Spider Neurotoxins Targeting Voltage-Gated Sodium Channels

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Molecular mechanisms of neurotoxin action on voltage-gated sodium channels

2000 • 714 citations

Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels

1996 • 603 citations

Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels

2000 • 463 citations

Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

1995 • 456 citations

Crystal Structure of the Extracellular Domain from P0, the Major Structural Protein of Peripheral Nerve Myelin

1996 • 412 citations

Selective Peptide Antagonist of the Class E Calcium Channel from the Venom of the TarantulaHysterocrates gigas

1998 • 404 citations

Sodium Channel β4, a New Disulfide-Linked Auxiliary Subunit with Similarity to β2

2003 • 380 citations

Pharmacology and biochemistry of spider venoms

2002 • 335 citations

Voltage Sensor–Trapping

1998 • 328 citations

The cystine knot structure of ion channel toxins and related polypeptides

1998 • 302 citations

Structure and pharmacology of spider venom neurotoxins

2000 • 251 citations

Two Tarantula Peptides Inhibit Activation of Multiple Sodium Channels

2002 • 224 citations

Functional Expression ofDrosophila paraSodium Channels

1997 • 208 citations

Covalent labeling of protein components of the sodium channel with a photoactivable derivative of scorpion toxin.

1980 • 199 citations

THE INSECT VOLTAGE-GATED SODIUM CHANNEL AS TARGET OF INSECTICIDES

1999 • 194 citations

Functional Anatomy of Scorpion Toxins Affecting Sodium Channels

1998 • 193 citations

Were arachnids the first to use combinatorial peptide libraries?

2004 • 193 citations

Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis aperta

1989 • 167 citations

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca ²⁺ and K ⁺ channels

1998 • 165 citations

The multiple actions of black widow spider toxins and their selective use in neurosecretion studies

2004 • 140 citations

Function and Solution Structure of Huwentoxin-IV, a Potent Neuronal Tetrodotoxin (TTX)-sensitive Sodium Channel Antagonist from Chinese Bird Spider Selenocosmia huwena

2002 • 139 citations

Agatoxins: ion channel specific toxins from the american funnel web spider, Agelenopsis aperta

2004 • 127 citations

The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel

1997 • 117 citations

Non-synaptic ion channels in insects — basic properties of currents and their modulation in neurons and skeletal muscles

2001 • 115 citations

Two classes of channel-specific toxins from funnel web spider venom

1989 • 108 citations

Distinct primary structures of the major peptide toxins from the venom of the spider Macrothele gigas that bind to sites 3 and 4 in the sodium channel¹

2003 • 102 citations

Molecular Basis of the High Insecticidal Potency of Scorpion α-Toxins

2004 • 102 citations

Two sodium-channel genes in Drosophila: implications for channel diversity.

1989 • 98 citations

AaIT: From neurotoxin to insecticide

2000 • 94 citations

Purification and amino acid sequence of the insecticidal neurotoxin T×4(6-1) from the venom of the ‘armed’ spider Phoneutria nigriventer (keys)

1995 • 89 citations

Clockwise Domain Arrangement of the Sodium Channel Revealed by ¼-Conotoxin (GIIIA) Docking Orientation

2001 • 87 citations

Neurotoxins from Plectreurys spider venom are potent presynaptic blockers in Drosophila

1987 • 86 citations

Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta.

1990 • 86 citations

Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation

1998 • 83 citations

Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel‐web spider Atrax robustus

1985 • 81 citations

Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spiderHadronyche versuta

1994 • 78 citations

Purification and physiological characterization of neurotoxins from venoms of the scorpions centruroides sculpturatus and leiurus quinquestriatus.

1983 • 78 citations

Effects of a toxic fraction, PhTx2, from the spider Phoneutria nikriventer on the sodium current

1993 • 77 citations

Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus

1988 • 77 citations

Three-Dimensional Structure Analysis of μ-Agatoxins: Further Evidence for Common Motifs among Neurotoxins with Diverse Ion Channel Specificities

1996 • 75 citations

Structure and function of δ-atracotoxins: lethal neurotoxins targeting the voltage-gated sodium channel

2004 • 74 citations

Function and solution structure of hainantoxin‐I, a novel insect sodium channel inhibitor from the Chinese bird spider Selenocosmia hainana¹

2003 • 73 citations

Jingzhaotoxin-I, a Novel Spider Neurotoxin Preferentially Inhibiting Cardiac Sodium Channel Inactivation

2004 • 72 citations

Isolation, synthesis and pharmacological characterization of δ‐palutoxins IT, novel insecticidal toxins from the spider Paracoelotes luctuosus (Amaurobiidae)

2000 • 71 citations

STRUCTURE AND FUNCTION OF INSECTICIDAL NEUROTOXINS FROM AUSTRALIAN FUNNEL-WEB SPIDERS

2002 • 71 citations

Solution structure of robustoxin, the lethal neurotoxin from the funnel‐web spider Atrax robustus

1997 • 69 citations

Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities

1995 • 68 citations

Jingzhaotoxin-III, a Novel Spider Toxin Inhibiting Activation of Voltage-gated Sodium Channel in Rat Cardiac Myocytes

2004 • 67 citations

Toxins and signal transduction

1998 • 67 citations

Inhibition of neuronal tetrodotoxin-sensitive Na+ channels by two spider toxins: hainantoxin-III and hainantoxin-IV

2003 • 66 citations

Dissection of the Functional Surface of an Anti-insect Excitatory Toxin Illuminates a Putative “Hot Spot” Common to All Scorpion β-Toxins Affecting Na+ Channels

2004 • 66 citations

δ‐Atracotoxins from Australian funnel‐web spiders compete with scorpion α‐toxin binding on both rat brain and insect sodium channels

1998 • 65 citations

Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers

2004 • 64 citations

SNX482 selectively blocks P/Q Ca2+ channels and delays the inactivation of Na+ channels of chromaffin cells

2003 • 59 citations

Isolation and pharmacological characterisation of δ‐atracotoxin‐Hv1b, a vertebrate‐selective sodium channel toxin

2000 • 58 citations

The toxin Tx4(6-1) from the spider Phoneutria nigriventer slows down Na+ current inactivation in insect CNS via binding to receptor site 3

2002 • 58 citations

Electrophysiological characterization and molecular identification of the Phoneutria nigriventer peptide toxin PnTx2‐6¹

2002 • 53 citations

δ-Atracotoxins from Australian Funnel-web Spiders Compete with Scorpion α-Toxin Binding but Differentially Modulate Alkaloid Toxin Activation of Voltage-gated Sodium Channels

1998 • 46 citations

A new approach to insect-pest control—combination of neurotoxins interacting with voltage sensitive sodium channels to increase selectivity and specificity

1997 • 44 citations

Cross-reactivity of Sydney funnel-web spider antivenom: neutralization of the in vitro toxicity of other Australian funnel-web (Atrax and Hadronyche) spider venoms

2002 • 41 citations

Electrophysiological analysis of the neurotoxic action of a funnel-web spider toxin, delta-atracotoxin-HV1a, on insect voltage-gated Na+ channels

2001 • 40 citations

Effects of Simultaneous Expression of Two Sodium Channel Toxin Genes on the Properties of Baculoviruses as Biopesticides

1998 • 39 citations

A Spider Toxin That Induces a Typical Effect of Scorpion α-Toxins but Competes with β-Toxins on Binding to Insect Sodium Channels

2005 • 38 citations

Solution Structures of the cis- and trans-Pro30 Isomers of a Novel 38-Residue Toxin from the Venom of Hadronyche Infensa sp. that Contains a Cystine-Knot Motif within Its Four Disulfide Bonds^,

2002 • 35 citations

Isolation of δ‐missulenatoxin‐Mb1a, the major vertebrate‐active spider δ‐toxin from the venom of Missulena bradleyi (Actinopodidae)¹

2003 • 34 citations

Properties of the Venom from the South American ‘‘Armed'’ Spider Phoneutria Nigriventer (Keyserling, 1891)

1995 • 33 citations

Severe Lung Oedema and Fatal Consumption Coagulopathy after Funnel‐Web Bite

1980 • 32 citations

Mode of action of an insecticidal peptide toxin from the venom of a weaving spider (Diguetia canities)

1996 • 32 citations

Solution structure of two insect‐specific spider toxins and their pharmacological interaction with the insect voltage‐gated Na⁺ channel

2005 • 31 citations

Variations in receptor site‐3 on rat brain and insect sodium channels highlighted by binding of a funnel‐web spider δ‐atracotoxin

2002 • 31 citations

Purification and characterization of Hainantoxin-V, a tetrodotoxin-sensitive sodium channel inhibitor from the venom of the spider Selenocosmia hainana

2003 • 29 citations

Synthesis and Characterization of δ-Atracotoxin-Ar1a, the Lethal Neurotoxin from Venom of the Sydney Funnel-Web Spider (Atrax robustus)

2003 • 27 citations

Mechanism of modulation of single sodium channels from skeletal muscle by the ? 1-subunit from rat brain

1994 • 26 citations

omega-Toxins affect Na+ currents in neurosecretory insect neurons.

1998 • 17 citations