Structure and pharmacology of spider venom neurotoxins

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

1992 • 877 citations

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.

1989 • 631 citations

Molecular diversity of voltage-dependent Ca2+ channels

1991 • 600 citations

H+-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels

1998 • 508 citations

A common structural motif incorporating a cystine knot and a triple‐stranded β‐sheet in toxic and inhibitory polypeptides

1994 • 504 citations

Interactions of polyamines with ion channels

1997 • 493 citations

Isolation of a Tarantula Toxin Specific for a Class of Proton-gated Na+ Channels

2000 • 463 citations

Molecular biology of voltage-dependent potassium channels

1992 • 412 citations

Selective Peptide Antagonist of the Class E Calcium Channel from the Venom of the TarantulaHysterocrates gigas

1998 • 404 citations

Conus geographus toxins that discriminate between neuronal and muscle sodium channels.

1985 • 402 citations

Receptor sites for Ca2+ channel antagonists

1992 • 382 citations

Structure and function of voltage‐gated sodium channels

1998 • 349 citations

Structural Elements Involved in Specific K+ Channel Functions

1992 • 268 citations

Structural basis of drug binding to L Ca2+ channels

1998 • 265 citations

An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula

1995 • 254 citations

Hanatoxin Modifies the Gating of a Voltage-Dependent K+ Channel through Multiple Binding Sites

1997 • 239 citations

Mapping the Receptor Site for Hanatoxin, a Gating Modifier of Voltage-Dependent K+ Channels

1997 • 221 citations

Kalicludines and Kaliseptine

1995 • 201 citations

Discovery and characterization of a family of insecticidal neurotoxins with a rare vicinal disulfide bridge

2000 • 200 citations

Sea Anemone Peptides with a Specific Blocking Activity against the Fast Inactivating Potassium Channel Kv3.4

1998 • 198 citations

Heteropodatoxins: peptides isolated from spider venom that block Kv4.2 potassium channels.

1997 • 190 citations

The structure of a novel insecticidal neurotoxin, ω-atracotoxin-HV1, from the venom of an Australian funnel web spider

1997 • 175 citations

Sphingomyelinases in the Venom of the SpiderLoxosceles intermediaAre Responsible for both Dermonecrosis and Complement-Dependent Hemolysis

1998 • 169 citations

Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis aperta

1989 • 167 citations

Gating modifier toxins reveal a conserved structural motif in voltage-gated Ca ²⁺ and K ⁺ channels

1998 • 165 citations

Effects of phrixotoxins on the Kv4 family of potassium channels and implications for the role of I_to1 in cardiac electrogenesis

1999 • 154 citations

Purification and amino acid sequences of six Tx3 type neurotoxins from the venom of the Brazilian ‘armed’ spider Phoneutria Nigriventer (keys.)

1993 • 148 citations

Solution structure of hanatoxin1, a gating modifier of voltage-dependent K+ channels: common surface features of gating modifier toxins

2000 • 145 citations

Functional Consequences of Posttranslational Isomerization of Ser ⁴⁶ in a Calcium Channel Toxin

1994 • 144 citations

Structure of alpha-latrotoxin oligomers reveals that divalent cation-dependent tetramers form membrane pores.

2000 • 137 citations

Vesicle exocytosis stimulated by α-latrotoxin is mediated by latrophilin and requires both external and stored Ca2+

1998 • 130 citations

Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom.

1990 • 125 citations

The structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel

1997 • 117 citations

Black widow spider toxins: the present and the future

1998 • 113 citations

Chemical characterization of spider toxin, JSTX and NSTX.

1986 • 111 citations

Isolation and pharmacological characterization of omega-grammotoxin SIA, a novel peptide inhibitor of neuronal voltage-sensitive calcium channel responses.

1993 • 109 citations

Two classes of channel-specific toxins from funnel web spider venom

1989 • 108 citations

Isolation of neurotoxic peptides from the venom of the ‘armed’ spider Phoneutria nigriventer

1991 • 107 citations

Isolation and Characterization of a Peptide Isomerase from Funnel Web Spider Venom

1995 • 100 citations

The purification and amino acid sequences of four Tx2 neurotoxins from the venom of the Brazilian ‘armed’ spider Phoneutria nigriventer (Keys)

1992 • 99 citations

Inhibition of N- and L-type Ca2+ channels by the spider venom toxin omega-Aga-IIIA.

1991 • 98 citations

Structure and properties of omega-agatoxin IVB, a new antagonist of P-type calcium channels.

1993 • 97 citations

Combinatorial peptide libraries in drug design: lessons from venomous cone snails

1995 • 96 citations

Neurotoxic acylpolyamines from spider venoms

1993 • 92 citations

Purification and amino acid sequence of the insecticidal neurotoxin T×4(6-1) from the venom of the ‘armed’ spider Phoneutria nigriventer (keys)

1995 • 89 citations

Ca2+-independent insulin exocytosis induced by alpha -latrotoxin requires latrophilin, a G protein-coupled receptor

1998 • 88 citations

Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta.

1990 • 86 citations

Characterisation of the effects of robustoxin, the lethal neurotoxin from the Sydney funnel-web spider Atrax robustus, on sodium channel activation and inactivation

1998 • 83 citations

Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA

1997 • 83 citations

Complete amino acid sequence of a new type of lethal neurotoxin from the venom of the funnel‐web spider Atrax robustus

1985 • 81 citations

Modification of sodium channel gating and kinetics by versutoxin from the Australian funnel-web spiderHadronyche versuta

1994 • 78 citations

5-Hydroxytryptamine content of some arthropod venoms and venom-containing parts

1963 • 78 citations

Effects of a toxic fraction, PhTx2, from the spider Phoneutria nikriventer on the sodium current

1993 • 77 citations

Amino acid sequence of versutoxin, a lethal neurotoxin from the venom of the funnel-web spider Atrax versutus

1988 • 77 citations

Spider toxins selectively block calcium currents in drosophila

1989 • 77 citations

Three-Dimensional Structure Analysis of μ-Agatoxins: Further Evidence for Common Motifs among Neurotoxins with Diverse Ion Channel Specificities

1996 • 75 citations

Voltage-Dependent Inhibition of N- and P-Type Calcium Channels by the Peptide Toxin ω-Grammotoxin-SIA

1997 • 75 citations

Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins.

1992 • 74 citations

Structure and function of cardiac sodium and potassium channels

1997 • 73 citations

High-performance liquid chromatography matrix-assisted laser desorption/ionization time-of-flight mass spectrometry peptide fingerprinting of tarantula venoms in the genusBrachypelma: chemotaxonomic and biochemical applications

1997 • 71 citations

The receptor site for the bee venom mast cell degranulating peptide. Affinity labeling and evidence for a common molecular target for mast cell degranulating peptide and dendrotoxin I, a snake toxin active on potassium channels

1988 • 69 citations

Solution structure of robustoxin, the lethal neurotoxin from the funnel‐web spider Atrax robustus

1997 • 69 citations

Isolation and structure analysis of components from venom of the spider Argiope lobata

1989 • 68 citations

Characterization and cloning of insecticidal peptides from the primitive weaving spider Diguetia canities

1995 • 68 citations

Purification of toxic peptides and the amino acid sequence of CSTX-1 from the multicomponent venom of Cupiennius salei (Araneae:Ctenidae)

1994 • 67 citations

δ‐Atracotoxins from Australian funnel‐web spiders compete with scorpion α‐toxin binding on both rat brain and insect sodium channels

1998 • 65 citations

Polypeptide Toxins as Tools to Study Voltage‐Sensitive Na⁺ Channels^a

1986 • 63 citations

A toxin from the spider Phoneutria nigriventer that blocks calcium channels coupled to exocytosis

1997 • 62 citations

Composition and properties of tarantula Dugesiella hentzi (Girard) venom

1973 • 62 citations

Heterodimeric structure of the spider toxin omega-agatoxin IA revealed by precursor analysis and mass spectrometry.

1992 • 60 citations

Isolation and characterisation of glutamate receptor antagonists from venoms of orb-web spiders

1988 • 59 citations

Sequential assignment and structure determination of spider toxin .omega.-Aga-IVB

1993 • 58 citations

Families of potassium channel genes in mammals: Toward an understanding of the molecular basis of potassium channel diversity

1991 • 58 citations

Paralytic and insecticidal toxins from the funnel web spider, Hololena curta

1991 • 58 citations

The purification and amino acid sequence of the lethal neurotoxin Tx1 from the venom of the Brazilian ‘armed’ spider Phoneutria nigriventer

1990 • 58 citations

Proton Nuclear Magnetic Resonance Studies on Huwentoxin-I from the Venom of the Spider Selenocosmia huwena: 2. Three-Dimensional Structure in Solution

1997 • 56 citations

Tarantula(Eurypelma californicum)Venom, a Multicomponent System

1989 • 55 citations

Structure of paralytic acylpolyamines from the spider Agelenopsisaperta

1990 • 55 citations

Identification of insecticidal peptides from venom of the trap-door spider, Aptostichus schlingeri (Ctenizidae)

1992 • 55 citations

ω-Phonetoxin-IIA: a calcium channel blocker from the spider Phoneutria nigriventer

1998 • 54 citations

Mechanisms of α-latrotoxin action

1999 • 54 citations

Selective alteration of sodium channel gating by Australian funnel-web spider toxins

1996 • 52 citations

SNX-325, a novel calcium antagonist from the spider Segestria florentina

1995 • 52 citations

Isolation and sequencing of insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon)

1994 • 51 citations

Adenosine triphosphate in tarantula spider venoms and its synergistic effect with the venom toxin

1975 • 50 citations

Novel insecticidal peptides fromTegenaria agrestis spider venom may have a direct effect on the insect central nervous system

1998 • 47 citations

Sequence of the cDNA coding for the lethal neurotoxin Tx1 from the Brazilian “armed” spider Phoneutria nigriventer predicts the synthesis and processing of a preprotoxin

1993 • 47 citations

Purification and characterization of huwentoxin‐II, a neurotoxic peptide from the venom of the Chinese bird spider Selenocosmia huwena

1999 • 46 citations

Type III .omega.-Agatoxins: A Family of Probes for Similar Binding Sites on L- and N-Type Calcium Channels

1994 • 45 citations

Chemical characterization of acylpolyamine toxins from venom of a trap-door spider and two tarantulas

1990 • 45 citations

Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain.

1991 • 45 citations

Isolation of a funnel-web spider polypeptide with homology to mamba intestinal toxin 1 and the embryonic head inducer Dickkopf-1

2000 • 45 citations

<b>CHEMICAL STRUCTURE OF JORO SPIDER TOXIN </b><b>(JSTX) </b>

1987 • 44 citations

Cloning, cDNA sequence analysis and patch clamp studies of a toxin from the venom of the armed spider (Phoneutria nigriventer)

1998 • 43 citations

Structure and Total Synthesis of HF-7, a Neuroactive Glyconucleoside Disulfate from the Funnel-Web Spider Hololena curta

1999 • 43 citations

Three-Dimensional Structure of Selenocosmia huwena Lectin-I (SHL-I) from the Venom of the Spider Selenocosmia huwena by 2D-NMR

1999 • 42 citations

α-Latrotoxin Alters Spontaneous and Depolarization-Evoked Quantal Release from Rat Adrenal Chromaffin Cells: Evidence for Multiple Modes of Action

1998 • 42 citations

Inhibition of Neuronal Calcium Channels by a Novel Peptide Spider Toxin, DW13.3

1998 • 40 citations

<b>ISOLATION AND CHEMICAL CHARACTERIZATION OF A SERIES OF NEW SPIDER TOXIN (NEPHILATOXINS) IN THE VENOM OF JORO SPIDER, <i>NEPHILA </i></b><b><i>CLAVATA </i></b>

1988 • 40 citations

Primary structures of two proteins from the venom of the Mexican red knee tarantula (Brachypelma smithii)

1994 • 38 citations

<b>CHEMICAL CHARACTERIZATION OF SPIDER TOXIN, </b><b>NSTX </b>

1987 • 38 citations

Cloning of cDNAs encoding neurotoxic peptides from the spider Phoneutria nigriventer

1998 • 37 citations

Omega-grammotoxin SIA blocks multiple, voltage-gated, Ca2+ channel subtypes in cultured rat hippocampal neurons.

1995 • 36 citations

ω-Agatoxins differentially block calcium channels in locust, chick and rat synaptosomes

1992 • 34 citations

Properties of the Venom from the South American ‘‘Armed'’ Spider Phoneutria Nigriventer (Keyserling, 1891)

1995 • 33 citations

Purification and characterization of tarantula, Dugesiella hentzi (girard) venom Hyaluronidase

1973 • 33 citations

Potassium ion channels : Molecular structure, function, and diseases

1999 • 33 citations

Mode of action of an insecticidal peptide toxin from the venom of a weaving spider (Diguetia canities)

1996 • 32 citations

A comparative study of properties and toxic constituents of funnel web spider (Atrax) venoms

1984 • 31 citations

Characterization and synthesis of a new calcium antagonist from the venom of a fishing spider

1993 • 29 citations

High affinity block of myocardial L-type calcium channels by the spider toxin omega-Aga-toxin IIIA: advantages over 1,4-dihydropyridines.

1992 • 29 citations

Multiple actions of arylalkylamine arthropod toxins on theN-methyl-d-aspartate receptor

1996 • 29 citations

Polyamines in some tarantula venoms

1980 • 29 citations

Chapter 12 Potassium Channels with Two P Domains

1999 • 28 citations

Structures of spider toxins: Hydroxyindole-3-acetylpolyamines and a new generalized structure of type-E compounds obtained from the venom of the Joro spider, Nephila clavata

1998 • 26 citations

Single‐Channel Studies of TTX‐Sensitive and TTX‐Resistant Sodium Channels in Developing Rat Muscle Reveal Different Open Channel Properties^a

1986 • 26 citations

Presence of proteins and glutamate as major constituents of the venom of the spider Araneus gemma

1987 • 24 citations

Potassium Channels with Two Pore Domains

2000 • 22 citations

Two novel peptide neurotoxins from the venom on the tarantula Lasiodora parahybana

1997 • 22 citations

Effects of whole venom and venom fractions from several Australian spiders, including Atrax (Hadronyche) species, when injected into insects

1996 • 20 citations

Molecular cloning and sequencing of cDNAs encoding insecticidal peptides from the primitive hunting spider, Plectreurys tristis (Simon)

1996 • 17 citations

Proton nuclear magnetic resonance studies on huwentoxin-I from the venom of the spiderSelenocosmia huwena: 1. Sequence-specific1H-NMR assignments

1995 • 17 citations

Biochemical analysis of tarantula venom (Eurypelma californicum)

1989 • 17 citations

Identification of bis(agmatine)oxalamide in venom from the primitive hunting spider, Plectreurys tristis (Simon)

1993 • 16 citations

Evidence of mammalian Ca2+ channel inhibitors in venom of the spider Plectreurys tristis

1993 • 15 citations

Effects of the venom of the Theridiid spider, Steatoda capensis Hann, on autonomic transmission in rat isolated atria and caudal artery

1994 • 14 citations

Molecular structures of spider toxins (JSTX-1, 2, 3 and 4) in the venom of Nephila clavata L. Koch

1990 • 13 citations

Identification of noradrenaline in venom from the funnel-web spider Hololena curta

1994 • 12 citations

Comparison of phospholipase activity with direct and indirect lytic effects of animal venoms upon human red cells

1979 • 11 citations

Diversité moléculaire des canaux calciques : du gène à la fonction

1994 • 10 citations

[Isolation and characteristics of the neurotoxin from the spider Segestria florentina].

1985 • 5 citations

Deleted Work

1955 • 0 citations