The extracellular microenvironment plays a key role in regulating the redox status of cell surface proteins in HIV-infected subjects

GLUTATHIONE

1983 • 5,487 citations

The changing faces of glutathione, a cellular protagonist

2003 • 1,305 citations

REDOX REGULATION OF CELLULAR ACTIVATION

1997 • 1,121 citations

Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.

1990 • 960 citations

Glutathione deficiency is associated with impaired survival in HIV disease

1997 • 665 citations

Glutaredoxins: Glutathione-Dependent Redox Enzymes with Functions Far Beyond a Simple Thioredoxin Backup System

2004 • 643 citations

A new selenoprotein from human lung adenocarcinoma cells: purification, properties, and thioredoxin reductase activity.

1996 • 540 citations

Gene expression and the thiol redox state

1999 • 511 citations

Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene.

1996 • 471 citations

Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.

1990 • 381 citations

The redox protein thioredoxin-1 (Trx-1) increases hypoxia-inducible factor 1alpha protein expression: Trx-1 overexpression results in increased vascular endothelial growth factor production and enhanced tumor angiogenesis.

2002 • 343 citations

Thioredoxin, a Redox Enzyme Released in Infection and Inflammation, Is a Unique Chemoattractant for Neutrophils, Monocytes, and T Cells

1999 • 340 citations

Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae

2003 • 312 citations

N‐acetylcysteine replenishes glutathione in HIV infection

2000 • 275 citations

Redox signalling and the control of cell growth and death

1995 • 256 citations

The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation.

2003 • 248 citations

Elevation of plasma thioredoxin levels in HIV-infected individuals

1996 • 209 citations

Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane

1995 • 190 citations

Sustained integrin ligation involves extracellular free sulfhydryls and enzymatically catalyzed disulfide exchange

2002 • 184 citations

Redox Control of Exofacial Protein Thiols/Disulfides by Protein Disulfide Isomerase

1999 • 178 citations

Thioredoxin as a potent costimulus of cytokine expression.

1996 • 166 citations

Thioltransferase (Glutaredoxin) Is Detected Within HIV-1 and Can Regulate the Activity of Glutathionylated HIV-1 Protease in Vitro

1997 • 164 citations

S-thiolation of glyceraldehyde-3-phosphate dehydrogenase induced by the phagocytosis-associated respiratory burst in blood monocytes.

1994 • 158 citations

Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin α2β1

2003 • 156 citations

Redox modulation of cell surface protein thiols in U937 lymphoma cells: the role of γ-glutamyl transpeptidase-dependent H2O2 production and S-thiolation

1999 • 155 citations

Lymphocyte surface thiol levels

2003 • 148 citations

CD4 and CD8 T cells with high intracellular glutathione levels are selectively lost as the HIV infection progresses

1991 • 145 citations

Protein disulfide isomerase mediates integrin‐dependent adhesion

2000 • 140 citations

Protein disulphide isomerase mediates platelet aggregation and secretion

1999 • 135 citations

Physical Proximity and Functional Association of Glycoprotein 1bα and Protein-disulfide Isomerase on the Platelet Plasma Membrane

2000 • 127 citations

Redox regulation of surface protein thiols: Identification of integrin α-4 as a molecular target by using redox proteomics

2003 • 127 citations

Redox Signaling and the Control of Cell Growth and Death

1996 • 120 citations

Increase in hepatic mixed disulphide and glutathione disulphide levels elicited by paraquat

1982 • 118 citations

Antioxidants Inhibit Stimulation of HIV Transcription

1993 • 114 citations

Sulfhydryl Regulation of L-Selectin Shedding: Phenylarsine Oxide Promotes Activation-Independent L-Selectin Shedding from Leukocytes

2000 • 107 citations

A CD4⁺ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin

1995 • 105 citations

Extracellular glutathione and γ-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone

1993 • 98 citations

Regulation of Protein S-Thiolation by Glutaredoxin 5 in the Yeast Saccharomyces cerevisiae

2002 • 93 citations

Protein Disulfide Isomerase, a Component of the Estrogen Receptor Complex, Is Associated withChlamydia trachomatisSerovar E Attached to Human Endometrial Epithelial Cells

2002 • 93 citations

Membrane-bound proteindisulfide isomerase (PDI) is involved in regulation of surface expression of thiols and drug sensitivity of B-CLL cells.

1997 • 85 citations

N-Acetylcysteine Inhibits Latent HIV Expression in Chronically Infected Cells

1991 • 75 citations

Correlation of clinical data with proteomics profiles in 24 patients with B‐cell chronic lymphocytic leukemia

2001 • 72 citations

Membrane gamma-glutamyl transpeptidase activity of melanoma cells: effects on cellular H2O2 production, cell surface protein thiol oxidation and NF-κB activation status

2000 • 71 citations

Thioredoxin prolongs survival of B-type chronic lymphocytic leukemia cells

2000 • 70 citations

Transfection with γ-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione

1992 • 61 citations

HIV-2 protease is inactivated after oxidation at the dimer interface and activity can be partly restored with methionine sulphoxide reductase

2000 • 60 citations

Reversible Oxidative Modification as a Mechanism for Regulating Retroviral Protease Dimerization and Activation

2003 • 49 citations

Redox Control on the Cell Surface: Implications for HIV-1 Entry

2003 • 44 citations

Thiol‐Proteindisulfide–Oxidoreductase (Proteindisulfide Isomerase): a New Plasma Membrane Constituent of Mature Human B Lymphocytes

1994 • 42 citations

Conserved Cysteines of the Human Immunodeficiency Virus Type 1 Protease Are Involved in Regulation of Polyprotein Processing and Viral Maturation of Immature Virions

1999 • 41 citations

[24] Reversible oxidation of HIV-2 protease

2002 • 16 citations