Role of eicosanoids in prostate cancer progression.

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 • 2,100 citations

Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potential

1997 • 1,411 citations

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

1990 • 777 citations

The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 • 670 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Over-expression of cyclooxygenase-2 in human prostate adenocarcinoma

2000 • 535 citations

Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells

1998 • 498 citations

NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells.

1998 • 439 citations

Discovery of a second 15 S -lipoxygenase in humans

1997 • 388 citations

15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

2000 • 381 citations

INHIBITION OF CYCLOOXYGENASE-2 SUPPRESSES ANGIOGENESIS AND THE GROWTH OF PROSTATE CANCER IN VIVO

2000 • 361 citations

Arachidonate lipoxygenases as essential regulators of cell survival and apoptosis.

1996 • 341 citations

Expression of cyclooxygenase-2 in prostate carcinoma

2000 • 319 citations

Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.

2000 • 305 citations

Induction of cyclo-oxygenase-2 mRNA by prostaglandin E2 in human prostatic carcinoma cells

1997 • 222 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in the Human Prostate

2006 • 218 citations

Lipoxygenase-5 is overexpressed in prostate adenocarcinoma

2001 • 216 citations

Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines

1999 • 211 citations

15S-Hydroxyeicosatetraenoic acid activates peroxisome proliferator-activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells.

2001 • 209 citations

Prostate cancer risk and consumption of fish oils: A dietary biomarker-based case–control study

1999 • 207 citations

12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

1994 • 202 citations

Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer

1995 • 184 citations

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

1998 • 173 citations

Oxidized LDL reduces monocyte CCR2 expression through pathways involving peroxisome proliferator–activated receptor γ

2000 • 172 citations

Upregulation of vascular endothelial growth factor by cobalt chloride-simulated hypoxia is mediated by persistent induction of cyclooxygenase-2 in a metastatic human prostate cancer cell line.

1999 • 163 citations

Increased expression of cyclooxygenase-2 and nitric oxide synthase-2 in human prostate cancer

2001 • 151 citations

Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886

2001 • 151 citations

15-Lipoxygenase-2 (15-LOX-2) Is Expressed in Benign Prostatic Epithelium and Reduced in Prostate Adenocarcinoma

1999 • 148 citations

Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase

2000 • 134 citations

Overexpression of 15-lipoxygenase-1 in PC-3 human prostate cancer cells increases tumorigenesis

2001 • 133 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)‐HETE‐induced endothelial cell retraction

1989 • 122 citations

Concordant induction of 15-lipoxygenase-1 and mutant p53 expression in human prostate adenocarcinoma: correlation with Gleason staging

2000 • 112 citations

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

1995 • 112 citations

Differential expression of cyclooxygenase-2 and its regulation by tumor necrosis factor-alpha in normal and malignant prostate cells.

2001 • 111 citations

12(S)-HETE Enhancement of Prostate Tumor Cell Invasion: Selective Role of PKC

1994 • 109 citations

Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia.

2001 • 98 citations

5-lipoxygenase inhibitors reduce PC-3 cell proliferation and initiate nonnecrotic cell death

1998 • 97 citations

The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP

1999 • 92 citations

Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice

1998 • 78 citations

5-Lipoxygenase-activating protein (FLAP)

1995 • 73 citations

Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.

1994 • 68 citations

Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.

1994 • 66 citations

Reduced 15-lipoxygenase-2 immunostaining in prostate adenocarcinoma: Correlation with grade and expression in high-grade prostatic intraepithelial neoplasia

2000 • 64 citations

Eicosanoid Activation of Extracellular Signal-regulated Kinase1/2 in Human Epidermoid Carcinoma Cells

2000 • 62 citations

Production of 13-Hydroxyoctadecadienoic Acid (13-HODE) by Prostate Tumors and Cell Lines

1997 • 50 citations

Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12/15-lipoxygenase gene expression: Evidence that 15-lipoxygenase is a mutator gene

1999 • 50 citations

A Relationship between 5-Lipoxygenase-activating Protein and bcl-xL Expression in Murine Pro-B Lymphocytic FL5.12 Cells

1998 • 45 citations

PKC mediates 12(S)‐HETE‐induced cytoskeletal rearrangement in B16A melanoma cells

1993 • 45 citations

Immunomorphological characterization and effects of 12-(s)-hete on a dynamic intracellular pool of the αiibβ3-integrin in melanoma cells

1995 • 37 citations

Differential Secretion of Cathepsins B and L from Normal and Tumor Human Lung Cells Stimulated by 12(S)-Hydroxy-eicosatetraenoic Acid

1996 • 35 citations

Eicosanoid 12(S)-HETE Activates Phosphatidylinositol 3-Kinase

2000 • 33 citations

12-Lipoxygenase in Lewis lung carcinoma cells: Molecular identity, intracellular distribution of activity and protein, and Ca2+-dependent translocation from cytosol to membranes

1995 • 29 citations