Novel Nox inhibitor VAS2870 attenuates PDGF-dependent smooth muscle cell chemotaxis, but not proliferation☆

Endothelial Dysfunction in Cardiovascular Diseases: The Role of Oxidant Stress

2000 • 3,760 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

The smooth muscle cell in culture

1979 • 1,546 citations

Cell transformation by the superoxide-generating oxidase Mox1

1999 • 1,457 citations

Vascular NAD(P)H oxidases: specific features, expression, and regulation

2003 • 1,029 citations

Novel gp91 ^phox Homologues in Vascular Smooth Muscle Cells

2001 • 841 citations

Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002 • 838 citations

Identification of Renox, an NAD(P)H oxidase in kidney

2000 • 824 citations

Homologs of gp91 phox : cloning and tissue expression of Nox3, Nox4, and Nox5

2001 • 794 citations

The superoxide-generating NADPH oxidase: structural aspects and activation mechanism

2002 • 753 citations

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

2002 • 719 citations

The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases

2003 • 691 citations

Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.

1994 • 647 citations

Novel Competitive Inhibitor of NAD(P)H Oxidase Assembly Attenuates Vascular O ₂ ⁻ and Systolic Blood Pressure in Mice

2001 • 598 citations

A gp91phox Containing NADPH Oxidase Selectively Expressed in Endothelial Cells Is a Major Source of Oxygen Radical Generation in the Arterial Wall

2000 • 596 citations

Expression of a Functionally Active gp91phox-Containing Neutrophil-Type NAD(P)H Oxidase in Smooth Muscle Cells From Human Resistance Arteries

2002 • 589 citations

NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat

2001 • 343 citations

Activation of NADPH Oxidase in Alzheimer's Disease Brains

2000 • 286 citations

Overexpression of Human Catalase Inhibits Proliferation and Promotes Apoptosis in Vascular Smooth Muscle Cells

1999 • 214 citations

Inhibition of Vascular Endothelial Growth Factor-Induced Angiogenesis by Resveratrol through Interruption of Src-Dependent Vascular Endothelial Cadherin Tyrosine Phosphorylation

2003 • 206 citations

Diphenyleneiodonium inhibits reduction of iron-sulfur clusters in the mitochondrial NADH-ubiquinone oxidoreductase (Complex I).

1994 • 199 citations

Inhibition of NADPH Oxidase Activation by 4-(2-Aminoethyl)-benzenesulfonyl Fluoride and Related Compounds

1997 • 196 citations

NAD(P)H Oxidase 1, a Product of Differentiated Colon Epithelial Cells, Can Partially Replace Glycoprotein 91phox in the Regulated Production of Superoxide by Phagocytes

2003 • 190 citations

An NAD(P)H oxidase regulates growth and transcription in melanoma cells

2002 • 171 citations

Phosphoinositide-Dependent Kinase 1 and p21-Activated Protein Kinase Mediate Reactive Oxygen Species–Dependent Regulation of Platelet-Derived Growth Factor–Induced Smooth Muscle Cell Migration

2004 • 162 citations

A central role for the endothelial NADPH oxidase in atherosclerosis

2000 • 147 citations

Novel NAD(P)H Oxidase Inhibitor Suppresses Angioplasty-Induced Superoxide and Neointimal Hyperplasia of Rat Carotid Artery

2003 • 142 citations

Protein Kinase B Activation by Reactive Oxygen Species Is Independent of Tyrosine Kinase Receptor Phosphorylation and Requires Src Activity

2003 • 118 citations

NADPH oxidase promotes NF-κB activation and proliferation in human airway smooth muscle

2002 • 112 citations

A Dual Inhibitor of Platelet-Derived Growth Factor β-Receptor and Src Kinase Activity Potently Interferes With Motogenic and Mitogenic Responses to PDGF in Vascular Smooth Muscle Cells

1999 • 112 citations

Inhibition of the PDGF receptor by red wine flavonoids provides a molecular explanation for the “French paradox”

2002 • 111 citations

Effects of apocynin, a drug isolated from the roots of Picrorhiza kurroa, on arachidonic acid metabolism

1992 • 104 citations

Cytochromeb₅₅₈–Dependent NAD(P)H Oxidase–Phox Units in Smooth Muscle and Macrophages of Atherosclerotic Lesions

2002 • 102 citations

Hydrogen Peroxide Formation by Cells Treated with a Tumor Promoter

1991 • 91 citations

Identification of the Receptor-associated Signaling Enzymes That Are Required for Platelet-derived Growth Factor-AA-dependent Chemotaxis and DNA Synthesis

1999 • 87 citations

Apocynin increases glutathione synthesis and activates AP‐1 in alveolar epithelial cells

1999 • 79 citations

Interactions between the Cytosolic Components p47 and p67 of the Human Neutrophil NADPH Oxidase That Are Not Required for Activation in the Cell-free System

1995 • 78 citations

Reactive oxygen species-sensitive p38 MAPK controls thrombin-induced migration of vascular smooth muscle cells

2003 • 75 citations

Native LDL Induces Proliferation of Human Vascular Smooth Muscle Cells via Redox-Mediated Activation of ERK 1/2 Mitogen-Activated Protein Kinases

2002 • 67 citations

Signaling Events Mediating the Additive Effects of Oleic Acid and Angiotensin II on Vascular Smooth Muscle Cell Migration

2001 • 62 citations

Mycophenolic Acid Inhibits Platelet-Derived Growth Factor-Induced Reactive Oxygen Species and Mitogen-Activated Protein Kinase Activation in Rat Vascular Smooth Muscle Cells

2004 • 54 citations

Role of reactive oxygen species in bradykinin-induced proliferation of vascular smooth muscle cells

2004 • 44 citations

Nitric oxide synthase and NAD(P)H oxidase modulate coronary endothelial cell growth

2003 • 21 citations

Cyclin E and cyclin A are likely targets of Src for PDGF‐induced DNA synthesis in fibroblasts

2002 • 13 citations