Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron.

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Analysis of gene control signals by DNA fusion and cloning in Escherichia coli

1980 • 2,499 citations

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

1981 • 1,881 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

Yeast mRNA splicing in vitro.

1985 • 337 citations

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing

1983 • 239 citations

Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

1985 • 236 citations

Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome.

1986 • 215 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

The effect of temperature-sensitive RNA mutants on the transcription products from cloned ribosomal protein genes of yeast

1981 • 206 citations

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1985 • 194 citations

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

1985 • 184 citations

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

1985 • 172 citations

In vivo characterization of yeast mRNA processing intermediates

1984 • 152 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Specific small nuclear RNAs are associated with yeast spliceosomes

1986 • 127 citations

Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing

1985 • 122 citations

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

1985 • 115 citations

The RNA lariat: A new ring to the splicing of mRNA precursors

1984 • 113 citations

RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.

1986 • 80 citations

Fractionation and characterization of a yeast mRNA splicing extract.

1986 • 73 citations

Expression of the Herpes simplex virus thymidine kinase gene in Saccharomyces cerevisiae

1981 • 71 citations

Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product.

1985 • 65 citations

Size and position of intervening sequences are critical for the splicing efficiency of pre-mRNA in the yeastSaccharomyces cerevisiae

1985 • 62 citations

Construction of a yeast actin gene intron deletion mutant that is defective in splicing and leads to the accumulation of precursor RNA in transformed yeast cells.

1982 • 58 citations

Yeast pre-messenger RNA splicing efficiency depends on critical spacing requirements between the branch point and 3′ splice site.

1986 • 53 citations

Alternative branch points are selected during splicing of a yeast pre-mRNA in mammalian and yeast extracts.

1986 • 48 citations

High frequency recombination and the expression of genes cloned on chimeric yeast plasmids: Identification of a fragment of 2-?m circle essential for transformation

1980 • 46 citations

Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron.

1986 • 29 citations

Deleted Work

1955 • 0 citations