Plugging it in: signaling circuits and the yeast cell cycle

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1994 • 1,520 citations

Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: Regulation by starvation and RAS

1992 • 1,184 citations

MAP kinase pathways in yeast: For mating and more

1995 • 1,009 citations

Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.

1994 • 759 citations

Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

1995 • 758 citations

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.

1994 • 616 citations

A checkpoint regulates the rate of progression through S phase in S. cerevisiae in Response to DNA damage

1995 • 596 citations

Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins.

1993 • 509 citations

Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids

1993 • 505 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1

1995 • 370 citations

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.

1995 • 365 citations

Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae.

1995 • 337 citations

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

1994 • 329 citations

Regulation of p34CDC28 tyrosine phosphorylation is not required for entry into mitosis in S. cerevisiae

1992 • 296 citations

S-phase feedback control in budding yeast independent of tyrosine phosphorylation of P34cdc28

1992 • 290 citations

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

1993 • 290 citations

A cell cycle checkpoint monitors cell morphogenesis in budding yeast.

1995 • 267 citations

Direct Inhibition of the Yeast Cyclin-Dependent Kinase Cdc28-Cln by Far1

1994 • 258 citations

Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae.

1994 • 256 citations

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia.

1994 • 253 citations

Cell cycle control of morphogenesis in budding yeast

1995 • 235 citations

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway

1995 • 209 citations

Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin

1995 • 209 citations

The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex.

1989 • 206 citations

G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast.

1995 • 204 citations

SOK2 May Regulate Cyclic AMP-Dependent Protein Kinase-Stimulated Growth and Pseudohyphal

1995 • 195 citations

Pheromone Signalling in Saccharomyces cerevisiae Requires the Small GTP-Binding Protein Cdc42p and Its Activator CDC24

1995 • 192 citations

CLN3, not positive feedback, determines the timing of CLN2 transcription in cycling cells.

1995 • 187 citations

Inhibition of Gl cyclin activity by the Ras/cAMP pathway in yeast

1994 • 185 citations

Molecular Characterization of Ste20p, a Potential Mitogen-activated Protein or Extracellular Signal-regulated Kinase Kinase (MEK) Kinase Kinase from Saccharomyces cerevisiae

1995 • 174 citations

Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p

1995 • 173 citations

Repression of growth-regulated Gl cyclin expression by cyclic AMP in budding yeast

1994 • 149 citations

Negative regulation of FAR1 at the Start of the yeast cell cycle.

1993 • 148 citations

The genetics of cell cycle checkpoints

1995 • 143 citations

The RAS-adenylate cyclase pathway and cell cycle control inSaccharomyces cerevisiae

1992 • 138 citations

Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae.

1995 • 134 citations

The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5.

1994 • 129 citations

Glucose-Induced Hyperaccumulation of Cyclic AMP and Defective Glucose Repression in Yeast Strains with Reduced Activity of Cyclic AMP-Dependent Protein Kinase

1990 • 105 citations

Nutrient Availability and the RAS/Cyclic AMP Pathway Both Induce Expression of Ribosomal Protein Genes in Saccharomyces cerevisiae but by Different Mechanisms

1995 • 104 citations

Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia.

1995 • 89 citations

Control of cellular morphogenesis by the Ip12/Bem2 GTPase-activating protein: possible role of protein phosphorylation.

1994 • 88 citations

Full activation of p34CDC28 histone H1 kinase activity is unable to promote entry into mitosis in checkpoint-arrested cells of the yeast Saccharomyces cerevisiae.

1993 • 87 citations

Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase.

1990 • 77 citations

Cell size modulation by CDC25 and RAS2 genes in Saccharomyces cerevisiae.

1989 • 71 citations

Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest.

1992 • 65 citations

Connections between the Ras-cyclic AMP pathway and G1 cyclin expression in the budding yeast Saccharomyces cerevisiae.

1993 • 64 citations

Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae.

1995 • 63 citations

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Farl

1993 • 59 citations

Signal transduction and growth control in yeast

1995 • 55 citations

cAMP-mediated increase in the critical cell size required for the G1 to S transition in Saccharomyces cerevisiae

1992 • 36 citations

Suppressors reveal two classes of glucose repression genes in the yeast Saccharomyces cerevisiae.

1994 • 35 citations