Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

2001 • 2,550 citations

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

1997 • 2,510 citations

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

2001 • 2,226 citations

Noxa, a BH3-Only Member of the Bcl-2 Family and Candidate Mediator of p53-Induced Apoptosis

2000 • 2,064 citations

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

2001 • 2,042 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

CBP/p300 in cell growth, transformation, and development

2000 • 1,712 citations

Acetylation of Histones and Transcription-Related Factors

2000 • 1,702 citations

The p53 pathway

1999 • 1,322 citations

The complexity of p53 modulation: emerging patterns from divergent signals

1998 • 1,319 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

2001 • 1,275 citations

DNA damage activates p53 through a phosphorylation–acetylation cascade

1998 • 1,194 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

Acetylation: a regulatory modification to rival phosphorylation?

2000 • 1,136 citations

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

2003 • 1,075 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

Database of p53 gene somatic mutations in human tumors and cell lines.

1994 • 866 citations

Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

2002 • 842 citations

PML regulates p53 acetylation and premature senescence induced by oncogenic Ras

2000 • 826 citations

Deacetylation of p53 modulates its effect on cell growth and apoptosis

2000 • 794 citations

p53

2000 • 785 citations

Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: A molecular model for the formation of heterochromatin in yeast

1995 • 778 citations

p53 Sites Acetylated In Vitro by PCAF and p300 Are Acetylated In Vivo in Response to DNA Damage

1999 • 764 citations

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

2003 • 735 citations

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

2001 • 704 citations

Binding and modulation of p53 by p300/CBP coactivators

1997 • 698 citations

Recruitment of p300/CBP in p53-Dependent Signal Pathways

1997 • 671 citations

Synergistic activation of transcription by CBP and p53

1997 • 599 citations

Functions of the MDM2 oncoprotein

1999 • 556 citations

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2

2001 • 554 citations

PML is induced by oncogenicrasand promotes premature senescence

2000 • 519 citations

Acetylation of p53 Inhibits Its Ubiquitination by Mdm2

2002 • 478 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

2001 • 437 citations

Histone Deacetylases Specifically Down-regulate p53-dependent Gene Activation

2000 • 415 citations

Use of Chromatin Immunoprecipitation To Clone Novel E2F Target Promoters

2001 • 387 citations

Multiple C-Terminal Lysine Residues Target p53 for Ubiquitin-Proteasome-Mediated Degradation

2000 • 383 citations

Control of Smad7 Stability by Competition between Acetylation and Ubiquitination

2002 • 366 citations

Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

1995 • 347 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

2002 • 319 citations

High mobility group protein-1 (HMG-1) is a unique activator of p53

1998 • 316 citations

C-Terminal Ubiquitination of p53 Contributes to Nuclear Export

2001 • 241 citations

Transcriptional activation by p53 correlates with suppression of growth but not transformation

1994 • 237 citations

Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors

2002 • 217 citations

Why Is p53 Acetylated?

2001 • 211 citations

Acetylation of TAFI68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription

2001 • 200 citations

Multiple Lysine Mutations in the C-Terminal Domain of p53 Interfere with MDM2-Dependent Protein Degradation and Ubiquitination

2000 • 194 citations

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

2002 • 145 citations

Signaling to p53: breaking the posttranslational modification code.

2000 • 142 citations

Adenovirus E1B 55-Kilodalton Oncoprotein Inhibits p53 Acetylation by PCAF

2000 • 98 citations

Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export

2001 • 90 citations

Regulation and activation of p53 and its family members

1999 • 89 citations

Genomewide histone acetylation microarrays

2003 • 53 citations

Tying-up tuberculosis

2000 • 4 citations