Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture

1977 • 2,134 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases

1998 • 899 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest

1994 • 625 citations

p21 ^WAF1 is required for butyrate-mediated growth inhibition of human colon cancer cells

1998 • 530 citations

Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation

1996 • 494 citations

Second generation hybrid polar compounds are potent inducers of transformed cell differentiation.

1996 • 421 citations

HL-60 cells induced to differentiate towards neutrophils subsequently die via apoptosis

1990 • 390 citations

Induction of caspase-3 protease activity and apoptosis by butyrate and trichostatin A (inhibitors of histone deacetylase): dependence on protein synthesis and synergy with a mitochondrial/cytochrome c-dependent pathway.

1997 • 376 citations

Human Fibroblast Commitment to a Senescence-Like State in Response to Histone Deacetylase Inhibitors Is Cell Cycle Dependent

1996 • 265 citations

Cleavage of CDK Inhibitor p21Cip1/Waf1 by Caspases Is an Early Event during DNA Damage-induced Apoptosis

1998 • 215 citations

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

1992 • 197 citations

Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation.

1995 • 197 citations

Apoptotic death in adenocarcinoma cell lines induced by butyrate and other histone deacetylase inhibitors

1997 • 160 citations

Bcl2 inhibits apoptosis associated with terminal differentiation of HL- 60 myeloid leukemia cells

1994 • 136 citations

A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate–induced invasion in mouse keratinocytes

1997 • 113 citations

Neuronal apoptosis induced by histone deacetylase inhibitors

1998 • 110 citations

Activation of Raf-1 and mitogen-activated protein kinases during monocytic differentiation of human myeloid leukemia cells.

1994 • 106 citations

Butyrate-induced G1 arrest results from p21-independent disruption of retinoblastoma protein-mediated signals.

1998 • 101 citations

Differential Expression of Human Histone Deacetylase mRNAs in Response to Immune Cell Apoptosis Induction by Trichostatin A and Butyrate

1998 • 99 citations

Agents that Down-Regulate or Inhibit Protein Kinase C Circumvent Resistance to 1-β-D-Arabinofuranosylcytosine-Induced Apoptosis in Human Leukemia Cells that Overexpress Bcl-2

1997 • 78 citations

Constitutive Expression of the Cyclin-dependent Kinase Inhibitor p21 Is Transcriptionally Regulated by the Tumor Suppressor Protein p53

1998 • 69 citations

Divergent effects of bryostatin 1 and phorbol myristate acetate on cell cycle arrest and maturation in human myelomonocytic leukemia cells (U937)

1998 • 61 citations

Evidence of a Functional Role for the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1/MDA6in the Reciprocal Regulation of PKC Activator-Induced Apoptosis and Differentation in Human Myelomonocytic Leukemia Cells

1998 • 54 citations

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

1992 • 37 citations

Expression of the p53 tumor suppressor gene induces differentiation and promotes induction of differentiation by 1,25-dihydroxycholecalciferol in leukemic U-937 cells

1996 • 36 citations

Modulation of Protein Kinase C Activity and Calcium-Sensitive Isoform Expression in Human Myeloid Leukemia Cells by Bryostatin 1: Relationship to Differentiation and Ara-C-Induced Apoptosis

1996 • 29 citations

Hexamethylene bisacetamide in myelodysplastic syndrome and acute myelogenous leukemia: a phase II clinical trial with a differentiation- inducing agent

1992 • 10 citations

Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells

1994 • 5 citations