The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?

The Effect of Angiotensin-Converting-Enzyme Inhibition on Diabetic Nephropathy

1993 • 5,296 citations

Randomised placebo-controlled trial of effect of ramipril on decline in glomerular filtration rate and risk of terminal renal failure in proteinuric, non-diabetic nephropathy

1997 • 1,775 citations

Structural-functional relationships in diabetic nephropathy.

1984 • 1,202 citations

Tubulointerstitial Changes as a Major Determinant in the Progression of Renal Damage

1992 • 951 citations

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 • 905 citations

Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.

1993 • 819 citations

The case for intrarenal hypertension in the initiation and progression of diabetic and other glomerulopathies

1982 • 807 citations

Transforming Growth Factor‐β

1990 • 696 citations

Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

1996 • 658 citations

Understanding the nature of renal disease progression

1997 • 655 citations

Molecular insights into renal interstitial fibrosis.

1996 • 636 citations

Effect of Antihypertensive Therapy on the Kidney in Patients with Diabetes: A Meta-Regression Analysis

1993 • 612 citations

Pathogenesis, prevention, and treatment of diabetic nephropathy

1998 • 560 citations

Hyperglycemia and Diabetic Kidney Disease: The Case for Transforming Growth Factor–β as a Key Mediator

1995 • 560 citations

Renal injury from angiotensin II-mediated hypertension.

1992 • 546 citations

Early role of Fsp1 in epithelial-mesenchymal transformation

1997 • 433 citations

Salt Induces Myocardial and Renal Fibrosis in Normotensive and Hypertensive Rats

1998 • 340 citations

Angiotensin II as a renal growth factor.

1993 • 311 citations

Leukocyte analysis using monoclonal antibodies in human glomerulonephritis

1987 • 300 citations

Effect of Blood Glucose Control on Increased Glomerular Filtration Rate and Kidney Size in Insulin-Dependent Diabetes

1985 • 269 citations

Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE-peptides by renal proximal tubular cells

1996 • 248 citations

In progressive nephropathies, overload of tubular cells with filtered proteins translates glomerular permeability dysfunction into cellular signals of interstitial inflammation.

1998 • 242 citations

Renal hypertrophy in experimental diabetes

1980 • 239 citations

Renal interstitial expansion in insulin-dependent diabetes mellitus

1993 • 229 citations

Renal catabolism of advanced glycation end products: The fate of pentosidine

1998 • 224 citations

Angiotensin II modulates cell growth-related events and synthesis of matrix proteins in renal interstitial fibroblasts

1997 • 208 citations

Transforming growth factor β1 and renal injury following subtotal nephrectomy in the rat: Role of the renin-angiotensin system

1997 • 206 citations

Expression of transforming growth factor-beta1 and type IV collagen in the renal tubulointerstitium in experimental diabetes: effects of ACE inhibition.

1998 • 203 citations

Effect of Strict Glycemic Control on Renal Hemodynamic Response to Amino Acids and Renal Enlargement in Insulin-Dependent Diabetes Mellitus

1991 • 198 citations

High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule

1990 • 196 citations

Renal hypertrophy is associated with upregulation of TGF-beta 1 gene expression in diabetic BB rat and NOD mouse

1994 • 186 citations

Structure and Function of the Kidney in Diabetic Glomerulosclerosis

1980 • 186 citations

EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II

1987 • 182 citations

Expression of Transforming Growth Factor-β and Type IV Collagen in Early Streptozotocin-Induced Diabetes

1997 • 180 citations

Progressive Decline in Renal Function in Diabetic Patients With and Without Albuminuria

1994 • 175 citations

PDGF and TGF-β mediate collagen production by mesangial cells exposed to advanced glycosylation end products

1995 • 175 citations

Ambulatory Blood Pressure in the Transition from Normo- to Microalbuminuria: A Longitudinal Study in IDDM Patients

1994 • 174 citations

The renal tubulointerstitium in diabetes mellitus

1991 • 169 citations

A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)

1998 • 166 citations

Renal hypertrophy in experimental diabetes mellitus

1983 • 164 citations

Renin expression in renal proximal tubule.

1993 • 161 citations

Effects of aminoguanidine in preventing experimental diabetic nephropathy are related to the duration of treatment

1996 • 160 citations

Renal Hypertrophy in Streptozotocin-Diabetic Rats

1976 • 159 citations

Prevention of diabetic nephropathy in db/db mice with glycated albumin antagonists. A novel treatment strategy.

1995 • 150 citations

Clinical and Histological Correlations of Decline in Renal Function in Diabetic Patients With Proteinuria

1994 • 149 citations

Proximal tubular basement membrane width in insulin-dependent diabetes mellitus

1998 • 143 citations

Renal enlargement: Comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats

1983 • 142 citations

From segmental glomerulosclerosis to total nephron degeneration and interstitial fibrosis: a histopathological study in rat models and human glomerulopathies

1998 • 142 citations

Sequential renal biopsies in insulin-dependent diabetic patients: Structural factors associated with clinical progression

1995 • 141 citations

Paracrine stimulation of human renal fibroblasts by proximal tubule cells

1998 • 139 citations

Hypothesis: The role of acquired tubulointerstitial disease in the pathogenesis of salt-dependent hypertension

1997 • 137 citations

Heterogeneous nature of microalbuminuria in NIDDM: studies of endothelial function and renal structure

1998 • 130 citations

Intermittent high glucose enhances cell growth and collagen synthesis in cultured human tubulointerstitial cells

1999 • 128 citations

ECM gene expression and its modulation by insulin in diabetic rats

1992 • 123 citations

Role of Angiotensin II and Bradykinin in Experimental Diabetic Nephropathy: Functional and Structural Studies

1997 • 123 citations

Morphology of interstitial cells in the healthy kidney

1996 • 121 citations

Glomerular Structure in IDDM Women With Low Glomerular Filtration Rate and Normal Urinary Albumin Excretion

1992 • 120 citations

Molecular mechanisms of glucose action on angiotensinogen gene expression in rat proximal tubular cells

1999 • 117 citations

Atubular glomeruli and the structural basis for chronic renal failure.

1992 • 117 citations

Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes.

1998 • 116 citations

Characterization and distribution of interstitial cell types in the renal cortex of rats

1994 • 114 citations

Gene expression of the renin-angiotensin system in human kidney

1998 • 112 citations

Effects of different antihypertensive treatments on morphologic progression of diabetic nephropathy in uninephrectomized dogs

1994 • 109 citations

Expansion of Cortical Interstitium Is Limited by Converting Enzyme Inhibition in Type 2 Diabetic Patients with Glomerulosclerosis

1999 • 108 citations

Quantitative morphology of the rat kidney

1980 • 106 citations

Protein glycation in the kidney: Role in diabetes and aging

1996 • 105 citations

Transforming Growth Factor β in Diabetic Nephropathy

1996 • 103 citations

Local macrophage and myofibroblast proliferation in progressive renal injury in the rat remnant kidney

1998 • 103 citations

Gene expression for endothelins and their receptors in glomeruli of diabetic rats.

1993 • 100 citations

Long-term glycemic control and the rate of progression of early diabetic kidney disease

1993 • 96 citations

Sodium-hydrogen exchange and glucose transport in renal microvillus membrane vesicles from rats with diabetes mellitus.

1986 • 93 citations

Transforming Growth Factor β in Diabetic Nephropathy

1996 • 85 citations

Tubular Hypermetabolism as a Factor in the Progression of Chronic Renal Failure

1988 • 84 citations

Renal expression of transforming growth factor-β inducible gene-h3 (βig-h3) in normal and diabetic rats

1998 • 81 citations

Contribution of tubular injury to loss of remnant kidney function

1998 • 78 citations

Advanced glycation endproducts stimulate the MAP‐kinase pathway in tubulus cell line LLC‐PK₁

1997 • 77 citations

Effect of diabetes and aminoguanidine therapy on renal advanced glycation end-product binding

1999 • 77 citations

Glomerular Filtration Rate in Streptozocin-Induced Diabetic Rats: Role of Exchangeable Sodium, Vasoactive Hormones, and Insulin Therapy

1990 • 74 citations

The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture

1991 • 72 citations

An aldose reductase inhibitor prevents glucose-induced increase in transforming growth factor-? and protein kinase C activity in cultured human mesangial cells

1998 • 71 citations

Angiotensin II-stimulated expression of transforming growth factor beta in renal proximal tubular cells: Attenuation after stable transfection with the c-mas oncogene

1995 • 70 citations

Early increased renal procollagen α1(IV) mRNA levels in streptozotocin induced diabetes

1992 • 69 citations

Acute effects of streptozotocin diabetes on rat renal function.

1979 • 68 citations

Immunocytochemical detection of advanced glycated end products in rat renal tissue as a function of age and diabetes

1998 • 66 citations

DIABETIC VASCULAR COMPLICATIONS

1997 • 66 citations

Effect of Puberty on Initial Kidney Growth and Rise in Kidney IGF-I in Diabetic Rats

1990 • 62 citations

Significance of tubulointerstitial changes in diabetic renal disease.

1996 • 61 citations

Quantitative morphology of the rat kidney during diabetes mellitus and insulin treatment

1997 • 60 citations

Polarity of stimulation and secretion of transforming growth factor-beta 1 by cultured proximal tubular cells.

1997 • 58 citations

Renal proximal tubular cell fibronectin accumulation in response to glucose is polyol pathway dependent

1999 • 56 citations

Role of local and systemic angiotensin in diabetic renal disease.

1997 • 55 citations

Polyol pathway mediates high glucose-induced collagen synthesis in proximal tubule

1994 • 55 citations

On the prognosis of IDDM patients with large kidneys

1998 • 54 citations

Increased epidermal growth factor in experimental diabetes related kidney growth in rats

1997 • 50 citations

Altered Kidney Matrix Gene Expression in Early Stages of Experimental Diabetes

1997 • 50 citations

Differential Distribution of Type IV Collagen Chains in Patients with Diabetic Nephropathy in Non-lnsulin-Dependent Diabetes mellitus

1995 • 47 citations

Effect of glycation of albumin on its renal clearance in normal and diabetic rats

1988 • 43 citations

Prevention of urinary albumin excretion in 6 month streptozocin-diabetic rats with the aldose reductase inhibitor tolrestat

1988 • 41 citations

Demonstration of collagen type VI and alpha-smooth muscle actin in renal fibrotic injury in man.

1998 • 35 citations

Effect of glucose, pyruvate, and insulin on type 1 angiotensin II receptor expression in SV40-immortalized rabbit proximal tubule epithelial cells

1997 • 33 citations

Tubulointerstitial lesions in non-insulin dependent diabetes mellitus.

1997 • 32 citations

Regulation of glomerular and proximal tubule renin mRNA by chronic changes in dietary NaCl

1997 • 31 citations

Recombinant insulin-like growth factor I normalizes expression of renal glucose transporters in diabetic rats

1997 • 27 citations

Zopolrestat Prevention of Proteinuria, Albuminuria and Cataractogenesis in Diabetes mellitus

1996 • 24 citations

Differential regulation of rat glomerular and proximal tubular renin mRNA following uninephrectomy

1996 • 21 citations

Decrease of Renal Endothelin 1 Content and Gene Expression in Diabetic Rats with Moderate Hyperglycemia

1995 • 17 citations

Renal hypertrophy as a prognostic index for the progression of diabetic renal disease in non-insulin-dependent diabetes mellitus

1993 • 15 citations

Human urinary intestinal alkaline phosphatase as an indicator of S3-segment-specffic alterations in incipient diabetic nephropathy

1994 • 14 citations

French and German Nephrologists in the Mid-19th Century

1989 • 8 citations

Differential regulation of rat glomerular and proximal tubular renin mRNA following uninephrectomy

1996 • 7 citations

Deleted Work

1955 • 0 citations