Up-regulation of p21(WAF1/CIP1) by histone deacetylase inhibitors reduces their cytotoxicity.

Histone acetylation in chromatin structure and transcription

1997 • 2,834 citations

Intracellular ATP levels determine cell death fate by apoptosis or necrosis.

1997 • 1,218 citations

p21 is necessary for the p53-mediated G1 arrest in human cancer cells.

1995 • 1,193 citations

Histone deacetylase inhibitor selectively induces p21 ^WAF1 expression and gene-associated histone acetylation

2000 • 1,091 citations

Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases

1999 • 957 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

1999 • 686 citations

Apoptosis inhibitory activity of cytoplasmic p21Cip1/WAF1 in monocytic differentiation

1999 • 587 citations

A novel assay to measure loss of plasma membrane asymmetry during apoptosis of adherent cells in culture

1996 • 534 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

Effects of p21^{Waf1/Cip1/Sdi1}on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases

2000 • 426 citations

Histone Deacetylase Inhibition Selectively Alters the Activity and Expression of Cell Cycle Proteins Leading to Specific Chromatin Acetylation and Antiproliferative Effects

1999 • 394 citations

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

1997 • 376 citations

Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

1999 • 282 citations

Histone Deacetylase Inhibitors Trigger a G2 Checkpoint in Normal Cells That Is Defective in Tumor Cells

2000 • 251 citations

Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase

1999 • 235 citations

Failure of Poly(ADP-Ribose) Polymerase Cleavage by Caspases Leads to Induction of Necrosis and Enhanced Apoptosis

1999 • 228 citations

Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma.

1999 • 182 citations

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

1997 • 160 citations

Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21

1999 • 157 citations

Histone deacetylase inhibitors as potential anti-skin cancer agents.

1999 • 140 citations

Mitochondrial Regulation of Cell Death: Mitochondria Are Essential for Procaspase 3-p21 Complex Formation To Resist Fas-Mediated Cell Death

1999 • 133 citations

Apoptosis induced by the histone deacetylase inhibitor sodium butyrate in human leukemic lymphoblasts

1999 • 132 citations

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate

1999 • 114 citations

p21WAF1/CIP1 Inhibits Initiator Caspase Cleavage by TRAIL Death Receptor DR4

2000 • 97 citations

Chapter 3 Cell Cycle Phase-Specific Analysis of Cell Viability Using Hoechst 33342 and Propidium Iodide after Ethanol Preservation

1990 • 56 citations

Tumor selectivity and transcriptional activation by azelaic bishydroxamic acid in human melanocytic cells

1997 • 39 citations