Comparison of kinetic properties between two mammalian ras p21 GDP/GTP exchange proteins, ras guanine nucleotide-releasing factor and smg GDP dissociation stimulation.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

ras GENES

1987 • 3,818 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

[16] Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes

1974 • 1,028 citations

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 • 1,026 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 • 587 citations

Small GTP-Binding Proteins

1992 • 526 citations

Rapid and efficient purification of native histidine-tagged protein expressed by recombinant vaccinia virus.

1991 • 464 citations

Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21

1992 • 361 citations

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.

1990 • 333 citations

Modulation of guanine nucleotides bound to Ras in NIH3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)

1990 • 305 citations

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

1992 • 286 citations

Platelet-derived growth factor stimulates formation of active p21ras.GTP complex in Swiss mouse 3T3 cells.

1990 • 282 citations

Cloning by functional complementation of a mouse cDNA encoding a homologue of CDC25, a Saccharomyces cerevisiae RAS activator.

1992 • 234 citations

Purification and characterization of a novel GTP-binding protein with a molecular weight of 24,000 from bovine brain membranes.

1988 • 207 citations

A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21.

1991 • 202 citations

Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.

1993 • 174 citations

Purification and characterization from bovine brain cytosol of proteins that regulate the GDP/GTP exchange reaction of smg p21s, ras p21-like GTP-binding proteins.

1990 • 154 citations

Post-translational processing of rac p21s is important both for their interaction with the GDP/GTP exchange proteins and for their activation of NADPH oxidase.

1992 • 147 citations

Influence of guanine nucleotides on complex formation between Ras and CDC25 proteins.

1993 • 147 citations

Both stimulatory and inhibitory exchange proteins, smg GDS and rho GDI, are active on multiple small GTP-binding proteins

1992 • 116 citations

Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein.

1991 • 110 citations

Identification of a mammalian gene structurally and functionally related to the CDC25 gene of Saccharomyces cerevisiae.

1992 • 91 citations

The post-translational processing of ras p21 is critical for its stimulation of mitogen-activated protein kinase.

1993 • 75 citations

A protein factor for ras p21-dependent activation of mitogen-activated protein (MAP) kinase through MAP kinase kinase.

1993 • 73 citations

Preparation of anti-ras Mr 21,000 protein monoclonal antibodies and immunohistochemical analyses on expression of ras genes in human stomach and thyroid cancers.

1988 • 58 citations

Inhibition of the action of the stimulatory GDP/GTP exchange protein for smg p21 by the geranylgeranylated synthetic peptides designed from its C-terminal region.

1991 • 40 citations

Translocation of Ki-ras P21 between Membrane and Cytoplasm by smg GDS

1993 • 23 citations