Shedding of lymphocyte function–associated antigen-1 (LFA-1) in a human inflammatory response

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

1987 • 1,712 citations

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

2003 • 1,168 citations

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

1989 • 1,135 citations

Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro.

1989 • 1,115 citations

Bidirectional Transmembrane Signaling by Cytoplasmic Domain Separation in Integrins

2003 • 784 citations

RhoA is required for monocyte tail retraction during transendothelial migration

2001 • 498 citations

Hemoglobin Scavenger Receptor CD163 Mediates Interleukin-10 Release and Heme Oxygenase-1 Synthesis

2003 • 451 citations

Lymphocyte arrest requires instantaneous induction of an extended LFA-1 conformation mediated by endothelium-bound chemokines

2005 • 405 citations

Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders

1991 • 387 citations

Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis

2004 • 377 citations

The Major Histocompatibility Complex-Restricted Antigen Receptor on T Cells

1984 • 368 citations

Neutrophil apoptosis is associated with a reduction in CD16 (Fc gamma RIII) expression.

1994 • 333 citations

Lymphocyte Migration in Lymphocyte Function-associated Antigen (LFA)-1–deficient Mice

1999 • 329 citations

Basophils in bronchial asthma with reference to reagin‐type allergy

1973 • 237 citations

Coordinated Redistribution of Leukocyte LFA-1 and Endothelial Cell ICAM-1 Accompany Neutrophil Transmigration

2004 • 236 citations

LFA-1-induced T cell migration on ICAM-1 involves regulation of MLCK-mediated attachment and ROCK-dependent detachment

2003 • 236 citations

PECAM-1 (CD31) Homophilic Interaction Up-Regulates α6β1 on Transmigrated Neutrophils In Vivo and Plays a Functional Role in the Ability of α6 Integrins to Mediate Leukocyte Migration through the Perivascular Basement Membrane

2002 • 224 citations

Ca2+-dependent myosin II activation is required for uropod retraction during neutrophil migration

2000 • 222 citations

Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction

2004 • 196 citations

Mechanisms contributing to the activity of integrins on leukocytes

2002 • 181 citations

A novel β ₁ ‐dependent adhesion pathway on neutrophils: a mechanism invoked by dihydrocytochalasin B or endothelial transmigration

1995 • 180 citations

The Use of Lymphocyte Function–Associated Antigen (Lfa)-1–Deficient Mice to Determine the Role of Lfa-1, Mac-1, and α4 Integrin in the Inflammatory Response of Neutrophils

2001 • 180 citations

Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation

2001 • 161 citations

Leukocyte Migration Is Regulated by L-Selectin Endoproteolytic Release

2003 • 154 citations

I domain of beta 2 integrin lymphocyte function-associated antigen-1 contains a binding site for ligand intercellular adhesion molecule-1.

1994 • 151 citations

Functional α4-integrin: A newly identified pathway of neutrophil recruitment in critically ill septic patients

2001 • 142 citations

Rat blood neutrophils express very late antigen 4 and it mediates migration to arthritic joint and dermal inflammation.

1996 • 141 citations

L-Selectin Shedding Does Not Regulate Constitutive T Cell Trafficking but Controls the Migration Pathways of Antigen-activated T Lymphocytes

2003 • 133 citations

Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other

2003 • 131 citations

Macrophage release of transforming growth factor β1 during resolution of monosodium urate monohydrate crystal–induced inflammation

2004 • 126 citations

Importance of integrin LFA-1 deactivation for the generation of immune responses

2005 • 119 citations

Integrin α2β1 (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue

2000 • 119 citations

Specification of the Direction of Adhesive Signaling by the Integrin β Cytoplasmic Domain

2005 • 105 citations

Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3.

1994 • 102 citations

Structural and Functional Studies with Antibodies to the Integrin β2 Subunit

2000 • 96 citations

PECAM-1, α6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration

2005 • 95 citations

Regulation of CD18 expression on neutrophils in response to fluid shear stress

2003 • 92 citations

Folding of the β-propeller domain of the integrin α_Lsubunit is independent of the I domain and dependent on the β₂ subunit

1997 • 73 citations

Cantharidin blisters: a technique for investigating leukocyte trafficking and cytokine production at sites of inflammation in humans

2001 • 70 citations

Amino Acid Sequences within the α Subunit of Integrin α_Mβ₂(Mac-1) Critical for Specific Recognition of C3bi

1999 • 69 citations

Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin β subunits

2001 • 63 citations

The Role of the CPNKEKEC Sequence in the β2 Subunit I Domain in Regulation of Integrin αLβ2 (LFA-1)

2002 • 55 citations

Polar Redistribution of the Sialoglycoprotein CD43: Implications for T Cell Function

2002 • 52 citations

Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen 1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a

1995 • 51 citations

The major histocompatibility complex-restricted antigen receptor on T cells. IX. Role of accessory molecules in recognition of antigen plus isolated IA.

1986 • 50 citations

Biosynthesis and glycosylation of p150,95 and related leukocyte adhesion proteins.

1987 • 41 citations

LFA-1 (CD11a/CD18) triggers hydrogen peroxide production by canine neutrophils

2000 • 30 citations

Ligation of lymphocyte function-associated antigen-1 on monocytes decreases very late antigen-4-mediated adhesion through a reactive oxygen species-dependent pathway

2004 • 29 citations

Evidence that TNF-induced respiratory burst of adherent PMN is mediated by integrin alpha(L)beta(2).

2002 • 23 citations

Evidence that TNF-induced respiratory burst of adherent PMN is mediated by integrin αLβ2

2002 • 17 citations