Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

Preparation of PCR-Quality Mouse Genomic DNA with Hot Sodium Hydroxide and Tris (HotSHOT)

2000 • 1,567 citations

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

2003 • 1,143 citations

Phagocytes and oxidative stress

2000 • 1,055 citations

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

2000 • 869 citations

Finding Genes That Underlie Complex Traits

2002 • 866 citations

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

2003 • 822 citations

Hydrogen peroxide as second messenger in lymphocyte activation

2002 • 760 citations

An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis

2003 • 616 citations

The p47phox mouse knock-out model of chronic granulomatous disease.

1995 • 487 citations

Positional identification of Ncf1 as a gene that regulates arthritis severity in rats

2002 • 381 citations

CARTILAGE OLIGOMERIC MATRIX PROTEIN: A NOVEL MARKER OF CARTILAGE TURNOVER DETECTABLE IN SYNOVIAL FLUID AND BLOOD

1992 • 342 citations

B cell-deficient mice do not develop type II collagen-induced arthritis (CIA)

1998 • 320 citations

Collagen Type II-Specific Monoclonal Antibody-Induced Arthritis in Mice

2003 • 280 citations

Nature of the collagen synthesized by a transplanted chondrosarcoma

1975 • 248 citations

Generation and Function of Reactive Oxygen Species in Dendritic Cells During Antigen Presentation

2003 • 246 citations

Screening the genome for rheumatoid arthritis susceptibility genes: A replication study and combined analysis of 512 multicase families

2003 • 241 citations

Timing of Pregnancy in Relation to the Onset of Rheumatoid Arthritis

1992 • 239 citations

Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.

1996 • 220 citations

Reactive oxygen species activate human peripheral blood dendritic cells

1999 • 201 citations

Homologous type II collagen induces chronic and progressive arthritis in mice

1986 • 196 citations

Epitope‐specific recognition of type II collagen by rheumatoid arthritis antibodies is shared with recognition by antibodies that are arthritogenic in collagen‐induced arthritis in the mouse

2002 • 174 citations

Expression of a transgenic class II Ab gene confers susceptibility to collagen‐induced arthritis

1994 • 160 citations

Lymphocyte surface thiol levels

2003 • 148 citations

Breast-feeding and postpartum relapse in women with rheumatoid and inflammatory arthritis

2000 • 123 citations

Evidence for Common Autoimmune Disease Genes Controlling Onset, Severity, and Chronicity Based on Experimental Models for Multiple Sclerosis and Rheumatoid Arthritis

2000 • 115 citations

P47phox-deficient NADPH oxidase defect in neutrophils of diabetic mouse strains, C57BL/6J-m db/db and dbl+

2000 • 100 citations

Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis Models

2003 • 93 citations

Superoxide Prevents Nitric Oxide-Mediated Suppression of Helper T Lymphocytes: Decreased Autoimmune Encephalomyelitis in Nicotinamide Adenine Dinucleotide Phosphate Oxidase Knockout Mice

2000 • 93 citations

Effect of Redox Balance Alterations on Cellular Localization of LAT and Downstream T-Cell Receptor Signaling Pathways

2002 • 93 citations

Maintained pregnancy levels of oestrogen afford complete protection from post-partum exacerbation of collagen-induced arthritis

1991 • 88 citations

Autosomal recessive chronic granulomatous disease caused by defects in NCF-1, the gene encoding the phagocyte p47-phox: mutations not arising in theNCF-1 pseudogenes

2001 • 84 citations

Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis.

1996 • 80 citations

Functional modules and expression of mouse p40 ^phox and p67^phox, SH3‐domain‐containing proteins involved in the phagocyte NADPH oxidase complex

1998 • 77 citations

Screening of several H-2 congenic mouse strains identified H-2q mice as highly susceptible to MOG-induced EAE with minimal adjuvant requirement

2000 • 73 citations

Comment on "The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease"

2003 • 69 citations

Enhancement of collagen-induced arthritis in female mice by estrogen receptor blockage

2001 • 68 citations

Effect of pregnancy on collagen-induced arthritis in mice.

1987 • 66 citations

IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis

2002 • 51 citations

Investigation of susceptibility loci identified in the UK rheumatoid arthritis whole‐genome scan in a further series of 217 UK affected sibling pairs

2004 • 45 citations

Characterization of the Superoxide-Generating System in Human Peripheral Lymphocytes and Lymphoid Cell Lines1

1995 • 39 citations

Relationship between oxidative burst activity and CD11b expression in neutrophils and monocytes from healthy individuals: Effects of race and gender

2001 • 38 citations

Enhanced Susceptibility to Lupus Contributed from the Nonautoimmune C57BL/10, But Not C57BL/6, Genome

2000 • 29 citations