HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

Mdm2 promotes the rapid degradation of p53

1997 • 4,336 citations

Regulation of p53 stability by Mdm2

1997 • 3,238 citations

Live or let die: the cell's response to p53

2002 • 3,138 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 • 2,784 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1997 • 1,906 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1996 • 1,457 citations

The p53 pathway

1999 • 1,322 citations

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

2003 • 1,298 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

The IARC TP53 database: New online mutation analysis and recommendations to users

2002 • 1,248 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

Post‐translational modifications and activation of p53 by genotoxic stresses

2001 • 1,076 citations

A role for ATR in the DNA damage-induced phosphorylation of p53

1999 • 1,043 citations

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

2003 • 862 citations

A new method to detect apoptosis in paraffin sections: in situ end-labeling of fragmented DNA.

1993 • 823 citations

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

2002 • 789 citations

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells.

1996 • 738 citations

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

2003 • 735 citations

Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation

2003 • 708 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

The ubiquitin ligase COP1 is a critical negative regulator of p53

2004 • 693 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor

2005 • 529 citations

Acetylation of p53 Inhibits Its Ubiquitination by Mdm2

2002 • 478 citations

Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling

2006 • 468 citations

Induction of apoptosis by Drosophila reaper, hid and grim through inhibition of IAP function

2000 • 448 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Identity between TRAP and SMCC Complexes Indicates Novel Pathways for the Function of Nuclear Receptors and Diverse Mammalian Activators

1999 • 421 citations

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

2004 • 406 citations

MDM2, an introduction.

2003 • 387 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

In Vivo Mitochondrial p53 Translocation Triggers a Rapid First Wave of Cell Death in Response to DNA Damage That Can Precede p53 Target Gene Activation

2004 • 368 citations

Latent and active p53 are identical in conformation.

2001 • 268 citations

A New Cluster of Genes Within the Human Major Histocompatibility Complex

1989 • 247 citations

Functional Analysis of the Roles of Posttranslational Modifications at the p53 C Terminus in Regulating p53 Stability and Activity

2005 • 232 citations

p53 Linear Diffusion along DNA Requires Its C Terminus

2004 • 184 citations

The C-terminal lysines fine-tune P53 stress responses in a mouse model but are not required for stability control or transactivation

2005 • 181 citations

Generation and Characterization of Smac/DIABLO-Deficient Mice

2002 • 171 citations

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

2002 • 145 citations

A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

1990 • 141 citations

Scythe: a novel reaper-binding apoptotic regulator

1998 • 127 citations

Identifying candidate colon cancer tumor suppressor genes using inhibition of nonsense-mediated mRNA decay in colon cancer cells

2006 • 101 citations

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper

2001 • 100 citations

Apoptosis Induced by Drosophila Reaper and Grim in a Human System

1998 • 93 citations

The Reaper-Binding Protein Scythe Modulates Apoptosis and Proliferation during Mammalian Development

2005 • 88 citations

Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity

1999 • 85 citations

Inhibition of Translation and Induction of Apoptosis by Bunyaviral Nonstructural Proteins Bearing Sequence Similarity to Reaper

2003 • 74 citations

Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3

2004 • 65 citations

Promoter-specific p53-dependent histone acetylation following DNA damage

2004 • 63 citations

Human Scythe Contains a Functional Nuclear Localization Sequence and Remains in the Nucleus during Staurosporine-Induced Apoptosis

2001 • 48 citations

Facilitated search for specific genomic targets by p53 c-terminal basic DNA binding domain

2004 • 39 citations

Enhancement of p53 sequence-specific binding by DNA supercoiling

2004 • 38 citations

Investigations of the supercoil‐selective DNA binding of wild type p53 suggest a novel mechanism for controlling p53 function

2004 • 37 citations

Immediate early gene X-1 interacts with proteins that modulate apoptosis

2004 • 32 citations

Binding to the naturally occurring double p53 binding site of the Mdm2 promoter alleviates the requirement for p53 C-terminal activation

2001 • 24 citations

Insights into Selective Activation of p53 DNA Binding by c-Abl

2005 • 22 citations