T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

NOX enzymes and the biology of reactive oxygen

2004 • 2,940 citations

NAD(P)H Oxidase

2000 • 2,902 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

NADPH Oxidase: An Update

1999 • 2,134 citations

Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation

1995 • 1,549 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Epidermal Growth Factor (EGF)-induced Generation of Hydrogen Peroxide

1997 • 1,208 citations

Mouse model of X–linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production

1995 • 920 citations

Fas and Fas ligand: lpr and gld mutations

1995 • 906 citations

Genetic, Biochemical, and Clinical Features of Chronic Granulomatous Disease

2000 • 869 citations

Novel gp91 ^phox Homologues in Vascular Smooth Muscle Cells

2001 • 841 citations

Angiotensin II Stimulation of NAD(P)H Oxidase Activity

2002 • 719 citations

A Ca2+-activated NADPH Oxidase in Testis, Spleen, and Lymph Nodes

2001 • 598 citations

Reactive Oxygen Species Mediate the Activation of Akt/Protein Kinase B by Angiotensin II in Vascular Smooth Muscle Cells

1999 • 563 citations

Pivotal Role of a gp91 ^phox -Containing NADPH Oxidase in Angiotensin II-Induced Cardiac Hypertrophy in Mice

2002 • 524 citations

The NAD(P)H Oxidase Homolog Nox4 Modulates Insulin-Stimulated Generation of H₂O₂ and Plays an Integral Role in Insulin Signal Transduction

2004 • 506 citations

Reactive Oxygen Species Mediate Cytokine Activation of c-Jun NH2-terminal Kinases

1996 • 491 citations

Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense

2003 • 490 citations

Regulation of reactive-oxygen-species generation in fibroblasts by Rac 1

1996 • 488 citations

The p47phox mouse knock-out model of chronic granulomatous disease.

1995 • 487 citations

Two Novel Proteins Activate Superoxide Generation by the NADPH Oxidase NOX1

2003 • 477 citations

Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation

2002 • 447 citations

Activation of an H2O2-generating NADH Oxidase in Human Lung Fibroblasts by Transforming Growth Factor β1

1995 • 426 citations

Intracellular Localization and Preassembly of the NADPH Oxidase Complex in Cultured Endothelial Cells

2002 • 393 citations

Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells

1999 • 385 citations

Recombinant 47-Kilodalton Cytosol Factor Restores NADPH Oxidase in Chronic Granulomatous Disease

1989 • 341 citations

Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles

1999 • 302 citations

Molecular Determinants of Selectivity in 5-Hydroxytryptamine1B Receptor-G Protein Interactions

1997 • 277 citations

Human fat cells possess a plasma membrane-bound H2O2-generating system that is activated by insulin via a mechanism bypassing the receptor kinase.

1992 • 232 citations

PKCζ Regulates TNF-α–Induced Activation of NADPH Oxidase in Endothelial Cells

2002 • 220 citations

Bcl-2 and Mitochondrial Oxygen Radicals

1999 • 178 citations

T Cell Receptor Stimulation, Reactive Oxygen Species, and Cell Signaling

2004 • 167 citations

Structure-Function Relationship of Lipoprotein Lipase-mediated Enhancement of Very Low Density Lipoprotein Binding and Catabolism by the Low Density Lipoprotein Receptor

1996 • 153 citations

Rapid and specific reactive oxygen species generation via NADPH oxidase activation during Fas‐mediated apoptosis

1998 • 148 citations

Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells

2003 • 143 citations

Superoxide-dependent nitroblue tetrazolium reduction and expression of cytochrome b-245 components by human tonsillar B lymphocytes and B cell lines.

1989 • 140 citations

Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion

1999 • 139 citations

Evaluation of flow cytometric methods for diagnosis of chronic granulomatous disease variants under routine laboratory conditions

1994 • 98 citations

Release of preformed Fas ligand in soluble form is the major factor for activation‐induced death of Jurkat T cells

1996 • 94 citations

Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase

2000 • 87 citations

Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes

1998 • 81 citations

Role of reactive oxygen intermediates in TCR-induced death of T cell blasts and hybridomas.

1996 • 80 citations

T cell receptor-stimulated generation of hydrogen peroxide inhibits MEK-ERK activation and lck serine phosphorylation

2003 • 79 citations

Location of the Epitope for 7D5, a Monoclonal Antibody Raised against Human Flavocytochrome b₅₅₈, to the Extracellular Peptide Portion of Primate gp91^phox

2001 • 74 citations

The stimulus-sensitive H2O2-generating system present in human fat-cell plasma membranes is multireceptor-linked and under antagonistic control by hormones and cytokines

1995 • 73 citations

Role of TNF Receptor-Associated Factor 3 in the CD40 Signaling by Production of Reactive Oxygen Species through Association with p40phox, a Cytosolic Subunit of Nicotinamide Adenine Dinucleotide Phosphate Oxidase

2004 • 56 citations

The intracellular oxidation of 2′,7′-dichlorofluorescin in murine T lymphocytes

2001 • 48 citations

A 29-kDa Protein Associated with p67 Expresses Both Peroxiredoxin and Phospholipase A2 Activity and Enhances Superoxide Anion Production by a Cell-free System of NADPH Oxidase Activity

2002 • 47 citations

Dual mechanism of Fas-induced cell death in neuroglioma cells: a role for reactive oxygen species

1999 • 44 citations

NADPH Oxidase Activity and Cytochromeb558Content of Human Epstein-Barr-Virus-Transformed B Lymphocytes Correlate with Expression of Genes Encoding Components of the Oxidase System

1998 • 40 citations

The p47 ^{phox −/−} Mouse Model of Chronic Granulomatous Disease Has Normal Granuloma Formation and Cytokine Responses to Mycobacterium avium and Schistosoma mansoni Eggs

1999 • 34 citations

Relationships of p40phox with p67phox in the Activation and Expression of the Human Respiratory Burst NADPH Oxidase

2000 • 25 citations

Exuberant Inflammation in Nicotinamide Adenine Dinucleotide Phosphate-Oxidase-Deficient Mice After Allogeneic Marrow Transplantation

2002 • 19 citations

Identification of a splice variant mRNA of p40phox, an NADPH oxidase component of phagocytes¹

1999 • 14 citations