APP-BP1, a Novel Protein That Binds to the Carboxyl-terminal Region of the Amyloid Precursor Protein

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Focal Adhesions: Transmembrane Junctions Between the Extracellular Matrix and the Cytoskeleton

1988 • 2,137 citations

Eukaryotic proteins expressed in Escherichia coli: An improved thrombin cleavage and purification procedure of fusion proteins with glutathione S-transferase

1991 • 1,779 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

1994 • 1,472 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

pl Bl5: A cDNA Clone of the Rat mRNA Encoding Cyclophilin

1988 • 1,039 citations

Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin

1986 • 854 citations

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties

1992 • 846 citations

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein

1993 • 800 citations

Autophosphorylation sites on the epidermal growth factor receptor

1984 • 730 citations

Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.

1991 • 713 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Growth and development of the axr1 mutants of Arabidopsis.

1990 • 678 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2

1986 • 535 citations

Role of Lymphocyte Adhesion Receptors in Transient Interactions and Cell Locomotion

1991 • 532 citations

Arabidopsis auxin-resistance gene AXR1 encodes a protein related to ubiquitin-activating enzyme E1

1993 • 531 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

1992 • 455 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Identification, transmembrane orientation and biogenesis of the amyloid A4 precursor of Alzheimer's disease.

1988 • 392 citations

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

1993 • 388 citations

Cell adhesion molecules in vertebrate neural development.

1988 • 386 citations

The regulation of amyloid β protein precursor secretion and its modulatory role in cell adhesion

1989 • 355 citations

Behavioral and anatomical deficits in mice homozygous for a modified ?-amyloid precursor protein gene

1994 • 307 citations

Platelet Coagulation Factor XI _a -Inhibitor, a Form of Alzheimer Amyloid Precursor Protein

1990 • 299 citations

UBA 1: an essential yeast gene encoding ubiquitin-activating enzyme.

1991 • 281 citations

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1994 • 278 citations

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene

1992 • 275 citations

Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation.

1985 • 236 citations

Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine.

1986 • 229 citations

Activation-Induced Ubiquitination of the T Cell Antigen Receptor

1992 • 213 citations

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

1994 • 197 citations

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1995 • 196 citations

Amyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein

1988 • 189 citations

Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets.

1992 • 186 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Ligand-induced polyubiquitination of the platelet-derived growth factor beta-receptor.

1992 • 173 citations

Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease

1992 • 161 citations

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain.

1992 • 150 citations

The Amyloid β Protein Gene Is Not Duplicated in Brains from Patients with Alzheimer's Disease

1987 • 139 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion

1992 • 131 citations

Molecular cloning, sequence, and tissue distribution of the human ubiquitin-activating enzyme E1.

1991 • 129 citations

Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.

1993 • 119 citations

Role of amyloid precursor protein (APP): Study with antisense transfection of human neuroblastoma cells

1992 • 99 citations

Role of the β-amyloid precursor protein in Alzheimer's disease

1994 • 95 citations

A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.

1993 • 93 citations

Differential expression of mRNAs for the NGF family of neurotrophic factors in the adult rat central olfactory system

1991 • 92 citations

Association and release of the amyloid protein precursor of Alzheimer's disease from chick brain extracellular matrix

1992 • 86 citations

Multiple forms of ubiquitin-activating enzyme E1 from wheat. Identification of an essential cysteine by in vitro mutagenesis.

1992 • 78 citations

The neural cell adhesion molecule (NCAM) heparin binding domain binds to cell surface heparan sulfate proteoglycans

1992 • 76 citations

Cloning of ubiquitin activating enzyme from wheat and expression of a functional protein in Escherichia coli.

1990 • 69 citations

Assignment of the Human Aggrecan Gene (AGC1) to 15q26 Using Fluorescence in Situ Hybridization Analysis

1993 • 65 citations

Enzymatic amplification of specific cDNA inserts from λgt11 libraries

1988 • 53 citations

An improved procedure for the purification of protein fused with glutathione S-transferase.

1992 • 51 citations

Cellular signaling: new insights into the action of the plant growth hormone auxin.

1993 • 43 citations

Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer's disease

1992 • 40 citations

Cloning and sequence of a functionally active cDNA encoding the mouse ubiquitin-activating enzyme E1

1992 • 24 citations

Localization of human CREBBP (CREB Binding Protein) to 16p13.3 by fluorescence in situ hybridization

1995 • 10 citations

Multiplexed minipreps for rapid screening of large numbers of recombinant DNA clones.

1993 • 3 citations