetic rats is mediated by bradykinin.

1998 • 56 citations

Long-term treatment with ramipril attenuates renal osteopontin expression in diabetic rats

2003 • 51 citations

Increased epidermal growth factor in experimental diabetes related kidney growth in rats

1997 • 50 citations

Regulation of proximal tubular osteopontin in experimental hydronephrosis in the rat

1998 • 49 citations

Angiotensinogen and AT₁antisense inhibition of osteopontin translation in rat proximal tubular cells

2000 • 48 citations

Essential Role(s) of the Intrarenal Renin-Angiotensin System in Transforming Growth Factor–β1 Gene Expression and Induction of Hypertrophy of Rat Kidney Proximal Tubular Cells in High Glucose

2002 • 47 citations

Osteopontin: correlation with interstitial fibrosis in human diabetic kidney and PI3‐kinase‐mediated enhancement of expression by glucose in human proximal tubular epithelial cells

2004 • 44 citations

Gene expression profile in diabetic KK/Ta mice

2003 • 39 citations

Hyperglycemia induces insulin resistance on angiotensinogen gene expression in diabetic rat kidney proximal tubular cells

2002 • 37 citations

Muscle protein catabolism in diabetes: 3-Methylhistidine excretion in the spontaneously diabetic “BB” rat

1980 • 32 citations

Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression

2002 • 24 citations

TPA-mediated regulation of osteopontin in human malignant glioma cells.

1998 • 19 citations

Recommended nomenclature for the spontaneously diabetic syndrome of the BB rat

1983 • 10 citations