Effects of frontotemporal dementia FTDP‐17 mutations on heparin‐induced assembly of tau filaments

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain.

1989 • 989 citations

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans

1996 • 974 citations

Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17

1998 • 954 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

1977 • 834 citations

Tau protein and the neurofibrillary pathology of Alzheimer's disease

1993 • 710 citations

Tau protein pathology in neurodegenerative diseases

1998 • 674 citations

Domains of tau Protein and Interactions with Microtubules

1994 • 630 citations

Structure and novel exons of the human .tau. gene

1992 • 587 citations

Structural characterization of the core of the paired helical filament of Alzheimer disease.

1988 • 566 citations

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.

1994 • 544 citations

Tau proteins with FTDP‐17 mutations have a reduced ability to promote microtubule assembly

1998 • 469 citations

Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17

1998 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Tau interacts with src-family non-receptor tyrosine kinases

1998 • 441 citations

High Prevalence of Mutations in the Microtubule-Associated Protein Tau in a Population Study of Frontotemporal Dementia in the Netherlands

1999 • 419 citations

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

1999 • 418 citations

Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders.

1998 • 403 citations

Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau

1994 • 391 citations

Regulation of the Phosphorylation State and Microtubule-Binding Activity of Tau by Protein Phosphatase 2A

1996 • 389 citations

Polymerization of τ into Filaments in the Presence of Heparin: The Minimal Sequence Required for τ ‐ τ Interaction

1996 • 387 citations

Localization of disinhibition-dementia-parkinsonism-amyotrophy complex to 17q21-22.

1994 • 342 citations

Tau Mutations Cause Frontotemporal Dementias

1998 • 267 citations

Segregation of a Missense Mutation in the Microtubule-Associated Protein Tau Gene with Familial Frontotemporal Dementia and Parkinsonism

1998 • 236 citations

τ in Paired Helical Filaments Is Functionally Distinct from Fetal τ: Assembly Incompetence of Paired Helical Filament‐τ

1993 • 228 citations

Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation

1999 • 207 citations

FTDP‐17 mutations N279K and S305N in tau produce increased splicing of exon 10

1999 • 203 citations

Alzheimer-like Changes in Microtubule-associated Protein Tau Induced by Sulfated Glycosaminoglycans

1997 • 199 citations

Tau gene mutation in familial progressive subcortical gliosis

1999 • 189 citations

Tau Pathology in a Family with Dementia and a P301L Mutation in Tau

1999 • 181 citations

Hereditary frontotemporal dementia is linked to chromosome 17q21—q22: A genetic and clinicopathological study of three dutch families

1997 • 175 citations

A distinct familial presenile dementia with a novel missense mutation in the tau gene

1999 • 156 citations

Protein Phosphatase 1 Is Targeted to Microtubules by the Microtubule-associated Protein Tau

1998 • 144 citations

Identification of 3- and 4-repeat tau isoforms within the PHF in Alzheimer's disease.

1991 • 143 citations

The Neuropathology of a Chromosome 17-Linked Autosomal Dominant Parkinsonism and Dementia (“Pallido-Ponto-Nigral Degeneration”)

1998 • 142 citations

Polymerization of tau peptides into fibrillar structures. The effect of FTDP‐17 mutations

1999 • 120 citations

Altered conformation of recombinant frontotemporal dementia-17 mutant tau proteins

1999 • 46 citations