Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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Identification and characterization of a new member of the TNF family that induces apoptosis

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Inhibition of death receptor signals by cellular FLIP

1997 • 2,577 citations

IAP family proteins---suppressors of apoptosis

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FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Safety and antitumor activity of recombinant soluble Apo2 ligand

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Histone deacetylases and cancer: causes and therapies

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Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

1996 • 1,793 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

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An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

2002 • 1,325 citations

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

1997 • 1,305 citations

FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)

1997 • 1,207 citations

Conversion of Bcl-2 to a Bax-like Death Effector by Caspases

1997 • 1,116 citations

Caspase Cleaved BID Targets Mitochondria and Is Required for Cytochrome c Release, while BCL-XL Prevents This Release but Not Tumor Necrosis Factor-R1/Fas Death

1999 • 1,024 citations

The inhibitors of apoptosis (IAPs) and their emerging role in cancer

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Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Distinct Caspase Cascades Are Initiated in Receptor-mediated and Chemical-induced Apoptosis

1999 • 829 citations

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB

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Histone deacetylases, transcriptional control, and cancer

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Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

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Butyrate production from dietary fibre and protection against large bowel cancer in a rat model.

1993 • 555 citations

FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis

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The Human Histone Deacetylase Family

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Histone deacetylase inhibitors as new cancer drugs

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The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin

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The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species

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Regulation of cell proliferation by the E2F transcription factors

1998 • 486 citations

Caspase-3-dependent Cleavage of Bcl-2 Promotes Release of Cytochrome c

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Cleavage of p21Cip1/Waf1 and p27Kip1 Mediates Apoptosis in Endothelial Cells through Activation of Cdk2: Role of a Caspase Cascade

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The retinoblastoma gene family in differentiation and development

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Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo.

2000 • 391 citations

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

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Inhibition of TRAIL-induced apoptosis by Bcl-2 overexpression

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Resistance to Fas-mediated apoptosis: activation of Caspase 3 is regulated by cell cycle regulator p21WAF1 and IAP gene family ILP

1998 • 355 citations

Histone acetylation and disease

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Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

2001 • 326 citations

Histone deacetylase inhibitors in cancer treatment

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Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

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Enforced expression of the c-myc oncogene inhibits cell differentiation by precluding entry into a distinct predifferentiation state in G0/G1.

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Histone Acetylation and Chromatin Remodeling

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Increased Expression of Death Receptors 4 and 5 Synergizes the Apoptosis Response to Combined Treatment with Etoposide and TRAIL

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Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Apicidin, a Histone Deacetylase Inhibitor, Induces Apoptosis and Fas/Fas Ligand Expression in Human Acute Promyelocytic Leukemia Cells

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Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression.

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The kiss of death: promises and failures of death receptors and ligands in cancer therapy

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Antileukemic drugs increase death receptor 5 levels and enhance Apo-2L–induced apoptosis of human acute leukemia cells

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Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease

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Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

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Synergistic Induction of Apoptosis by the Combination of TRAIL and Chemotherapy in Chemoresistant Ovarian Cancer Cells

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Caspase 3-mediated Cleavage of p21 Associated with the Cyclin A-Cyclin-dependent Kinase 2 Complex Is a Prerequisite for Apoptosis in SK-HEP-1 Cells

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Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA)

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Positive and negative regulation of apoptotic pathways by cytotoxic agents in hematological malignancies

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Induction of Apoptosis and Potentiation of Ceramide-mediated Cytotoxicity by Sphingoid Bases in Human Myeloid Leukemia Cells

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Up-regulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity.

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Histone deacetylases as therapeutic targets in hematologic malignancies

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Raf-1 and Bcl-2 induce distinct and common pathways that contribute to breast cancer drug resistance.

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Failure of Bcl‐2 to block cytochrome c redistribution during TRAIL‐induced apoptosis

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Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals.

1998 • 101 citations

X-linked inhibitor of apoptosis (XIAP) blocks Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of prostate cancer cells in the presence of mitochondrial activation: sensitization by overexpression of second mitochondria-derived activator of caspase/direct IAP-binding protein with low pl (Smac/DIABLO).

2002 • 98 citations

p21WAF1/CIP1 Inhibits Initiator Caspase Cleavage by TRAIL Death Receptor DR4

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Enhanced Sensitivity of G1 Arrested Human Cancer Cells Suggests a Novel Therapeutic Strategy Using a Combination of Simvastatin and TRAIL

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Evidence of a functional role for the cyclin-dependent kinase-inhibitor p21WAF1/CIP1/MDA6 in promoting differentiation and preventing mitochondrial dysfunction and apoptosis induced by sodium butyrate in human myelomonocytic leukemia cells (U937)

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Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma.

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Butyrate sensitizes human colon cancer cells to TRAIL-mediated apoptosis

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The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.

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Bcl-2 and apoptosis in chronic lymphocytic leukemia

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Intracellular Mechanisms of TRAIL and Its Role in Cancer Therapy

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APOPTOSIS-INDUCED BY TRAIL AND TNF-α IN HUMAN MULTIPLE MYELOMA CELLS IS NOT BLOCKED BY BCL-2

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Immunobiology of Tumor Necrosis Factor Receptor Superfamily

2002 • 59 citations

Pioglitazone Inhibits Growth of Carcinoid Cells and Promotes TRAIL-Induced Apoptosis by Induction of p21<sup>waf1/cip1</sup>

2001 • 59 citations

Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis

2002 • 54 citations

Dysregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/MDA6 increases the susceptibility of human leukemia cells (U937) to 1-beta-D-arabinofuranosylcytosine-mediated mitochondrial dysfunction and apoptosis.

1999 • 52 citations

Enhanced tumor killing by Apo2L/TRAIL and CPT-11 co-treatment is associated with p21 cleavage and differential regulation of Apo2L/TRAIL ligand and its receptors

2002 • 50 citations

Failure of Bcl-2 to block mitochondrial dysfunction during TRAIL-induced apoptosis. Tumor necrosis-related apoptosis-inducing ligand.

2001 • 48 citations

The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.

2001 • 47 citations

Ubiquitin/Proteasome-dependent Degradation of D-type Cyclins Is Linked to Tumor Necrosis Factor-induced Cell Cycle Arrest

2002 • 45 citations

Synergistic Induction of Apoptosis in Human Myeloid Leukemia Cells by Phorbol 12-Myristate 13-Acetate and Flavopiridol Proceeds via Activation of Both the Intrinsic and Tumor Necrosis Factor-Mediated Extrinsic Cell Death Pathways

2002 • 44 citations

Sodium Butyrate Induces G2 Arrest in the Human Breast Cancer Cells MDA-MB-231 and Renders Them Competent for DNA Rereplication

1999 • 44 citations

Potentiation of 1-β-d-arabinofuranosylcytosine-mediated mitochondrial damage and apoptosis in human leukemia cells (U937) overexpressing Bcl-2 by the kinase inhibitor 7-hydroxystaurosporine (UCN-01)

2000 • 39 citations

Sodium butyrate induces apoptosis in human renal cell carcinoma cells and synergistically enhances their sensitivity to anti-Fas-mediated cytotoxicity.

2000 • 34 citations

Bryostatin 1 and UCN-01 Potentiate 1-β-d-Arabinofuranosylcytosine-Induced Apoptosis in Human Myeloid Leukemia Cells through Disparate Mechanisms

2003 • 25 citations

Modulation of the activity of Bcl-2 in Waldenstrom's macroglobulinemia using antisense oligonucleotides

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Chemosensitization of T-47D breast carcinoma cells to TRAIL and Fas receptor-induced killing.

2002 • 15 citations

Aberrant bcl-2 and bax protein expression related to chemotherapy response in neuroblastoma.

2003 • 11 citations