Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes

A series of normal stages in the development of the chick embryo

1951 • 12,226 citations

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Retinoic Acid Embryopathy

1985 • 1,921 citations

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1999 • 1,682 citations

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

2002 • 1,442 citations

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 • 1,299 citations

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

1996 • 1,140 citations

Online Mendelian Inheritance In Man (OMIM)

2000 • 1,115 citations

Small molecule modulation of Smoothened activity

2002 • 958 citations

Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

1998 • 839 citations

Sonic hedgehog regulates adult neural progenitor proliferation in vitro and in vivo

2002 • 788 citations

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1996 • 780 citations

Principles for the Buffering of Genetic Variation

2001 • 708 citations

Principles for the Buffering of Genetic Variation

2001 • 686 citations

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 • 664 citations

THE FACE PREDICTS THE BRAIN: DIAGNOSTIC SIGNIFICANCE OF MEDIAN FACIAL ANOMALIES FOR HOLOPROSENCEPHALY (ARHINENCEPHALY)

1964 • 661 citations

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

1998 • 647 citations

Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

1996 • 646 citations

Syndromes of the Head and Neck.

1992 • 613 citations

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

2001 • 609 citations

The world according to bedgebog

1997 • 549 citations

Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired

1998 • 524 citations

Sonic hedgehog Promotes G₁Cyclin Expression and Sustained Cell Cycle Progression in Mammalian Neuronal Precursors

2000 • 480 citations

All Mouse Ventral Spinal Cord Patterning by Hedgehog Is Gli Dependent and Involves an Activator Function of Gli3

2004 • 440 citations

Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly

1999 • 426 citations

Phenotypes of Patients with “Simple” Mendelian Disorders Are Complex Traits: Thresholds, Modifiers, and Systems Dynamics

2000 • 418 citations

Interactions between Hox-negative cephalic neural crest cells and the foregut endoderm in patterning the facial skeleton in the vertebrate head

2002 • 403 citations

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

2000 • 393 citations

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly

1999 • 353 citations

The role of Sonic hedgehog in normal and abnormal craniofacial morphogenesis

1999 • 338 citations

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features

2003 • 336 citations

Multiple Hits during Early Embryonic Development: Digenic Diseases and Holoprosencephaly

2002 • 307 citations

Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death

1999 • 289 citations

The Cellular and Molecular Origins of Beak Morphology

2003 • 275 citations

Genetics of ventral forebrain development and holoprosencephaly

2000 • 264 citations

A zone of frontonasal ectoderm regulates patterning and growth in the face

2003 • 257 citations

Cranial skeletal biology

2003 • 244 citations

Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly

2002 • 243 citations

Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure

2002 • 230 citations

Holoprosencephaly in infants of diabetic mothers

1983 • 220 citations

Teratogenesis of holoprosencephaly

2002 • 195 citations

Hedgehog signal transduction: recent findings

2002 • 183 citations

Sonic Hedgehog Induces Capillary Morphogenesis by Endothelial Cells through Phosphoinositide 3-Kinase

2003 • 167 citations

Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources

1968 • 153 citations

Molecular and Cellular Methods in Developmental Toxicology

2019 • 150 citations

Perspectives on holoprosencephaly: Part II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies.

1992 • 138 citations

Visualization of Gene Expression Patterns by In Situ Hybridization

2019 • 134 citations

Chicken Transcription Factor AP-2: Cloning, Expression and Its Role in Outgrowth of Facial Prominences and Limb Buds

1997 • 127 citations

Roles of FGF receptors in mammalian development and congenital diseases

2003 • 123 citations

Chronologic evaluation of teratogenicity in sheep fed Veratrum californicum.

1965 • 114 citations

Autoregulation ofShhexpression and Shh induction of cell death suggest a mechanism for modulating polarising activity during chick limb development

2000 • 110 citations

Embryonic origin of holoprosencephaly: interrelationship of the developing brain and face.

1982 • 106 citations

Molecular Basis of Environmentally Induced Birth Defects

2002 • 103 citations

Sonic hedgehog signaling at gastrula stages specifies ventral telencephalic cells in the chick embryo

2000 • 96 citations

Holoprosencephaly as a possible embryonic alcohol effect

1991 • 94 citations

Prx1andPrx2are upstream regulators of sonic hedgehog and control cell proliferation during mandibular arch morphogenesis

2001 • 91 citations

Genetic approaches to understanding brain development: Holoprosencephaly as a model

2000 • 80 citations

The interplay of genetic and environmental factors in craniofacial morphogenesis: holoprosencephaly and the role of cholesterol

2003 • 77 citations

Teratogenic Effects of Cyclopamine and Jervine in Rats, Mice and Hamsters

1975 • 75 citations

Teratogenic compounds of Veratrum californicum (Durand)

1971 • 61 citations

Why mutation analysis does not always predict clinical consequences: Explanations in the era of genomics

2002 • 49 citations

Cyclopamine-Induced Holoprosencephaly and Associated Craniofacial Malformations in the Golden Hamster: Anatomic and Molecular Events

1998 • 36 citations

Carbon-13 and Proton Nuclear Magnetic Resonance Spectra of Veratrum Alkaloids

1986 • 31 citations

Effects of alkaloids of Veratrum californicum on chick embryos

1973 • 30 citations

Expression of Veratrum alkaloid teratogenicity in the mouse

1990 • 29 citations

Perspectives on holoprosencephaly: Part II. Central nervous system, craniofacial anatomy, syndrome commentary, diagnostic approach, and experimental studies.

1992 • 23 citations

Teratogenic Compounds of Veratrum californicum (Durand). XIV. Limb Deformities Produced by Cyclopamine

1973 • 20 citations

The molecular genetics of holoprosencephaly: a model of brain development for the next century

1999 • 18 citations

A looking glass perspective: thalidomide and cyclopamine.

1999 • 16 citations

Proceedings: Effects of alkaloids of Veratrum californicum on developing embryos.

1973 • 4 citations