Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

1996 • 3,041 citations

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 • 2,021 citations

Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome

1996 • 1,850 citations

Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

1997 • 1,695 citations

The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary.

1996 • 1,208 citations

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

1996 • 1,140 citations

Nomenclature for the description of human sequence variations

2001 • 914 citations

Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 • 889 citations

Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum

1999 • 857 citations

Biochemical evidence that Patched is the Hedgehog receptor

1996 • 852 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog

1997 • 712 citations

Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

1997 • 633 citations

Smoothened Mutants Reveal Redundant Roles for Shh and Ihh Signaling Including Regulation of L/R Asymmetry by the Mouse Node

2001 • 599 citations

Basal cell carcinomas in mice overexpressing Gli2 in skin

2000 • 396 citations

The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants

1998 • 371 citations

A Hedgehog-Insensitive Form of Patched Provides Evidence for Direct Long-Range Morphogen Activity of Sonic Hedgehog in the Neural Tube

2001 • 364 citations

The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly

1999 • 353 citations

Holoprosencephaly in human embryos: Epidemiologic studies of 150 cases

1977 • 320 citations

Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors.

1997 • 315 citations

Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog

1997 • 277 citations

Holoprosencephaly: Epidemiologic and clinical characteristics of a California population

1996 • 195 citations

Mutations in the C-Terminal Domain of Sonic Hedgehog Cause Holoprosencephaly

1997 • 169 citations

Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly

1999 • 149 citations

Overexpression of ptc1 Inhibits Induction of Shh Target Genes and Prevents Normal Patterning in the Neural Tube

1999 • 77 citations

The Hedgehog signalling pathway and cancer

2001 • 42 citations