THE INSECT VOLTAGE-GATED SODIUM CHANNEL AS TARGET OF INSECTICIDES

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable Membranes

1980 • 1,236 citations

Auxiliary subunits of voltage-gated ion channels

1994 • 561 citations

Identification of mutations in the houseflypara-type sodium channel gene associated with knockdown resistance (kdr) to pyrethroid insecticides

1996 • 531 citations

Molecular analysis of the para locus, a sodium channel gene in Drosophila

1989 • 501 citations

Neuronal Ion Channels as the Target Sites of Insecticides

1996 • 421 citations

Molecular Determinants of High Affinity Binding of α-Scorpion Toxin and Sea Anemone Toxin in the S3-S4 Extracellular Loop in Domain IV of the Na+ Channel α Subunit

1996 • 410 citations

Neurotoxicological Effects and the Mode of Action of Pyrethroid Insecticides

1990 • 404 citations

Ion Channels as Targets for Insecticides

1996 • 403 citations

Molecular biology of insecticide resistance

1995 • 283 citations

Genomic Organization and Deduced Amino Acid Sequence of a Putative Sodium Channel Gene in Drosophila

1987 • 244 citations

Nerve membrane Na+ channels as targets of insecticides

1992 • 243 citations

An Integrated view of the Molecular Toxinology of Sodium Channel Gating in Excitable Cells

1987 • 221 citations

The Biochemistry and Uses of Pesticides

1990 • 219 citations

Knockdown resistance (kdr) to DDT and pyrethroid insecticides maps to a sodium channel gene locus in the housefly (Musca domestica)

1993 • 214 citations

Development of a Recombinant Baculovirus Expressing an Insect-Selective Neurotoxin: Potential for Pest Control

1991 • 210 citations

Cloning and functional analysis of tipE, a novel membrane protein that enhances drosophila para sodium channel function

1995 • 208 citations

Functional Expression ofDrosophila paraSodium Channels

1997 • 208 citations

A single amino acid change in the para sodium channel protein is associated with knockdown-resistance (kdr) to pyrethroid insecticides in German cockroach

1997 • 201 citations

Field trial of a genetically improved baculovirus insecticide

1994 • 184 citations

Restoration of inactivation and block of open sodium channels by an inactivation gate peptide

1994 • 165 citations

A new neurotoxin receptor site on sodium channels is identified by a conotoxin that affects sodium channel inactivation in molluscs and acts as an antagonist in rat brain.

1994 • 122 citations

Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin.

1996 • 106 citations

Developmentally regulated alternative splicing generates a complex array of Drosophila para sodium channel isoforms

1994 • 104 citations

Linkage of pyrethroid insecticide resistance to a sodium channel locus in the tobacco budworm

1993 • 103 citations

Two sodium-channel genes in Drosophila: implications for channel diversity.

1989 • 98 citations

Interaction of insecticides of the pyrethroid family with specific binding sites on the voltage-dependent sodium channel from mammalian brain

1988 • 89 citations

Baculovirus‐mediated expression of a scorpion depressant toxin improves the insecticidal efficacy achieved with excitatory toxins

1998 • 86 citations

Pyrethroid receptor in the insect sodium channel: alteration of its properties in pyrethroid-resistant flies

1989 • 86 citations

Pharmacological properties of insect axons: A review

1982 • 82 citations

Pyrethroids, nerve poisons: how their risks to human health should be assessed

1995 • 81 citations

High Affinity Binding of Pyrethroids to the α Subunit of Brain Sodium Channels

1997 • 80 citations

Structure-Function Studies of Voltage-Gated Ion Channels

1991 • 71 citations

Molecular Mechanisms of Insecticide Resistance

1992 • 70 citations

Spatial and temporal expression patterns of two sodium channel genes in Drosophila

1994 • 69 citations

Sodium current density correlates with expression of specific alternatively spliced sodium channel mRNAs in single neurons

1995 • 62 citations

Interactions of tetramethrin, fenvalerate and DDT at the sodium channel in rat dorsal root ganglion neurons

1996 • 62 citations

Properties of Three Baculovirus-Expressing Genes That Encode Insect-Selective Toxins: μ-Aga-IV, As II, and Sh I

1996 • 59 citations

Mode of action of insecticidal dihydropyrazoles: Selective block of impulse generation in sensory nerves

1990 • 59 citations

Molecular Action of Insecticides on Ion Channels

1995 • 58 citations

Interactions of Recombinant and Wild-Type Baculoviruses with Classical Insecticides and Pyrethroid-Resistant Tobacco Budworm (Lepidoptera: Noctuidae)

1997 • 58 citations

Total D-amino and other free amino acids increase in the muscle of crayfish during seawater acclimation

1994 • 54 citations

Slow voltage-dependent block of sodium channels in crayfish nerve by dihydropyrazole insecticides.

1992 • 52 citations

Positive cooperativity among insecticidal scorpion neurotoxins

1995 • 49 citations

Variability among insect sodium channels revealed by selective neurotoxins

1994 • 40 citations

Sodium channel polypeptides in central nervous systems of various insects identified with site directed antibodies

1990 • 39 citations

Purification and characterization of insect toxins derived from the mite, Pyemotes tritici

1989 • 39 citations

Immobilization of sodium channel gating charge in crayfish giant axons by the insecticide fenvalerate.

1993 • 36 citations

Identification of mutations in the housefly para -type sodium channel gene associated with knockdown resistance ( kdr ) to pyrethroid insecticides

1996 • 35 citations

Mode of action of an insecticidal peptide toxin from the venom of a weaving spider (Diguetia canities)

1996 • 32 citations

RH 3421, an insecticidal dihydropyrazole, inhibits sodium channel-dependent sodium uptake in mouse brain preparations

1991 • 32 citations

The tolerance of lepidopterous larvae to an insect selective neurotoxin

1990 • 32 citations

Insect Sodium Channel as the Target for Insect-Selective Neurotoxins from Scorpion Venom

1995 • 20 citations

PCR-based phylogenetic walking: Isolation of para-homologous sodium channel gene sequences from seven insect species and an arachnid

1991 • 20 citations

Action of insecticidal N-alkylamides at site 2 of the voltage-sensitive sodium channel

1990 • 19 citations

Insect Tolerance to A Neurotoxic Polypeptide: Pharmacokinetic and Pharmacodynamic Aspects

1997 • 15 citations

Apparent reduction in the number of nerve membrane sodium channels in the house fly in relation to metabolic resistance to insecticides

1991 • 13 citations

An Integrated View Of The Molecular Toxinology Of Sodium Channel Gating In Excitable Cells

1987 • 10 citations

Characterization of a Cytochrome P450 Responsible for Pyrethroid Resistance in the Housefly

1992 • 9 citations

Dihydropyrazole Insecticides: Interference with Depolarization-Dependent Phosphorylation of Synapsin I and Evoked Release ofl-Glutamate in Nerve-Terminal Preparations from Mammalian Brain

1996 • 7 citations

Actions of Insecticides on Sodium Channels

1995 • 6 citations

Presynaptic Actions of Dihydropyrazoles

1995 • 4 citations

Ionic Basis of Electrical Activity in Insect Nerve Cells and Synapses

1984 • 1 citations