Histone deacetylases and cancer: causes and therapies

The language of covalent histone modifications

2000 • 8,260 citations

Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A.

1990 • 1,835 citations

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

1999 • 1,774 citations

Histone Acetyltransferases

2001 • 1,745 citations

Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

2001 • 1,684 citations

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

1999 • 1,640 citations

Hemoglobin Synthesis in Murine Virus-Induced Leukemic Cells In Vitro: Stimulation of Erythroid Differentiation by Dimethyl Sulfoxide

1971 • 1,371 citations

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

2000 • 1,360 citations

Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells

2000 • 1,158 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

1995 • 1,114 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

2000 • 946 citations

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

2000 • 938 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB–binding protein

1996 • 756 citations

Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes

2001 • 729 citations

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

2000 • 720 citations

Trichostatin A and trapoxin: Novel chemical probes for the role of histone acetylation in chromatin structure and function

1995 • 719 citations

Erythroleukemic Differentiation

1978 • 694 citations

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1999 • 686 citations

The expression of a small fraction of cellular genes is changed in response to histone hyperacetylation.

1996 • 662 citations

Histone deacetylases, transcriptional control, and cancer

2000 • 622 citations

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

2000 • 608 citations

Mutations truncating the EP300 acetylase in human cancers

2000 • 590 citations

The Human Histone Deacetylase Family

2001 • 541 citations

Regulation of Skeletal Myogenesis by Association of the MEF2 Transcription Factor with Class II Histone Deacetylases

2000 • 537 citations

Histone deacetylase inhibitors as new cancer drugs

2001 • 533 citations

ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex

1998 • 525 citations

Therapeutic Targeting of Transcription in Acute Promyelocytic Leukemia by Use of an Inhibitor of Histone Deacetylase

1998 • 517 citations

Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase.

1993 • 510 citations

FR901228, a Potent Antitumor Antibiotic, Is a Novel Histone Deacetylase Inhibitor

1998 • 481 citations

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

1996 • 421 citations

Genomewide studies of histone deacetylase function in yeast

2000 • 415 citations

Conjunction dysfunction: CBP/p300 in human disease

1998 • 406 citations

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

2000 • 400 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

A new group of potent inducers of differentiation in murine erythroleukemia cells.

1976 • 379 citations

Functional significance of histone deacetylase diversity

2001 • 351 citations

Histone acetylation and disease

2001 • 331 citations

Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives

1999 • 286 citations

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1999 • 282 citations

Histone Acetylation and Chromatin Remodeling

2001 • 264 citations

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

1999 • 235 citations

Cloning and characterization of a histone deacetylase, HDAC9

2001 • 234 citations

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression

1998 • 229 citations

All Patients With the T(11; 16)(q23; p13.3) That Involves MLL and CBP Have Treatment-Related Hematologic Disorders

1997 • 219 citations

Histone Acetylation at Promoters Is Differentially Affected by Specific Activators and Repressors

2001 • 207 citations

A phase I dose escalation and bioavailability study of oral sodium phenylbutyrate in patients with refractory solid tumor malignancies.

2001 • 201 citations

Covalent modifications of histones: expression from chromatin templates

1998 • 198 citations

Inhibitors of histone deacetylase relieve ETO-mediated repression and induce differentiation of AML1-ETO leukemia cells.

1999 • 195 citations

Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase

1998 • 192 citations

A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.

2000 • 192 citations

Isolation and Characterization of Mammalian HDAC10, a Novel Histone Deacetylase

2002 • 189 citations

Histone Acetylation Modifiers in the Pathogenesis of Malignant Disease

2000 • 180 citations

Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome

2001 • 162 citations

Suberoylanilide Hydroxamic Acid as a Potential Therapeutic Agent for Human Breast Cancer Treatment

2000 • 157 citations

The histone deacetylase inhibitor, CBHA, inhibits growth of human neuroblastoma xenografts in vivo, alone and synergistically with all-trans retinoic acid.

2001 • 155 citations

Transcription therapy for cancer

2001 • 147 citations

Telomerase activation by histone deacetylase inhibitor in normal cells

2001 • 146 citations

Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity.

2001 • 144 citations

Chronic Oral Administration of CI-994: A Phase I Study

2001 • 136 citations

Acute Mixed Lineage Leukemia With an inv(8)(p11q13) Resulting in Fusion of the Genes for MOZ and TIF2

1998 • 134 citations

Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells

1999 • 132 citations

Butyrate as a differentiating agent: pharmacokinetics, analogues and current status

1994 • 130 citations

Histone deacetylase 4 associates with extracellular signal-regulated kinases 1 and 2, and its cellular localization is regulated by oncogenic Ras

2000 • 120 citations

Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase.

2001 • 119 citations

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

1999 • 114 citations

Chemoprevention of carcinogen-induced mammary tumorigenesis by the hybrid polar cytodifferentiation agent, suberanilohydroxamic acid (SAHA).

2000 • 113 citations

Modifying histones to tame cancer: clinical development of sodium phenylbutyrate and other histone deacetylase inhibitors

2000 • 108 citations

Epigenetic Regulation of Gelsolin Expression in Human Breast Cancer Cells

1999 • 107 citations

Histone Deacetylase: A Target for Antiproliferative and Antiprotozoal Agents

2001 • 106 citations

Analogues of trichosтatin a and trapoxin B as histone deacetylase inhibitors

1997 • 85 citations

Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity

1999 • 83 citations

The synthesis of cyclic tetrapeptoid analogues of the antiprotozoal natural product apicidin

2001 • 76 citations

HDAC1, a Histone Deacetylase, Forms a Complex with Hus1 and Rad9, Two G2/M Checkpoint Rad Proteins

2000 • 75 citations

Histone Hyperacetylation Induced by Histone Deacetylase Inhibitors Is Not Sufficient to Cause Growth Inhibition in Human Dermal Fibroblasts

2001 • 68 citations

Design and synthesis of a novel class of histone deacetylase inhibitors

2001 • 68 citations

Role of histone deacetylases in acute leukemia

1998 • 65 citations

Structural modifications of histones and their possible role in the regulation of ribonucleic acid synthesis.

1966 • 55 citations

Synthesis of Apicidin-Derived Quinolone Derivatives: Parasite-Selective Histone Deacetylase Inhibitors and Antiproliferative Agents

2000 • 49 citations

In vivo Effects of a Histone Deacetylase Inhibitor, FK228, on Human Acute Promyelocytic Leukemia in NOD/Shi‐scid/scid Mice

2001 • 45 citations

Association of Histone Deacetylase with COUP-TF in Tumorigenic Ad12-Transformed Cells and Its Potential Role in Shut-Off of MHC Class I Transcription

2000 • 45 citations

Loss of heterozygosity on chromosome 16 in hepatocellular carcinoma

1992 • 44 citations

Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells

1997 • 39 citations

Chromatin organisation and human disease

2000 • 25 citations