Distinct Functions of CD8(CD4) are Utilized at Different Stages of T‐Lymphocyte Differentiation

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Cytochemical Identification of Monocytes and Granulocytes

1971 • 2,735 citations

Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*

1979 • 1,989 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck

1988 • 1,442 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen‐Reactivity

1983 • 1,040 citations

T-Lymphocyte Recognition of Antigen in Association with Gene Products of the Major Histocompatibility Complex

1985 • 942 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

OKT3: A monoclonal anti-human T lymphocyte antibody with potent mitogenic properties

1980 • 718 citations

T Cell Subsets and the Recognition of MHC Class

1983 • 702 citations

Characterization of a murine monoclonal antibody specific for an allotypic determinant on T cell antigen receptor.

1985 • 676 citations

The Role of the T3/Antigen Receptor Complex in T-Cell Activation

1986 • 627 citations

Expression of interleukin-2 receptors as a differentiation marker on intrathymic stem cells

1985 • 613 citations

Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions.

1982 • 600 citations

Transfer of specificity by murine α and β T-cell receptor genes

1986 • 568 citations

OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties.

1980 • 525 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

Hybrid antibodies can target sites for attack by T cells

1985 • 479 citations

MONOCLONAL ANTIBODIES TO MOUSE MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS

1982 • 471 citations

Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium.

1984 • 452 citations

On the fragmentation of monoclonal IgG1, IgG2a, and IgG2b from BALB/c mice.

1983 • 417 citations

The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype.

1984 • 389 citations

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines.

1983 • 377 citations

Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues

1982 • 359 citations

Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen

1987 • 348 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

The major histocompatibility complex-restricted antigen receptor on T cells. II. Role of the L3T4 product.

1983 • 325 citations

Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man.

1981 • 304 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Specific antigen—la activation of transfected human T cells expressing murine Ti αβ —human T3 receptor complexes

1987 • 247 citations

Characterization of murine thymocytes with CDS-associated T-cell receptor structures

1987 • 245 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

Reconstitution of MHC class I specificity by transfer of the T cell receptor and Lyt-2 genes

1987 • 220 citations

Cloned T Lymphocytes and Monoclonal Antibodies as Probes for Cell Surface Molecules Active in T Cell‐Mediated Cytolysis

1982 • 219 citations

Cytotoxic T cells: Lyt phenotype and blocking of killing activity by Lyt antisera

1979 • 208 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Selective inhibition of human T cell cytotoxicity at levels of target recognition or initiation of lysis by monoclonal OKT3 and Leu-2a antibodies.

1982 • 185 citations

Transfection of the CD8 gene enhances T-cell recognition

1987 • 177 citations

Antigen‐specific cytotoxic T cell and antigen‐specific proliferating T cell clones can be induced to cytolytic activity by monoclonal antibodies against T3

1985 • 175 citations

Qat-4 and Qat-5, new murine T-cell antigens governed by the Tla region and identified by monoclonal antibodies.

1979 • 173 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

Signal transduction through cd4 receptors: stimulatory vs. inhibitory activity is regulated by cd4 proximity to the cd31t cell receptor

1988 • 166 citations

Major histocompatibility complex antigen expression on the epithelium of the developing thymus in normal and nude mice.

1981 • 165 citations

Synergism in the activation of human CD8 T cells by cross-linking the T-cell receptor complex with the CD8 differentiation antigen.

1986 • 159 citations

Lymphoid Cell Surface Interaction Structures Detected Using Cytolysis‐Inhibiting Monoclonal Antibodies

1982 • 155 citations

Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus.

1979 • 146 citations

Cross-linking of T3 (CD3) with T4 (CD4) enhances the proliferation of resting T lymphocytes.

1987 • 136 citations

Effective activation of resting mouse T lymphocytes by cross‐linking submitogenic concentrations of the T cell antigen receptor with either Lyt‐2 or L3T4

1987 • 120 citations

Cross‐linking of the T cell receptor complex with the subset‐specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells

1987 • 117 citations

A speculative view of the multicomponent nature of T cell antigen recognition

1986 • 117 citations

Molecular linkage of the Ly-3 and Ly-2 genes. Requirement of Ly-2 for Ly-3 surface expression.

1988 • 101 citations

Inhibition of T cell-mediated cytolysis by monoclonal antibodies directed against Lyt-2: heterogeneity of inhibition at the clonal level.

1981 • 94 citations

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

1987 • 89 citations

Evidence for an association between CD8 molecules and the T cell receptor complex on cytotoxic T cells.

1987 • 83 citations

Quantitative studies on T cell diversity. I. Determination of the precursor frequencies for two types of streptococcus A-specific helper cells in nonimmune, polyclonally activated splenic T cells.

1980 • 75 citations

Accessory cell function in the Con A response: role of Ia-positive and Ia-negative accessory cells.

1985 • 72 citations

Expression and role of the T cell receptor in early thymocyte differentiation in vitro.

1987 • 66 citations

Activation of T cells by cross‐linking an anti‐CD3 antibody with a second anti‐T cell antibody: mechanism and subset‐specific activation

1987 • 64 citations

Expression and function of CD8 in a murine T cell hybridoma.

1987 • 63 citations

Lysis of anti-T3-bearing murine hybridoma cells by human allospecific cytotoxic T cell clones and inhibition of that lysis by anti-T3 and anti-LFA-1 antibodies.

1985 • 59 citations

Aged murine killer T-cell clones acquire specific cytotoxicity for P815 mastocytoma cells

1984 • 56 citations

Network regulation among T cells; Conclusions from limiting dilution experiments

1983 • 54 citations

Quantitative studies on T cell diversity. II. Determination of the frequencies and Lyt phenotypes of two types of precursor cells for alloreactive cytotoxic T cells in polyclonally and specifically activated splenic T cells.

1981 • 53 citations

Selective activation of Lyt 2+ precursor T cells by ligation of the antigen receptor

1985 • 51 citations

Network Regulation among T Cells: Qualitative and Quantitative Studies on Suppression in the Non‐Immune State

1984 • 49 citations

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells.

1984 • 47 citations

Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation.

1986 • 41 citations

Effects of Anti‐Lyt Antibodies on T‐Cell Functions*

1982 • 36 citations

The influence of valence on the functional activities of monoclonal anti-L3T4 antibodies. Discrimination of signaling from other effects.

1987 • 34 citations

Con A-induced TCGF-reactivity is selectively acquired by Lyt-2-positive T cell precursors.

1983 • 27 citations

The semiotics of cellular communication in the immune system

1989 • 24 citations

The T cell‐specific serine proteinase TSP‐1 is associated with cytoplasmic granules of cytolytic T lymphocytes

1987 • 24 citations

Heterologous cross-linking of Lyt-2 (CD8) to the alpha beta-T cell receptor is more effective in T cell activation than homologous alpha beta-T cell receptor cross-linking.

1988 • 20 citations

Immunoregulation through CD8 (Ly‐2): state of aggregation with the α/β/CD3 T cell receptor controls interleukin 2‐dependent T cell growth

1989 • 20 citations

Antibodies to the L3T4 and Lyt-2 molecules interfere with antigen receptor-driven activation of cloned murine T cells.

1987 • 19 citations

Selective stimulation of human t lymphocyte subsets by heteroconjugates of antibodies to the t cell receptor and to subset-specific differentiation antigens

1988 • 19 citations

The mechanism of anti-Lyt-2 inhibition of antibody-directed lysis by cytotoxic T lymphocytes.

1987 • 18 citations

The role of T-cell receptor α and β genes in MHC-restricted antigen recognition

1986 • 17 citations

Role of accessory molecules in signal transduction of cytolytic T lymphocyte by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies.

1987 • 14 citations

Involvement of the T cell antigen receptor and of Lyt-2 in the cytotoxic function of aged killer (AK) T cells.

1986 • 12 citations

Role of CD8 (Lyt‐2) in Cytotoxic T‐Cell Function

1988 • 6 citations

Selective induction of T-cell subsets by antibodies to the T-cell antigen receptor and to the subset-specific differentiation antigens CD8 and CD4

1988 • 4 citations

Loss of Antigen Recognition and Impaired Cytolytic Function in Most Hybrids between Cytotoxic T Cells and BW5147

1987 • 3 citations