Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor

1990 • 1,388 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene

1991 • 1,191 citations

The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21

1987 • 1,149 citations

A mutation in the Amyloid Precursor Protein Associated with Hereditary Alzheimer's Disease

1991 • 1,121 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

1990 • 895 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

Linkage studies in familial Alzheimer disease: evidence for chromosome 19 linkage.

1991 • 762 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Molecular cloning and characterization of a cDNA encoding the cerebrovascular and the neuritic plaque amyloid peptides.

1987 • 589 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Alzheimer amyloid protein precursor complexes with brain GTP-binding protein Go

1993 • 430 citations

G0 is a major growth cone protein subject to regulation by GAP-43

1990 • 422 citations

Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

1990 • 396 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene

1992 • 275 citations

A locus for familial early–onset Alzhelmer's disease on the long arm of chromosome 14, proximal to the α1–antichymotrypsin gene

1992 • 267 citations

Absence of Linkage of Chromosome 21q21 Markers to Familial Alzheimer's Disease

1988 • 245 citations

Identification and differential expression of a novel alternative splice isoform of the beta A4 amyloid precursor protein (APP) mRNA in leukocytes and brain microglial cells.

1992 • 215 citations

A Drosophila gene encoding a protein resembling the human beta-amyloid protein precursor.

1989 • 212 citations

A Novel mRNA of the A4 Amyloid Precursor Gene Coding for a Possibly Secreted Protein

1989 • 209 citations

Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases.

1992 • 191 citations

Identification, secretion, and neural expression of APPL, a Drosophila protein similar to human amyloid protein precursor

1990 • 141 citations

Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter

1991 • 80 citations

Localization of the putative precursor of Alzheimer's disease-specific amyloid at nuclear envelopes of adult human muscle.

1988 • 76 citations

Familial Alzheimer's disease: Progress and problems

1989 • 67 citations

The Amyloid Precursor-like Protein (APLP) Gene Maps to the Long Arm of Human Chromosome 19

1993 • 56 citations

Characterization of cDNA encoding a human sperm membrane protein related to A4 amyloid protein.

1990 • 54 citations

β-Amyloid precursor protein localization in the Golgi apparatus in neuron and oligodendrocytes. An immunocytochemical structural and ultrastructural study in normal and axotomized neurons

1992 • 53 citations

A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs

1991 • 51 citations

Cellular specificity and regional distribution of amyloid β protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation

1993 • 37 citations

A Go-like protein in Drosophila melanogaster and its expression in memory mutants.

1990 • 36 citations

Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques

1993 • 24 citations

Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20

1991 • 15 citations

Linkage studies in familial Alzheimer's disease

1990 • 14 citations

Studies of Amyloid β‐Protein Precursor Expression in Alzheimer's Disease

1991 • 11 citations