Intestinal intraepithelial lymphocytes include precursors committed to the T cell receptor αβ lineage

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Two gut intraepithelial CD8+ lymphocyte populations with different T cell receptors: a role for the gut epithelium in T cell differentiation.

1991 • 599 citations

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

1993 • 528 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Selective Events in T Cell Development

1994 • 486 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop.

1996 • 400 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Abnormal Development of Intestinal Intraepithelial Lymphocytes and Peripheral Natural Killer Cells in Mice Lacking the IL-2 Receptor β Chain

1997 • 359 citations

The V beta repertoire of mouse gut homodimeric alpha CD8+ intraepithelial T cell receptor alpha/beta + lymphocytes reveals a major extrathymic pathway of T cell differentiation.

1991 • 345 citations

Constructing polycompetitor cDNAs for quantitative PCR

1993 • 323 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Generation of Intestinal T Cells from Progenitors Residing in Gut Cryptopatches

1998 • 301 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

1996 • 294 citations

Thymus-independent development and negative selection of T cells expressing T cell receptor alpha/beta in the intestinal epithelium: evidence for distinct circulation patterns of gut- and thymus-derived T lymphocytes.

1992 • 268 citations

Phenotypic complexity of intraepithelial lymphocytes of the small intestine.

1991 • 252 citations

T cell development in mice lacking the CD3-zeta/eta gene.

1993 • 235 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

T Cell Development in Mice that Lack the ζ Chain of the T Cell Antigen Receptor Complex

1993 • 217 citations

Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon.

1993 • 214 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Developmental stage specificity of the lymphoid V(D)J recombination activity.

1987 • 199 citations

Thymus Independent T Cell Development and Selection in the Intestinal Epithelium

1994 • 197 citations

Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine.

1993 • 186 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Developmental and functional impairment of T cells in mice lacking CD3 zeta chains.

1993 • 164 citations

Selection of intraepithelial lymphocytes with CD8 alpha/alpha co-receptors by self-antigen in the murine gut.

1992 • 163 citations

T cell receptor β gene sequences in the circular DNA of thymocyte nuclei: Direct evidence for intramolecular DNA deletion in V-D-J joining

1987 • 144 citations

Extrathymic T cell differentiation

1995 • 129 citations

Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene

1995 • 109 citations

Different expression of the recombination activity gene RAG‐1 in various populations of thymocytes, peripheral T cells and gut thymus‐independent intraepithelial lymphocytes suggests two pathways of T cell receptor rearrangement

1992 • 107 citations

Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.

1993 • 80 citations

CD3⁻CD8⁺ intestinal intraepithelial lymphocytes (IEL) and the extrathymic development of IEL

1994 • 78 citations

Analysis of the intra-epithelial lymphocyte compartment in SCID mice that received co-isogenic CD4+ T cells. Evidence that mature post-thymic CD4+ T cells can be induced to express CD8 alpha in vivo.

1995 • 67 citations

Failure of T cell receptor Vβ negative selection in murine intestinal intra-epithelial lymphocytes

1991 • 55 citations

The CD3-γδε and CD3-ζ/η Modules Are Each Essential for Allelic Exclusion at the T Cell Receptor β Locus but Are Both Dispensable for the Initiation of V to (D)J Recombination at the T Cell Receptor–β, –γ, and –δ Loci

1998 • 47 citations

Anti-IL-4 antibody prevents graft-versus-host disease in mice after bone marrow transplantation. The IgE allotype is an important marker of graft-versus-host disease.

1995 • 47 citations

T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line

1989 • 37 citations

Differential contribution of Lck and Fyn protein tyrosine kinases to intraepithelial lymphocyte development

1997 • 37 citations

_γδ T cells promote CD4 and CD8 expression by SCID thymocytes

1993 • 35 citations

Distinct methylation states of the CD8 beta gene in peripheral T cells and intraepithelial lymphocytes.

1997 • 27 citations

Analysis and expression of a cloned pre-T cell receptor gene. Science. 1994. 266: 1208-1212.

2009 • 26 citations

Selection of peripheral and intestinal T lymphocytes lacking CD3 ζ

1995 • 17 citations

CD16-expressing CD8alpha alpha+ T lymphocytes in the intestinal epithelium: possible precursors of Fc gammaR-CD8alpha alpha+ T cells.

1997 • 17 citations

Phenotypic and functional assessment of intraepithelial lymphocytes bearing a ‘forbidden’ αβ TCR

1994 • 15 citations

T-Cell development and selection in the intestinal epithelium

1995 • 14 citations

TCR repertoire in early fetal mouse thymus

1995 • 3 citations