The significance of DNA and protein adducts in human biomonitoring studies

Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations

1983 • 719 citations

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

1964 • 687 citations

ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE

1961 • 576 citations

Mechanisms of chemical carcinogenesis

1981 • 424 citations

In vivo covalent binding of organic chemicals to DNA as a quantitative indicator in the process of chemical carcinogenesis

1979 • 412 citations

Malignant conversion of mouse skin tumours is increased by tumour initiators and unaffected by tumour promoters

1983 • 325 citations

Molecular epidemiology and carcinogen-DNA adduct detection: New approaches to studies of human cancer causation

1982 • 319 citations

Evaluation of genetic risks of alkylating agents: Tissue doses in the mouse from air contaminated with ethylene oxide

1974 • 313 citations

Chemical Carcinogenesis: From Animal Models To Molecular Models In One Decade

1988 • 270 citations

Detection of Smoking-Related Covalent DNA Adducts in Human Placenta

1986 • 261 citations

Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers.

1987 • 259 citations

Formation and persistence of arylamine DNA adducts in vivo.

1985 • 214 citations

Toxicology. The basic science of poisons

1976 • 195 citations

Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers.

1985 • 190 citations

Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere.

1986 • 167 citations

A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene — DNA adducts in animal and human tissues by immunoassays

1982 • 167 citations

0⁶‐Methyldeoxyguanosine in oesophageal dna among individuals at high risk of oesophageal cancer

1985 • 163 citations

Analysis of hemoglobin as a dose monitor for alkylating and arylating agents

1984 • 157 citations

Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

1986 • 155 citations

Monitoring and risk assessment by means of alkyl groups in hemoglobin in persons occupationally exposed to ethylene oxide.

1978 • 154 citations

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

1984 • 154 citations

Tissue doses of ethylene oxide in cigarette smokers determined from adduct levels in hemoglobin

1986 • 151 citations

Dosimetry of genotoxic agents and dose-response relationships of their effects

1983 • 150 citations

DNA binding and mutation spectra of the carcinogen N-2-aminofluorene in Escherichia coli

1985 • 146 citations

Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C]- and [3H]formaldehyde

1984 • 132 citations

Molecular cancer epidemiology: a new tool in cancer prevention.

1987 • 131 citations

Detection of benzo(a)pyrene:DNA adducts in human white blood cells.

1985 • 130 citations

DNA Adducfs, Protein Adducts, and Sister Chromatid Exchange in Cigarette Smokers and Nonsmokers<xref ref-type="fn" rid="FN2">2</xref>

1987 • 126 citations

Chemical and biochemical dosimetry of exposure to genotoxic chemicals.

1985 • 122 citations

Monitoring human exposure to carcinogenic and mutagenic agents

1986 • 119 citations

Formation and persistence of benzo(a)pyrene metabolite-DNA adducts.

1985 • 117 citations

Quantitative evaluation of DNA binding data for risk estimation and for classification of direct and indirect carcinogens

1986 • 115 citations

Multistage carcinogenesis involves multiple genes and multiple mechanisms

1984 • 111 citations

Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes

1986 • 107 citations

Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1986 • 107 citations

Monitoring human exposure to ethylene oxide by the determination of haemoglobin adducts using gas chromatography—mass spectrometry

1986 • 101 citations

Relationships between DNA adduct formation and carcinogenesis.

1985 • 97 citations

Neoplastic progression in expreimental hepatocarcinogenesis

1984 • 95 citations

Formation of benzo(a)pyrene/DNA adducts and their relationship to tumor initiation in mouse epidermis.

1983 • 91 citations

Quantitative comparison of carcinogenicity, mutagenicity and electrophilicity of 10 direct-acting alkylating agents and of the initial O6: 7-alkylguanine ratio in DNA with carcinogenic potency in rodents

1983 • 91 citations

Effect of dose fractionation on the ethylnitrosourea induction of specific-locus mutations in mouse spermatogonia.

1982 • 88 citations

Monitoring of Occupational Genotoxicants

1987 • 85 citations

Induced Mutagenesis: Molecular Mechanisms and their Implications for Environmental Protection

1984 • 84 citations

Application of new techniques for the detection of carcinogen adducts to human population monitoring

1988 • 84 citations

Cell selective alkylation of DNA in rat lung following low dose exposure to the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

1987 • 81 citations

Persistence of DNA adducts in rat liver and kidney after multiple doses of the carcinogen N-hydroxy-2-acetylaminofluorene.

1982 • 80 citations

Cytogenetic, immunological, and haematological effects in workers in an ethylene oxide manufacturing plant.

1985 • 76 citations

Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia.

1987 • 72 citations

Detection of putative adduct with fluorescence characteristics identical to 2,3-dihydro-2-(7′-guanyl)-3-hydroxyaflatoxin B₁ in human urine collected in Murang'a district, Kenya

1983 • 71 citations

Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: Nature and extent of the associated hydrocarbon-DNA reaction

1977 • 71 citations

Host factors in human carcinogenesis

1983 • 67 citations

Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: relationship of DNA binding to initiation of skin carcinogenesis.

1984 • 65 citations

The use of carcinogen‐DNA adduct antisera for quantitation and localization of genomic damage in animal models and the human population

1984 • 62 citations

Future directions in the use of DNA adducts as internal dosimeters for monitoring human exposure to environmental mutagens and carcinogens.

1985 • 59 citations

Alkylation of nucleic acids and metabolism of small doses of dimethylnitrosamine in the rat.

1981 • 57 citations

³²P-Postlabelling analysis of aromatic DNA adducts in human oral mucosal cells

1986 • 56 citations

Benzo[a]pyrene diol-epoxides different mutagenic efficiency in human and bacteria cells

1985 • 51 citations

Inhibition in vivo of the formation of adducts between metabolites of benzo(a)pyrene and DNA by butylated hydroxyanisole.

1981 • 51 citations

86th Annual Meeting of the American Association for Cancer Research

1995 • 50 citations

Monitoring exposure to propylene oxide through the determination of hemoglobin alkylation.

1984 • 48 citations

Dose-Response Relationship in the Primary Lesion of Strong Electrophilic Carcinogens

1980 • 44 citations

DNA adduct formation and mutation induction by nitropyrenes in Salmonella and Chinese hamster ovary cells: relationships with nitroreduction and acetylation.

1985 • 41 citations

Formation of DNA modifications by chemical carcinogens Identification, localization and quantification

1984 • 38 citations

Wide-range linear dose-response curve for DNA binding of orally administered benzo(a)pyrene in mice.

1983 • 37 citations

Dose-dependency of 2-acetylaminofluorene binding to liver DNA and hemoglobin in mice and rats

1981 • 35 citations

Formation and persistence of sterigmatocystin--DNA adducts in rat liver determined via 32P-postlabeling analysis.

1985 • 34 citations

Host Factors in Human Carcinogenesis

1984 • 34 citations

Killing and mutation of human lymphoblast cells by aflatoxin B1: evidence for an inducible repair response.

1987 • 33 citations

Formation and persistence of sterigmatocystin-DNA adducts in rat liver determined via 32P-postlabeling analysis

1985 • 31 citations

Dosimetry and dose-response relationships.

1984 • 31 citations

Kinetics of formation and persistence of ethylguanines in DNA of rats and hamsters treated with diethylnitrosamine.

1985 • 30 citations

Binding of polycyclic aromatic hydrocarbons to DNA: Comparison with mutagenesis and tumorigenesis

1980 • 29 citations

Chemical dosimetry of ethyl nitrosourea in the mouse testis

1986 • 27 citations

Relationships between ethylation of hemoglobin, ethylation of DNA and administered amount of ethyl methanesulfonate in the mouse

1984 • 27 citations

Immunochemical visualization of binding of the chemical carcinogen benzo(a)pyrene diol-epoxide 1 to the genome.

1981 • 27 citations

Methylated DNA adducts in the large intestine of ICR/Ha and C57BL/Ha mice given 1,2-dimethylhydrazine.

1983 • 27 citations

Cytotoxicity, cellular transformation and DNA adducts in normal human diploid fibroblasts exposed to 1-nitrosopyrene, a reduced derivative of the environmental contaminant, 1-nitropyrene

1986 • 25 citations

Interindividual human variation in cisplatinum sensitivity, predictable in an in vitro assay?

1987 • 24 citations

Cell‐mediated mutagenesis in cultured chinese hamster cells by polycyclic hydrocarbons: Mutagenicity and DNA reaction related to carcinogenicity in a series of compounds

1979 • 21 citations

Biological aspects to the evaluation of risk: Dosimetry of carcinogens in man

1984 • 21 citations

Metabolism and DNA adduct formation of 2-acetylaminofluorene by bladder explants from human, dog, monkey, hamster and rat

1984 • 20 citations

Role of Extent and Persistence of DNA Modifications in Chemical Carcinogenesis by Aromatic Amines

1983 • 19 citations

DNA adducts in experimental cancer research

1986 • 19 citations

Analysis of Chemically Induced Mutation in Single Cell Populations

1983 • 17 citations

Long-term, low-dose benzo[α]pyrene-induced mutation in human lymphoblasts competent in xenobiotic metabolism

1989 • 15 citations

4-hydroxyaminoquinoline 1-oxide metabolism and DNA adducts in the early stage of tumorigenesis in rats: Comparison of target organ pancreas with non-target organ liver

1985 • 14 citations

Molecular dosimetry techniques in human risk assessment: an industrial perspective.

1983 • 13 citations

Determination of Carcinogen-Induced Macromolecular Adducts in Animals and Humans

2015 • 13 citations

Covalent binding of 7,12-dimethylbenz(a)anthracene and 10-fluoro-7,12-dimethylbenz(a)anthracene to mouse epidermal DNA and its relationship to tumor-initiating activity.

1985 • 13 citations

Use of alkylated proteins in the monitoring of exposure to alkylating agents.

1984 • 12 citations

Non-random binding of N-acetoxy-N-2-acetylaminofluorene to chromatin subunits as visualized by immunoelectron microscopy

1982 • 11 citations

Alkylation-induced mutagenesis in higher eukaryotic systems: significance of DNA modifications and DNA repair with regard to genetic endpoints.

1986 • 11 citations

Cytotoxic and mutagenic effects of specific carcinogen-DNA adducts in diploid human fibroblasts.

1985 • 11 citations

Methods of monitoring human exposure to carcinogenic and mutagenic agents.

1984 • 10 citations

Mutation induction and DNA adduct formation by 1,8-dinitropyrene in Chinese hamster ovary cells.

1986 • 9 citations

Biomonitoring of chemicals and their metabolites.

1984 • 9 citations

Hemoglobin as a dose monitor and its application to the risk estimation of ethylene oxide

1984 • 9 citations

Future perspectives, needs and expectations of biological monitoring of exposure to genotoxicants in prevention of occupational disease.

1986 • 6 citations

Macromolecule adducts, target dose and risk assessment.

1986 • 5 citations

Biomonitoring of cisplatin-DNA adducts in cancer patients receiving cisplatin chemotherapy.

1986 • 2 citations