Ricin Triggers Apoptotic Morphological Changes through Caspase-3 Cleavage of BAT3

Experiments in molecular genetics

1972 • 28,260 citations

The biochemistry of apoptosis

2000 • 7,314 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

1998 • 4,383 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

1998 • 3,603 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Death and anti-death: tumour resistance to apoptosis

2002 • 1,963 citations

Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis

1998 • 1,927 citations

Annexin V-Affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure

1998 • 1,850 citations

Apoptotic Pathways

1998 • 1,193 citations

Genetic Control of Programmed Cell Death in Drosophila

1994 • 1,028 citations

Substrate Specificities of Caspase Family Proteases

1997 • 871 citations

Prevention of Programmed Cell Death of Sympathetic Neurons by the bcl-2 Proto-Oncogene

1992 • 724 citations

Ricin: structure, mode of action, and some current applications

1994 • 469 citations

Different biological properties of the two constituent peptide chains of ricin a toxic protein inhibiting protein synthesis

1973 • 464 citations

Molecular chaperone targeting and regulation by BAG family proteins

2001 • 390 citations

The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.

1988 • 380 citations

Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects

2003 • 266 citations

Vascular leak syndrome: a side effect of immunotherapy

1997 • 260 citations

NEW EMBO MEMBERS' REVIEW: Entry of ricin and Shiga toxin into cells: molecular mechanisms and medical perspectives

2000 • 249 citations

Caspases Disrupt the Nuclear-Cytoplasmic Barrier

2000 • 234 citations

Extranuclear Apoptosis

1999 • 233 citations

Abrin and Ricin: New Anti-tumour Substances

1970 • 185 citations

Pathways followed by ricin and Shiga toxin into cells

2001 • 160 citations

A gene pair from the human major histocompatibility complex encodes large proline-rich proteins with multiple repeated motifs and a single ubiquitin-like domain.

1990 • 141 citations

Nuclear apoptotic changes: An overview

2001 • 140 citations

Damage to nuclear DNA induced by Shiga toxin 1 and ricin in human endothelial cells¹

2002 • 136 citations

Wild-type and mutated presenilins 2 trigger p53-dependent apoptosis and down-regulate presenilin 1 expression in HEK293 human cells and in murine neurons

2002 • 133 citations

A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma.

2002 • 133 citations

Scythe: a novel reaper-binding apoptotic regulator

1998 • 127 citations

Ricin A-Chain and Ricin A-Chain Immunotoxins Rapidly Damage Human Endothelial Cells: Implications for Vascular Leak Syndrome

1993 • 106 citations

Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper

2001 • 100 citations

Involvement of Both Caspase-Like Proteases and Serine Proteases in Apoptotic Cell Death Induced by Ricin, Modeccin, Diphtheria Toxin, and Pseudomonas Toxin

1998 • 96 citations

Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity

1999 • 85 citations

Morphology of ricin and abrin exposed endothelial cells is consistent with apoptotic cell death

1996 • 78 citations

Apoptosis induced by immunotoxins used in the treatment of hematologic malignancies

2000 • 74 citations

The Effect of a Monoclonal Antibody Coupled to Ricin A Chain-Derived Peptides on Endothelial Cells in Vitro: Insights into Toxin-Mediated Vascular Damage

2000 • 74 citations

Human Scythe Contains a Functional Nuclear Localization Sequence and Remains in the Nucleus during Staurosporine-Induced Apoptosis

2001 • 48 citations

The toxicity of deglycosylated ricin A chain-containing immunotoxins in patients with non-Hodgkin's lymphoma is exacerbated by prior radiotherapy: a retrospective analysis of patients in five clinical trials.

2001 • 46 citations

Chemical Construction of Immunotoxins

2001 • 37 citations

An In Vitro Model for Toxin-Mediated Vascular Leak Syndrome: Ricin Toxin A Chain Increases the Permeability of Human Endothelial Cell Monolayers

1997 • 36 citations

An In Vitro Model for Toxin-Mediated Vascular Leak Syndrome: Ricin Toxin A Chain Increases the Permeability of Human Endothelial Cell Monolayers

1997 • 34 citations

Cloning and Characterization of Rat BAT3 cDNA

1999 • 21 citations