Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The mutational spectrum of single base-pair substitutions in mRNA splice junctions of human genes: Causes and consequences

1992 • 1,338 citations

Circular transcripts of the testis-determining gene Sry in adult mouse testis

1993 • 1,034 citations

Improved predictions of secondary structures for RNA.

1989 • 822 citations

Exon definition may facilitate splice site selection in RNAs with multiple exons.

1990 • 726 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

A survey on intron and exon lengths

1988 • 569 citations

Expression of Sry, the mouse sex determining gene

1995 • 559 citations

DMSO-enhanced whole cell yeast transformation

1991 • 534 citations

Construction of a novel database containing aberrant splicing mutations of mammalian genes

1994 • 293 citations

Alternative splicing caused by RNA secondary structure

1985 • 274 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Exon Definition May Facilitate Splice Site Selection in RNAs with Multiple Exons

1990 • 269 citations

Stabilization and ribosome association of unspliced pre-mRNAs in a yeast upf1- mutant.

1993 • 265 citations

DNA sequence insertion and evolutionary variation in gene regulation.

1996 • 251 citations

Effect of 5' splice site mutations on splicing of the preceding intron.

1990 • 200 citations

Meiosis-specific RNA splicing in yeast

1991 • 191 citations

Control of Alternative Splicing by the Differential Binding of U1 Small Nuclear Ribonucleoprotein Particle

1991 • 191 citations

Alu: Structure, Origin, Evolution, Significance, and Function of One-Tenth of Human DNA

1996 • 190 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

Architectural limits on split genes

1996 • 179 citations

Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1.

1993 • 178 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA

1995 • 165 citations

Double-Stranded Regions in Heterogeneous Nuclear RNA from Hela Cells

1972 • 151 citations

Lethal and temperature-sensitive mutations and their suppressors identify an essential structural element in U2 small nuclear RNA.

1990 • 147 citations

Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouse.

1988 • 146 citations

The yeast MATa1 gene contains two introns.

1984 • 134 citations

Amount of RNA secondary structure required to induce an alternative splice.

1987 • 128 citations

Intron Definition in Splicing of Small Drosophila Introns

1994 • 110 citations

The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth.

1989 • 105 citations

The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.

1991 • 97 citations

Splice site choice and splicing efficiency are positively influenced by pre-mRNA intramolecular base pairing in yeast

1993 • 94 citations

Pre‐mRNA secondary structure and the regulation of splicing

1993 • 89 citations

Effect of 5′ Splice Site Mutations on Splicing of the Preceding Intron

1990 • 83 citations

A gene chimaera of SV40 and mouse β-globin is transcribed and properly spliced

1981 • 81 citations

Size and position of intervening sequences are critical for the splicing efficiency of pre-mRNA in the yeastSaccharomyces cerevisiae

1985 • 62 citations

Amount of RNA Secondary Structure Required to Induce an Alternative Splice

1987 • 59 citations

Architecture of Fungal Introns: Implications for Spliceosome Assembly

1987 • 59 citations

RNA structural patterns and splicing: molecular basis for an RNA-based enhancer.

1995 • 55 citations

Biochemical Mechanisms Of Constitutive And Regulated Pre-Messenger RNA Splicing

1991 • 54 citations

Intramolecular structure in yeast introns aids the early steps of in vitro spliceosome assembly.

1996 • 49 citations

Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes.

1987 • 49 citations

Secondary structure of the yeast Saccharomyces cerevisiae pre-U3A snoRNA and its implication for splicing efficiency.

1996 • 49 citations

Yeast ribosomal proteins: XIII.Saccharomyces cerevisiaeYL8A gene, interrupted with two introns, encodes a homolog of mammalian L7

1992 • 33 citations

Molecular and genetic characterization ofSLC1, a putativeSaccharomyces cerevisiae homolog of the metazoan cytoplasmic dynein light chain 1

1996 • 31 citations

A Cluster of Transposon-like Repetitive Sequences in Intron 7 of the Human Dystrophin Gene

1993 • 20 citations

The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins

1995 • 11 citations

The Most Abundant Small Cytoplasmic RNA of Saccharomyces cerevisiae Has an Important Function Required for Normal Cell Growth

1989 • 6 citations