Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

Free radicals and antioxidants in normal physiological functions and human disease

2006 • 13,251 citations

An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow

1999 • 2,950 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins

2000 • 1,129 citations

Rheumatoid Arthritis

1996 • 960 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

2006 • 824 citations

[2] Preparation and characterization of the different types of collagen

1982 • 758 citations

Disulfide bonds as switches for protein function

2003 • 577 citations

Oxidation in rheumatoid arthritis.

2004 • 542 citations

Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns

1998 • 520 citations

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

2004 • 441 citations

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

2002 • 381 citations

Chronic granulomatous disease

2003 • 377 citations

Antigen-presenting dendritic cells provide the reducing extracellular microenvironment required for T lymphocyte activation

2002 • 365 citations

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

2004 • 346 citations

Generation and Function of Reactive Oxygen Species in Dendritic Cells During Antigen Presentation

2003 • 246 citations

T cell surface redox levels determine T cell reactivity and arthritis susceptibility

2006 • 235 citations

Thiol–Disulfide Balance: From the Concept of Oxidative Stress to that of Redox Regulation

2005 • 235 citations

T cell recognition of carbohydrates on type II collagen.

1994 • 206 citations

Vaccination against IL‐17 suppresses autoimmune arthritis and encephalomyelitis

2006 • 197 citations

Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine

1990 • 184 citations

Regulation of Signal Transduction Through Protein Cysteine Oxidation

2006 • 160 citations

An absence of reactive oxygen species improves the resolution of lung influenza infection

2006 • 158 citations

Hydrogen peroxide generated extracellularly by receptor–ligand interaction facilitates cell signaling

2005 • 152 citations

Lymphocyte surface thiol levels

2003 • 148 citations

A New Arthritis Therapy with Oxidative Burst Inducers

2006 • 145 citations

Displacement of Linker for Activation of T Cells from the Plasma Membrane Due to Redox Balance Alterations Results in Hyporesponsiveness of Synovial Fluid T Lymphocytes in Rheumatoid Arthritis

2000 • 139 citations

A crucial role for macrophages in the pathology of K/B × N serum‐induced arthritis

2005 • 132 citations

Efficient promotion of collagen antibody induced arthritis (CAIA) using four monoclonal antibodies specific for the major epitopes recognized in both collagen induced arthritis and rheumatoid arthritis

2005 • 130 citations

Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics

2003 • 127 citations

Oxidative Stress Promotes Polarization of Human T Cell Differentiation Toward a T Helper 2 Phenotype

2006 • 124 citations

Analysis of type II collagen‐reactive T cells in the mouse I. Different regulation of autoreactive vs. non‐autoreactive anti‐type II collagen T cells in the DBA/1 mouse

1990 • 115 citations

HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death

2005 • 103 citations

Signaling by the Respiratory Burst in Macrophages

2001 • 101 citations

P47phox-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and dbl+

2000 • 100 citations

The use of human CD68 transcriptional regulatory sequences to direct high‐level expression of class A scavenger receptor in macrophages in vitro and in vivo

2001 • 95 citations

IFN-γ and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension

2002 • 93 citations

Effect of Redox Balance Alterations on Cellular Localization of LAT and Downstream T-Cell Receptor Signaling Pathways

2002 • 93 citations

Role of Disulfide Bonds in Regulating Antigen Processing and Epitope Selection

2002 • 78 citations

Intracellular free radical production in synovial T lymphocytes from patients with rheumatoid arthritis

2005 • 77 citations

The extracellular microenvironment plays a key role in regulating the redox status of cell surface proteins in HIV-infected subjects

2004 • 77 citations

NADPH Oxidase Restrains the Matrix Metalloproteinase Activity of Macrophages

2005 • 64 citations

Review

2003 • 57 citations

Analysis of Type II Collagen Reactive T Cells in the Mouse

1991 • 50 citations

In the Absence of Reactive Oxygen Species, T Cells Default to a Th1 Phenotype and Mediate Protection against Pulmonary Cryptococcus neoformans Infection

2006 • 45 citations

Earlier onset of neutrophil-mediated inflammation in the ultraviolet-exposed skin of mice deficient in myeloperoxidase and NADPH oxidase

2006 • 40 citations

Redox Equilibrium in Mucosal T Cells Tunes the Intestinal TCR Signaling Threshold

2005 • 33 citations

[21] Linker for activation of T cells: Sensing redox imbalance

2002 • 9 citations

Genetics of Autoimmune Diseases: A Multistep Process

2006 • 9 citations