Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads

1994 • 726 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase

1992 • 709 citations

Mitogen activated protein (MAP) kinase transforms tau protein into an Alzheimer-like state.

1992 • 563 citations

Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau

1994 • 561 citations

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205

1995 • 551 citations

Proline-directed and Non-proline-directed Phosphorylation of PHF-tau

1995 • 549 citations

Glycogen synthase kinase‐3 and the Alzheimer‐like state of microtubule‐associated protein tau

1992 • 507 citations

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region.

1992 • 468 citations

Protein sequence and mass spectrometric analyses of tau in the Alzheimer's disease brain.

1992 • 415 citations

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease: identification of phosphorylation sites in tau protein

1994 • 349 citations

Detection of Phosphorylated Ser262 in Fetal Tau, Adult Tau, and Paired Helical Filament Tau

1995 • 345 citations

A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle.

1995 • 305 citations

Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

1993 • 289 citations

p42 map kinase phosphorylation sites in microtubule‐associated protein tau are dephosphorylated by protein phosphatase 2A₁ Implications for Alzheimer's disease

1992 • 273 citations

A cdc2‐related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline‐directed protein kinase associated with microtubule

1993 • 235 citations

In vivo phosphorylation sites in fetal and adult rat tau.

1993 • 233 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Hyperphosphorylation of Tau in PHF

1995 • 220 citations

Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1992 • 217 citations

Protein Phosphatase 2A Is the Major Enzyme in Brain that Dephosphorylates τ Protein Phosphorylated by Proline‐Directed Protein Kinases or Cyclic AMP‐Dependent Protein Kinase

1995 • 161 citations

Characterization of Two Distinct Monoclonal Antibodies to Paired Helical Filaments: Further Evidence for Fetal‐Type Phosphorylation of the τ in Paired Helical Filaments

1993 • 104 citations

Reconstitution of Neuronal Cdc2-like Kinase from Bacteria-expressed Cdk5 and an Active Fragment of the Brain-specific Activator

1995 • 96 citations

Differential effect of phosphorylation and substrate modulation on tau's ability to promote microtubule growth and nucleation.

1994 • 85 citations

Disruption of the cytoskeleton in Alzheimer's disease

1995 • 77 citations

Phosphorylation of tau protein by purified p34cdc28 and a related protein kinase from neurofilaments.

1992 • 66 citations

Protein Kinase F_A/Glycogen Synthase Kinase‐3α After Heparin Potentiation Phosphorylates τ on Sites Abnormally Phosphorylated in Alzheimer's Disease Brain

1994 • 55 citations