Clockwise Domain Arrangement of the Sodium Channel Revealed by ¼-Conotoxin (GIIIA) Docking Orientation

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Structure and Function of Voltage-Sensitive Ion Channels

1988 • 1,171 citations

Primary structure and functional expression of a mammalian skeletal muscle sodium channel

1989 • 561 citations

Energetics of protein-protein interactions: Analysis ofthe Barnase-Barstar interface by single mutations and double mutant cycles

1995 • 559 citations

Diversity of Conus Neuropeptides

1990 • 537 citations

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

1991 • 460 citations

Conus geographus toxins that discriminate between neuronal and muscle sodium channels.

1985 • 402 citations

A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties

1992 • 387 citations

Mutant Potassium Channels with Altered Binding of Charybdotoxin, a Pore-Blocking Peptide Inhibitor

1989 • 351 citations

Structure and function of voltage‐gated sodium channels

1998 • 349 citations

The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition

1994 • 286 citations

Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels

1992 • 281 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

PEPTIDE TOXINS FROM VENOMOUS CONUS SNAILS

1988 • 234 citations

Agitoxin Footprinting the Shaker Potassium Channel Pore

1996 • 152 citations

Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.

1986 • 151 citations

Molecular basis for pharmacological differences between brain and cardiac sodium channels

1992 • 111 citations

Structure of the sodium channel pore revealed by serial cysteine mutagenesis.

1996 • 111 citations

Active site of mu-conotoxin GIIIA, a peptide blocker of muscle sodium channels.

1991 • 108 citations

Depth Asymmetries of the Pore-Lining Segments of the Na+ Channel Revealed by Cysteine Mutagenesis

1996 • 107 citations

Action of derivatives of .mu.-conotoxin GIIIA on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates

1992 • 104 citations

A mu-conotoxin-insensitive Na+ channel mutant: possible localization of a binding site at the outer vestibule

1995 • 100 citations

Three-Dimensional Solution Structure of μ-Conotoxin GIIIB, a Specific Blocker of Skeletal Muscle Sodium Channels^,

1996 • 92 citations

μ-Conotoxin Giiia Interactions with the Voltage-Gated Na+ Channel Predict a Clockwise Arrangement of the Domains

2000 • 90 citations

Predominant Interactions between μ-Conotoxin Arg-13 and the Skeletal Muscle Na⁺Channel Localized by Mutant Cycle Analysis

1998 • 87 citations

Structure-activity relationships of .mu.-conotoxin GIIIA: structure determination of active and inactive sodium channel blocker peptides by NMR and simulated annealing calculations

1992 • 84 citations

Chimeric study of sodium channels from rat skeletal and cardiac muscle

1992 • 78 citations

Tertiary structure of conotoxin GIIIA in aqueous solution

1991 • 78 citations

Adjacent pore-lining residues within sodium channels identified by paired cysteine mutagenesis.

1996 • 55 citations

The ?I skeletal muscle sodium channel: Mutation E403Q eliminates sensitivity to tetrodotoxin but not to ?-conotoxins GIIIA and GIIIB

1994 • 53 citations

Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis

1997 • 53 citations

Isolation and amino acid compositions of geographutoxin I and II from the marine snailConus geographus Linné

1983 • 53 citations

Extrapore Residues of the S5-S6 Loop of Domain 2 of the Voltage-Gated Skeletal Muscle Sodium Channel (rSkM1) Contribute to the μ-Conotoxin GIIIA Binding Site

1998 • 53 citations

Characterizing the mu-conotoxin binding site on voltage-sensitive sodium channels with toxin analogs and channel mutations.

1995 • 44 citations

Disulfide pairings in geographutoxin I, a peptide neurotoxin from Conus geographus

1990 • 34 citations

Charged Residues between the Selectivity Filter and S6 Segments Contribute to the Permeation Phenotype of the Sodium Channel

1999 • 33 citations

Novel Structural Determinants of μ-Conotoxin (GIIIB) Block in Rat Skeletal Muscle (μ1) Na+ Channels

2000 • 31 citations

Pore residues critical for mu-CTX binding to rat skeletal muscle Na+ channels revealed by cysteine mutagenesis

1997 • 31 citations

[30] Pore-blocking toxins as probes of voltage-dependent channels

1999 • 26 citations

Blockade of [3H]lysine-tetrodotoxin binding to sodium channel proteins by conotoxin GIII

1986 • 26 citations