T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.

1989 • 778 citations

A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

1990 • 611 citations

Junctional sequences of T cell receptor γδ genes: Implications for γδ T cell lineages and for a novel intermediate of V-(D)-J joining

1989 • 572 citations

Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors

1988 • 540 citations

Homing of a γδ thymocyte subset with homogeneous T-cell receptors to mucosal epithelia

1990 • 533 citations

Limited diversity of γδ antigen receptor genes of thy-1+ dendritic epidermal cells

1988 • 522 citations

Developmental regulation of T-cell receptor gene expression

1985 • 522 citations

Transgenesis by means of blastocyst-derived embryonic stem cell lines.

1986 • 432 citations

Lack of N regions in fetal and neonatal mouse immunoglobulin V-D-J junctional sequences.

1990 • 414 citations

Diversity, rearrangement, and expression of murine T cell gamma genes

1986 • 405 citations

Sequence homologies, N sequence insertion and JH gene utilization in VHDJH joining: implications for the joining mechanism and the ontogenetic timing of Ly1 B cell and B-CLL progenitor generation.

1990 • 396 citations

Lymphoid Development in Mice Congenitally Lacking T Cell Receptor αβ-Expressing Cells

1992 • 371 citations

Differential expression of two distinct T-cell receptors during thymocyte development

1987 • 360 citations

The Immunobiology of T Cells with Invariant gammadelta Antigen Receptors

1991 • 343 citations

T-cell receptor δ gene rearrangements in early thymocytes

1987 • 324 citations

The adult T-cell receptor 5-chain is diverse and distinct from that of fetal thymocytes

1988 • 320 citations

Origin of Thy-1+ dendritic epidermal cells of adult mice from fetal thymic precursors

1990 • 306 citations

Teratocarcinomas and Embryonic Stem Cells: A Practical Approach

1988 • 263 citations

Monoclonal antibodies specific to native murine T-cell receptor gamma delta: analysis of gamma delta T cells during thymic ontogeny and in peripheral lymphoid organs.

1989 • 257 citations

The mouse Pgk-1 gene promoter contains an upstream activator sequence

1991 • 200 citations

Different gamma delta T-cell receptors are expressed on thymocytes at different stages of development.

1989 • 183 citations

Production and analysis of chimeric mice

1987 • 175 citations

Predominance of VH-D-JH junctions occurring at sites of short sequence homology results in limited junctional diversity in neonatal antibodies.

1992 • 146 citations

Only d_fl16, d_sp2, and d_q52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which d_fl16 and d_sp2 originate from the same primordial d_h gene

1989 • 137 citations

T-cell receptor gamma delta and gamma transgenic mice suggest a role of a gamma gene silencer in the generation of alpha beta T cells.

1990 • 128 citations

Separate lineages of T cells expressing the αβ and γδ receptors

1989 • 118 citations

T cell receptor-gamma and -delta genes preferentially utilized by adult thymocytes for the surface expression.

1989 • 110 citations

Transgenic mice demonstrate that epithelial homing of gamma/delta T cells is determined by cell lineages independent of T cell receptor specificity.

1990 • 106 citations

Control of γδ T‐Cell Development

1991 • 93 citations

Blockage of αβ T-cell development by TCR γδ transgenes

1989 • 77 citations

Clonal proliferation unlinked to terminal deoxynucleotidyl transferase synthesis in thymocytes of young mice.

1983 • 74 citations

Expression of the T-cell receptor gamma-chain gene products on the surface of peripheral T cells and T-cell blasts generated by allogeneic mixed lymphocyte reaction.

1987 • 63 citations

Predominant variable region gene usage by gamma/delta T cell receptor-bearing cells in the adult thymus.

1988 • 57 citations

Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus.

1992 • 57 citations

Selection of gamma delta T cells with canonical T-cell antigen receptors in fetal thymus.

1990 • 55 citations

Normal recombination substrate VH to DJH rearrangements in pre-B cell lines from scid mice.

1990 • 49 citations

T cell receptor gamma and delta gene junctional sequences in SCID mice: excessive P nucleotide insertion.

1991 • 48 citations

Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression.

1988 • 47 citations

Positive selection of γδ T cells

1990 • 45 citations

T cell function and expression are dramatically altered in T cell receptor Vγ1.1Jγ4Cγ4 transgenic mice

1989 • 44 citations

The genetics of teratocarcinoma transplantation: tumor formation in allogeneic hosts by the embryonal carcinoma cell lines F9 and PCC3

1978 • 38 citations

T-cell receptor delta-chain diversity in peripheral lymphocytes.

1989 • 35 citations

Novel excision products of T cell receptor γ gene rearrangements and developmental stage specificity implied by the frequency of nucleotide insertions at signal joints

1992 • 27 citations

Simultaneous immunoenzyme double labelling using two different enzymes linked directly to monoclonal antibodies or with biotin‐avidin

1986 • 6 citations