Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3)

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Matrix Metalloproteinases: A Review

1993 • 2,998 citations

Tissue inhibitors of metalloproteinases: evolution, structure and function

2000 • 1,873 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

The matrix‐degrading metalloproteinases

1992 • 1,383 citations

Matrix Metalloproteinase-2 Is an Interstitial Collagenase

1995 • 917 citations

Matrix metalloproteinase degradation of extracellular matrix: biological consequences

1998 • 726 citations

Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

1994 • 660 citations

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 • 604 citations

Human 92- and 72-kilodalton type IV collagenases are elastases.

1991 • 550 citations

Molecular Cloning and Characterization of Human Tissue Inhibitor of Metalloproteinase 4

1996 • 547 citations

Two distinct phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways

1996 • 538 citations

ECM signalling: orchestrating cell behaviour and misbehaviour

1998 • 537 citations

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

2001 • 493 citations

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 • 485 citations

ADAMs: focus on the protease domain

1998 • 472 citations

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

1998 • 468 citations

Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution.

1992 • 445 citations

Expression of matrix metalloproteinase-2 and -9 during early human wound healing.

1994 • 411 citations

Shedding of Syndecan-1 and -4 Ectodomains Is Regulated by Multiple Signaling Pathways and Mediated by a Timp-3–Sensitive Metalloproteinase

2000 • 409 citations

Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

2000 • 407 citations

The in vitro activity of ADAM‐10 is inhibited by TIMP‐1 and TIMP‐3

2000 • 396 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema

1992 • 378 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Expression and function of matrix metalloproteinases and their inhibitors at the maternal-embryonic boundary during mouse embryo implantation

1996 • 345 citations

TIMP-3 Binds to Sulfated Glycosaminoglycans of the Extracellular Matrix

2000 • 323 citations

ADAM 12-S Cleaves IGFBP-3 and IGFBP-5 and Is Inhibited by TIMP-3

2000 • 309 citations

The Gene Structure of Tissue Inhibitor of Metalloproteinases (TIMP)-3 and Its Inhibitory Activities Define the Distinct TIMP Gene Family

1995 • 295 citations

Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3

1999 • 285 citations

A new inhibitor of metalloproteinases from chicken: ChIMP-3. A third member of the TIMP family.

1992 • 274 citations

Remodeling of human myocardial collagen in idiopathic dilated cardiomyopathy. Role of metalloproteinases and pyridinoline cross-links.

1996 • 274 citations

Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.

1998 • 268 citations

Collagen polymorphism in the lungAn immunochemical study of pulmonary fibrosis

1980 • 220 citations

Inhibition of Late Vein Graft Neointima Formation in Human and Porcine Models by Adenovirus-Mediated Overexpression of Tissue Inhibitor of Metalloproteinase-3

2000 • 208 citations

Murine tissue inhibitor of metalloproteinases—4 (Timp—4): cDNA isolation and expression in adult mouse tissues¹

1997 • 192 citations

Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor

1995 • 192 citations

TIMP-3 INDUCES CELL DEATH BY STABILIZING TNF-α RECEPTORS ON THE SURFACE OF HUMAN COLON CARCINOMA CELLS

1997 • 190 citations

Inhibition of ADAMTS4 (aggrecanase‐1) by tissue inhibitors of metalloproteinases (TIMP‐1, 2, 3 and 4)

2001 • 181 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 164 citations

Microassay for the Assessment of Low Levels of Hydroxyproline

1997 • 155 citations

Inactivating Mutation of the Mouse Tissue Inhibitor of Metalloproteinases-2(Timp-2) Gene Alters ProMMP-2 Activation

2000 • 147 citations

Suppression of in vivo tumor growth and induction of suspension cell death by tissue inhibitor of metalloproteinases (TIMP)-3

1996 • 146 citations

Accelerated apoptosis in the Timp-3–deficient mammary gland

2001 • 144 citations

Role of the 21-kDa protein TIMP-3 in oncogenic transformation of cultured chicken embryo fibroblasts.

1992 • 137 citations

Gene encoding a novel murine tissue inhibitor of metalloproteinases (TIMP), TIMP‐3, is expressed in developing mouse epithelia, cartilage, and muscle, and is located on mouse chromosome 10

1994 • 135 citations

Tissue Inhibitor of Metalloproteinases-3 Inhibits Shedding of L-selectin from Leukocytes

1999 • 126 citations

92‐kDa type IV collagenase and TIMP‐3, but not 72‐kDa type IV collagenase or TIMP‐1 or TIMP‐2, are highly expressed during mouse embryo implantation

1995 • 125 citations

Effects of Gene Deletion of the Tissue Inhibitor of the Matrix Metalloproteinase-type 1 (TIMP-1) on Left Ventricular Geometry and Function in Mice

2000 • 125 citations

Localization of the Death Domain of Tissue Inhibitor of Metalloproteinase-3 to the N Terminus

2000 • 123 citations

TIMP-1 Deficiency Does Not Attenuate Interstitial Fibrosis in Obstructive Nephropathy

2001 • 122 citations

Targeted mutagenesis of Timp-1 reveals that lung tumor invasion is influenced by Timp-1 genotype of the tumor but not by that of the host.

1996 • 121 citations

Timp-1 Is Important for Epithelial Proliferation and Branching Morphogenesis during Mouse Mammary Development

1999 • 114 citations

Interstitial fibrosis in mice with overload proteinuria: Deficiency of TIMP-1 is not protective

2000 • 113 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2014 • 112 citations

Shedding of c-Met is regulated by crosstalk between a G-protein coupled receptor and the EGF receptor and is mediated by a TIMP-3 sensitive metalloproteinase

2001 • 105 citations

Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell line

1998 • 98 citations

Differential regulation of TIMP-1 and TIMP-2 mRNA expression in normal and Ha-ras-transformed murine fibroblasts

1992 • 96 citations

Human myeloma cells shed the interleukin‐6 receptor: inhibition by tissue inhibitor of metalloproteinase‐3 and a hydroxamate‐based metalloproteinase inhibitor

1998 • 94 citations

Altered Tumor Growth and Metastasis of a T-Cell Lymphoma in Timp-1 Transgenic Mice

1997 • 90 citations

Tissue Inhibitor of Matrix Metalloproteinases-1 Impairs Arterial Neointima Formation After Vascular Injury in Mice

1999 • 89 citations

Tobacco smoke-induced lung emphysema in guinea pigs is associated with increased interstitial collagenase

1996 • 82 citations

Assessment of the Role of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) during the Periovulatory Period in Female Mice Lacking a Functional TIMP-1 Gene1

1997 • 75 citations

Disruption of the Tissue Inhibitor of Metalloproteinase-1 Gene Results in Altered Reproductive Cyclicity and Uterine Morphology in Reproductive-Age Female Mice1

2000 • 72 citations

Quantitation of Types I and III Collagen in Biopsy Lung Samples from Patients with Cryptogenic Fibrosing Alveolitis

1984 • 68 citations

TIMP-1 promotes VEGF-induced neovascularization in the retina.

2001 • 68 citations

Tissue inhibitor of metalloproteinases-3 is the major metalloproteinase inhibitor in the decidualizing murine uterus

1996 • 67 citations

Smoke-induced emphysema in guinea pigs is associated with morphometric evidence of collagen breakdown and repair

1995 • 65 citations

Molecular Cloning of Mouse Tissue Inhibitor of Metalloproteinases-3 and Its Promoter

1995 • 63 citations

Temporal and Spatial Expression of Tissue Inhibitors of Metalloproteinases during the Natural Ovulatory Cycle of the Mouse1

1996 • 60 citations

Full-Length and N-TIMP-3 Display Equal Inhibitory Activities toward TNF-α Convertase

2001 • 59 citations

Expression and Activity of Ovarian Tissue Inhibitors of Metalloproteinases during Pseudopregnancy in the Rat1

1995 • 58 citations

Transformation-sensitive protein associated with the cell substratum of chicken embryo fibroblasts

1983 • 50 citations

A microassay for elastin

1973 • 47 citations

Age-related Changes in Lung Collagen Metabolism: A Role for Degradation in Regulating Lung Collagen Production

1989 • 46 citations

Pattern of Messenger Ribonucleic Acid Expression of Tissue Inhibitors of Metalloproteinases (TIMPs) during Testicular Maturation in Male Mice Lacking a Functional TIMP-1 Gene1

1998 • 35 citations

Ultrastructural alterations in collagen associated with microscopic foci of human emphysema

1977 • 28 citations

Temporospatial expression of tissue inhibitors of matrix metalloproteinases-1, -2 and -3 during development, growth and aging of the mouse skeleton

2000 • 27 citations

Induction of tissue inhibitor of metalloproteinases-3 is a delayed early cellular response to hepatocyte growth factor

1998 • 26 citations

A technique for measuring carbon monoxide uptake in mice

1981 • 20 citations

Incorporation of Fluorescent Enzyme Substrates in Agarose Gel for in Situ Zymography

2001 • 17 citations

Hyper‐resistance to Infection in TIMP‐1‐Deficient Mice Is Neutrophil Dependent but Not Immune Cell Autonomous

1999 • 17 citations

Animal models and acute and long-term carbon monoxide intoxication

1979 • 15 citations