Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Angiogenesis.

1992 • 2,581 citations

Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

1994 • 2,293 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis

1998 • 829 citations

Involvement of platelets in tumour angiogenesis?

1998 • 351 citations

Lipoxin formation during human neutrophil-platelet interactions. Evidence for the transformation of leukotriene A4 by platelet 12-lipoxygenase in vitro.

1990 • 297 citations

Platelets and cancer metastasis: A causal relationship?

1992 • 289 citations

Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A₂ in endothelial cells via p42/p44 mitogen‐activated protein kinase

1997 • 258 citations

In vitro release of vascular endothelial growth factor during platelet aggregation

1998 • 225 citations

Regulation of distinct steps of angiogenesis by different angiogenic molecules.

1998 • 208 citations

Elevated 12-lipoxygenase mRNA expression correlates with advanced stage and poor differentiation of human prostate cancer

1995 • 184 citations

The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition.

1987 • 181 citations

Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.

1998 • 173 citations

Platelet number and interleukin-6 correlate with VEGF but not with bFGF serum levels of advanced cancer patients

1999 • 168 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.

1994 • 115 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

12(S)-HETE Is a Mitogenic Factor for Microvascular Endothelial Cells: Its Potential Role in Angiogenesis

1995 • 109 citations

Functional Expression and Cellular Localization of a Mouse Epidermal Lipoxygenase

1996 • 101 citations

A Leukocyte Type of 12-Lipoxygenase Is Expressed in Human Vascular and Mononuclear Cells

1995 • 95 citations

Angiogenin stimulates endothelial cell prostacyclin secretion by activation of phospholipase A2.

1989 • 95 citations

Characterization of human 12-lipoxygenase genes.

1992 • 91 citations

Lipoxin synthase activity of human platelet 12-lipoxygenase

1993 • 86 citations

Basic fibroblast growth factor-stimulated endothelial cell movement is mediated by a pertussis toxin-sensitive pathway regulating phospholipase A2 activity.

1994 • 86 citations

Arachidonic Acid Metabolites in bFGF-, PDGF-, and Serum-Stimulated Vascular Cell Growth

1994 • 83 citations

12‐lipoxygenase isoenzymes in mouse skin tumor development

1995 • 83 citations

Induction of Monocyte Binding to Endothelial Cells by MM-LDL

1999 • 70 citations

12(S)‐hete promotes tumor‐cell adhesion by increasing surface expression of α_Vβ₃ integrins on endothelial cells

1993 • 67 citations

Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.

1994 • 66 citations

Transcriptional activation of endothelial cell integrin αv by protein kinase C activator 12(S)-HETE

1995 • 65 citations

Elevated 12-Lipoxygenase Activity in the Spontaneously Hypertensive Rat

1997 • 64 citations

Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.

1994 • 61 citations

Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor.

1993 • 57 citations

Signal transduction by bFGF, but not TGFβ1, involves arachidonic acid metabolism in endothelial cells

1991 • 53 citations

Platelet-Derived 12-Hydroxyeicosatetraenoic Acid Plays an Important Role in Mediating Canine Coronary Thrombosis by Regulating Platelet Glycoprotein IIb/IIIa Activation

1998 • 51 citations

ISolation and characterization of cerebral resistance vessel endothelium in culture

1993 • 50 citations

Protein‐kinase‐C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization

1992 • 46 citations

Lipoxin generation by human megakaryocyte-induced 12-lipoxygenase

1992 • 45 citations

A quantitative assay using basement membrane extracts to study tumor angiogenesisin vivo

1996 • 44 citations

The role of platelet activating factor and other lipid mediators in inflammatory angiogenesis

1998 • 43 citations

12(S)-HETE-induced microvascular endothelial cell retraction results from PKC-dependent rearrangement of cytoskeletal elements and αVβ3 integrins

1993 • 43 citations

In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability

1999 • 30 citations

Anti‐angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvascular endothelial cells and neovascularization in mice

1993 • 30 citations

Elevated 12-lipoxygenase activity in the spontaneously hypertensive rat*1

1997 • 25 citations

Eicosanoids in sickle cell disease: potential relevance of 12(s)-hydroxy-5,8,10,14-eicosatetraenoic acid to the pathophysiology of vaso-occlusion

1998 • 25 citations

Albumin modifies the metabolism of hydroxyeicosatetraenoic acids via 12-lipoxygenase in human platelets

1999 • 15 citations

Possible involvement of arachidonic acid metabolites in the synergistic action of endothelial mitogenesis by basic fibroblast growth factor and phorbol ester.

1992 • 14 citations

Basic fibroblast growth factor-induced glycosaminoglycan production in cultured vascular endothelial cells results from enhanced protein synthesis mediated by the lipoxygenase pathway

1997 • 3 citations