Characterization of T Cell Differentiation in the Murine Gut

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

A Direct Estimate of the Human αβ T Cell Receptor Diversity

1999 • 893 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

Response of naïve and memory CD8+ T cells to antigen stimulation in vivo

2000 • 542 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Early T Lymphocyte Progenitors

1996 • 473 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Identification of a Committed Precursor for the Mast Cell Lineage

1996 • 379 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

1998 • 301 citations

Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

1996 • 294 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

Two waves of recombinase gene expression in developing thymocytes.

1994 • 268 citations

In Vivo Modulation of Cytolytic Activity and Thy-1 Expression In TCR-γδ ⁺ Intraepithelial Lymphocytes

1989 • 258 citations

Diversity of γδ T-cell receptors on murine intestinal intraepithelial lymphocytes

1989 • 217 citations

Thymic and extrathymic origins of gut intraepithelial lymphocyte populations in mice.

1994 • 208 citations

Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.

1994 • 206 citations

Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-γ, TNF) in the induction of epithelial cell death and renewal

1998 • 202 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Gut mucosal mast cells. Origin, traffic, and differentiation.

1984 • 170 citations

Characterization of TCR Gene Rearrangements During Adult Murine T Cell Development

1999 • 160 citations

Gut Cryptopatches

2000 • 147 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

Oligoclonal repertoire of the CD8 alpha alpha and the CD8 alpha beta TCR-alpha/beta murine intestinal intraepithelial T lymphocytes: evidence for the random emergence of T cells.

1994 • 130 citations

Extrathymic T cell differentiation

1995 • 129 citations

T cells orchestrate intestinal mucosal shape and integrity

1999 • 126 citations

Complexity of the mouse gut T cell immune system: Identification of two distinct natural killer T cell intraepithelial lineages

1996 • 120 citations

Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.

1994 • 120 citations

Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene

1995 • 109 citations

Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment

1998 • 107 citations

Identical T Cell Clones Are Located within the Mouse Gut Epithelium and Lamina Propria and Circulate in the Thoracic Duct Lymph

2000 • 106 citations

On the Role of the Pre–T Cell Receptor in αβ versus γδ T Lineage Commitment

1998 • 96 citations

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

1993 • 94 citations

Stable and functional lymphoid reconstitution of common cytokine receptor γ chain deficient mice by retroviral-mediated gene transfer

2000 • 89 citations

Functional and Molecular Analysis of Hematopoietic Progenitors Derived From the Aorta-Gonad-Mesonephros Region of the Mouse Embryo

1999 • 80 citations

CD3⁻CD8⁺ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL

1994 • 78 citations

Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.

1996 • 76 citations

Regulation of RAG expression in developing lymphocytes

2000 • 63 citations

The Neonatal Development of Intraepithelial and Lamina Propria Lymphocytes in the Murine Small Intestine

1996 • 58 citations

The expression in vivo of a second isoform of pT alpha: implications for the mechanism of pT alpha action.

1998 • 52 citations

The CD3-γδε and CD3-ζ/η Modules Are Each Essential for Allelic Exclusion at the T Cell Receptor β Locus but Are Both Dispensable for the Initiation of V to (D)J Recombination at the T Cell Receptor–β, –γ, and –δ Loci

1998 • 47 citations

Cutting Edge: Recombinase-Activating Gene Expression and V(D)J Recombination in CD4+CD3low Mature T Lymphocytes

2000 • 44 citations

Cutting Edge: The Expression In Vivo of a Second Isoform of pTα: Implications for the Mechanism of pTα Action

1998 • 44 citations

Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development

1997 • 37 citations

Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage

1998 • 34 citations

Expression of Natural Killer Receptor Alleles at Different Ly49 Loci Occurs Independently and Is Regulated by Major Histocompatibility Complex Class I Molecules

2001 • 31 citations

Molecular characterization of gut T cell precursors in euthymic and athymic mice

2001 • 5 citations