Agatoxins: ion channel specific toxins from the american funnel web spider, Agelenopsis aperta

The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.

1986 • 1,814 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 920 citations

P-type calcium channels blocked by the spider toxin ω-Aga-IVA

1992 • 877 citations

P-type calcium channels in rat central and peripheral neurons

1992 • 788 citations

Different types of calcium channels mediate central synaptic transmission

1993 • 743 citations

CALCIUM CHANNEL DIVERSITY AND NEUROTRANSMITTER RELEASE: The ω-Conotoxins and ω-Agatoxins

1994 • 734 citations

Systematics and Evolution of Spiders (Araneae)

1991 • 727 citations

Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilizing a toxin fraction (FTX) from funnel-web spider poison.

1989 • 631 citations

Calcium control of transmitter release at a cerebellar synapse

1995 • 532 citations

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor

1989 • 434 citations

Distinctive biophysical and pharmacological properties of class A (BI) calcium channel α1 subunits

1993 • 431 citations

Splicing of α1A subunit gene generates phenotypic variants of P- and Q-type calcium channels

1999 • 425 citations

Selective Peptide Antagonist of the Class E Calcium Channel from the Venom of the TarantulaHysterocrates gigas

1998 • 404 citations

Voltage Sensor–Trapping

1998 • 328 citations

Ion Channels in Presynaptic Nerve Terminals and Control of Transmitter Release

1999 • 296 citations

Exocytotic Ca2+ channels in mammalian central neurons

1995 • 293 citations

Calcium Channels Coupled to Glutamate Release Identified by ω-Aga-IVA

1992 • 292 citations

Multiple Ca2+ channel types coexist to regulate synaptosomal neurotransmitter release.

1993 • 277 citations

A single amino acid determines the subunit-specific spider toxin block of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels.

1993 • 243 citations

Participation of multiple calcium channel types in transmission at single climbing fiber to Purkinje cell synapses

1994 • 214 citations

Modification of sodium channel gating in frog myelinated nerve fibres by Centruroides sculpturatus scorpion venom.

1975 • 194 citations

Block of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors by polyamines and polyamine toxins.

1996 • 172 citations

Purification and Characterization of Two Classes of Neurotoxins from the Funnel Web Spider, Agelenopsis aperta

1989 • 167 citations

Conotoxins.

1991 • 150 citations

Functional Consequences of Posttranslational Isomerization of Ser ⁴⁶ in a Calcium Channel Toxin

1994 • 144 citations

Towards a Phylogeny of Entelegyne Spiders (Araneae, Araneomorphae, Entelegynae)

1999 • 127 citations

Omega-agatoxins: novel calcium channel antagonists of two subtypes from funnel web spider (Agelenopsis aperta) venom.

1990 • 125 citations

Two classes of channel-specific toxins from funnel web spider venom

1989 • 108 citations

Isolation and Characterization of a Peptide Isomerase from Funnel Web Spider Venom

1995 • 100 citations

Toxityping rat brain calcium channels with .omega.-toxins from spider and cone snail venoms

1993 • 99 citations

Inhibition of N- and L-type Ca2+ channels by the spider venom toxin omega-Aga-IIIA.

1991 • 98 citations

Isolation, structure elucidation, and synthesis of novel hydroxylamine-containing polyamines from the venom of the Agelenopsis aperta spider

1990 • 96 citations

A Hot Spot for the Interaction of Gating Modifier Toxins with Voltage-Dependent Ion Channels

2000 • 96 citations

Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists.

1992 • 93 citations

Posttranslational amino acid epimerization: enzyme-catalyzed isomerization of amino acid residues in peptide chains.

1996 • 89 citations

Interactions among Toxins That Inhibit N-type and P-type Calcium Channels

2002 • 89 citations

Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta.

1990 • 86 citations

Discovery and Structure of a Potent and Highly Specific Blocker of Insect Calcium Channels

2001 • 85 citations

Alteration of P-type calcium channel gating by the spider toxin omega-Aga-IVA

1997 • 83 citations

Block of Ca channels in rat central neurons by the spider toxin omega- Aga-IIIA

1994 • 82 citations

ω‐Aga‐I: A presynaptic calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta

1989 • 76 citations

Ca²⁺Currents in Central Insect Neurons: Electrophysiological and Pharmacological Properties

1997 • 76 citations

Antagonism of synaptosomal calcium channels by subtypes of omega-agatoxins.

1992 • 74 citations

Three-dimensional Solution Structure of the Calcium Channel Antagonist ω-Agatoxin IVA: Consensus Molecular Folding of Calcium Channel Blockers

1995 • 68 citations

A Novel Peptide from Funnel Web Spider Venom, ω-Aga-TK, Selectively Blocks P-Type Calcium Channels

1993 • 65 citations

Heterodimeric structure of the spider toxin omega-agatoxin IA revealed by precursor analysis and mass spectrometry.

1992 • 60 citations

Properties of Three Baculovirus-Expressing Genes That Encode Insect-Selective Toxins: μ-Aga-IV, As II, and Sh I

1996 • 59 citations

Sequential assignment and structure determination of spider toxin .omega.-Aga-IVB

1993 • 58 citations

Structure of paralytic acylpolyamines from the spider Agelenopsisaperta

1990 • 55 citations

Insecticide action : from molecule to organism

1989 • 52 citations

Mode of action of atracotoxin at central and peripheral synapses of insects

2003 • 50 citations

Novel insecticidal peptides fromTegenaria agrestis spider venom may have a direct effect on the insect central nervous system

1998 • 47 citations

Aspartate and glutamate as possible transmitters at the ?slow? and ?fast? neuromuscular junctions of the body wall muscles ofMusca larvae

1980 • 47 citations

Arylamine toxins from funnel-web spider (Agelenopsis aperta) venom antagonize N-methyl-D-aspartate receptor function in mammalian brain.

1991 • 45 citations

Type III .omega.-Agatoxins: A Family of Probes for Similar Binding Sites on L- and N-Type Calcium Channels

1994 • 45 citations

The solution structure of ?-Aga-IVB, a P-type calcium channel antagonist from venom of the funnel web spider, Agelenopsis aperta

1995 • 44 citations

Differential antagonism of transmitter release by subtypes of omega-agatoxins

1991 • 42 citations

Calcium Channel Pharmacology

2004 • 40 citations

Novel quaternary ammonium salt-containing polyamines from the Agelenopsis aperta funnel-web spider

1992 • 39 citations

Calcium Channel Pharmacology

2012 • 38 citations

Disulfide Bond Assignment of .omega.-Agatoxins IVB and IVC: Discovery of a D-Serine Residue in .omega.-Agatoxin IVB

1994 • 32 citations

High affinity block of myocardial L-type calcium channels by the spider toxin omega-Aga-toxin IIIA: advantages over 1,4-dihydropyridines.

1992 • 29 citations

Long-term potentiation in the presence of NMDA receptor antagonist arylalkylamine spider toxins

2000 • 26 citations

The Spider Toxin ω-Aga IIIA Defines a High Affinity Site on Neuronal High Voltage-activated Calcium Channels

2000 • 26 citations

Presence of proteins and glutamate as major constituents of the venom of the spider Araneus gemma

1987 • 24 citations

ACYLPOLYAMINES: MASS SPECTROMETRIC ANALYTICAL METHODS FORAraneidaeSPIDER ACYLPOLYAMINES

2000 • 23 citations

Arylamine spider toxins antagonize NMDA receptor‐mediated synaptic transmission in rat hippocampal slices

1991 • 23 citations

Location of the Polyamine Binding Site in the Vestibule of the Nicotinic Acetylcholine Receptor Ion Channel

2001 • 22 citations

The Acylpolyamines from the Venom of the SpiderAgelenopsis aperta

2001 • 22 citations

Anticonvulsant action of an arylamine-containing fraction fromAgelenopsis spider venom

1990 • 21 citations

Omega AGA toxin IVA blocks high-voltage-activated calcium channel currents in cultured pars intercerebralis neurosecretory cells of adult locusta migratoria

1994 • 19 citations

Isolation of myocardial L-type calcium channel gating currents with the spider toxin omega-Aga-IIIA.

1994 • 19 citations

Antagonism of Insect Muscle Glutamate Receptors — with Particular Reference to Arthropod Toxins

1989 • 17 citations

The action of tetrodotoxin on the cockroach, Periplaneta americana: a toxicological and neurophysiological study

1978 • 11 citations

Synaptic Toxins from Arachnid Venoms: Probes for New Insecticide Targets

1989 • 5 citations

Probing Calcium Channels with Venom Toxins

1992 • 3 citations

Deleted Work

1955 • 0 citations