RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

The "Spliceosome": Yeast Pre-Messenger RNA Associates with a 40 S Complex in a Splicing-Dependent Reaction

1985 • 421 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

Yeast mRNA splicing in vitro.

1985 • 337 citations

An RNA Processing Activity That Debranches RNA Lariats

1985 • 300 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing

1983 • 239 citations

Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants

1985 • 236 citations

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene

1983 • 235 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

mRNA splicing efficiency in yeast and the contribution of nonconserved sequences

1985 • 194 citations

Expression of a beta-galactosidase gene containing the ribosomal protein 51 intron is sensitive to the rna2 mutation of yeast.

1983 • 180 citations

Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro

1985 • 172 citations

Chapter 4 Preparation of RNA and Ribosomes from Yeast

1975 • 171 citations

In vivo characterization of yeast mRNA processing intermediates

1984 • 152 citations

Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing

1986 • 150 citations

A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation

1985 • 129 citations

Polyadenylylated nuclear RNA contains branches

1983 • 120 citations

A quantitative analysis of the effects of 5′ junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing

1985 • 115 citations

Behavior of indivdual maternal pA+ RNAs during embryogenesis of Xenopus laevis

1982 • 88 citations

Identification of a sequence responsible for periodic synthesis of yeast histone 2A mRNA.

1982 • 83 citations

Alternative branch points are selected during splicing of a yeast pre-mRNA in mammalian and yeast extracts.

1986 • 48 citations