APOPTOSIS-INDUCED BY TRAIL AND TNF-α IN HUMAN MULTIPLE MYELOMA CELLS IS NOT BLOCKED BY BCL-2

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Apoptosis by Death Factor

1997 • 5,038 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Identification and characterization of a new member of the TNF family that induces apoptosis

1995 • 2,890 citations

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

1993 • 2,546 citations

Control of TRAIL-Induced Apoptosis by a Family of Signaling and Decoy Receptors

1997 • 1,694 citations

An Antagonist Decoy Receptor and a Death Domain-Containing Receptor for TRAIL

1997 • 1,506 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 1,078 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line

1993 • 898 citations

Bcl-2 initiates a new category of oncogenes: regulators of cell death

1992 • 860 citations

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

1997 • 797 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

A novel receptor for Apo2L/TRAIL contains a truncated death domain

1997 • 650 citations

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

1997 • 566 citations

Effect of bcl-2 on Fas antigen-mediated cell death.

1993 • 442 citations

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

1998 • 382 citations

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

1997 • 372 citations

A Novel Family of Viral Death Effector Domain-containing Molecules That Inhibit Both CD-95- and Tumor Necrosis Factor Receptor-1-induced Apoptosis

1997 • 343 citations

Differential expression of bcl-2 and susceptibility to anti-Fas- mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils

1994 • 320 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Protooncogene bcl-2 gene transfer abrogates Fas/APO-1 antibody-mediated apoptosis of human malignant glioma cells and confers resistance to chemotherapeutic drugs and therapeutic irradiation.

1995 • 258 citations

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

1996 • 251 citations

A bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection.

1996 • 182 citations

Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism

1997 • 174 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines

1994 • 153 citations

The role of interleukin‐1 and tumour necrosis factor‐α in human multiple myeloma

1990 • 151 citations

Purified CD34+ Lin- Thy+ stem cells do not contain clonal myeloma cells

1995 • 146 citations

High levels of p26BCL-2 oncoprotein retard taxol-induced apoptosis in human pre-B leukemia cells.

1994 • 128 citations

THE ENZYMATIC SYNTHESIS OF PEPTIDE BONDS

1938 • 110 citations

Portrait of an executioner: the molecular mechanism of Fas/APO-1-induced apoptosis

1997 • 100 citations

The Cloning and Expression of a New Guanylyl Cyclase Orphan Receptor

1998 • 93 citations

Bcl-2 overexpression is associated with resistance to paclitaxel, but not gemcitabine, in multiple myeloma cells.

1998 • 81 citations

Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program.

1995 • 72 citations

Apoptosis Mediated by the Fas System

1996 • 72 citations

Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas.

1994 • 69 citations

Bcl-2 overexpression is associated with resistance to dexamethasone, but not melphalan, in multiple myeloma cells.

1998 • 60 citations

Expression of the Fas antigen on primary human leukemia cells

1995 • 45 citations

Evolutionary Conservation of Function Among Mammalian, Avian, and Viral Homologs of the Bcl-2 Oncoprotein

1994 • 43 citations

Fluctuations and ultrastructural localization of oncoproteins and cell cycle regulatory proteins during growth and apoptosis of synchronized AGF cells.

1994 • 42 citations

Tumor Necrosis Factor-α and Interleukin 4 in Myeloma Cell Precursor Differentiation

1996 • 23 citations

The role of p53, bcl-2 and bax network in dexamethasone induced apoptosis in multiple myeloma cell lines

1996 • 15 citations

bcl-2 plays a major role in resistance to dexamethasone induced apoptosis in multiple myeloma cell lines

1996 • 12 citations

bcl-2 plays a critical role in growth and in spontaneous or induced apoptosis in myeloma cell lines

1996 • 11 citations

Fas (APO-1/CD95)-mediated apoptosis is independent of bcl-2: a study with cell lines overexpressing bcl-2 and with bcl-2 transfected cell lines.

1998 • 4 citations