A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections

NATURAL KILLER CELLS IN ANTIVIRAL DEFENSE: Function and Regulation by Innate Cytokines

1999 • 2,128 citations

Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection

1998 • 1,996 citations

Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

1997 • 1,172 citations

Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice

1998 • 914 citations

Massive Expansion of Antigen-Specific CD8+ T Cells during an Acute Virus Infection

1998 • 794 citations

Translator's Introduction

2001 • 786 citations

Induction and Exhaustion of Lymphocytic Choriomeningitis Virus–specific Cytotoxic T Lymphocytes Visualized Using Soluble Tetrameric Major Histocompatibility Complex Class I–Peptide Complexes

1998 • 733 citations

Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii.

1994 • 729 citations

IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB

1997 • 726 citations

Interferons α and β as Immune Regulators—A New Look

2001 • 671 citations

Interferon‐γ‐inducing factor enhances T helper 1 cytokine production by stimulated human T cells: synergism with interleukin‐12 for interferon‐γ production

1996 • 606 citations

IFN-gamma-inducing factor (IGIF) is a costimulatory factor on the activation of Th1 but not Th2 cells and exerts its effect independently of IL-12.

1997 • 528 citations

Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons.

1998 • 486 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Interleukin-18: A Novel Cytokine That Augments Both Innate and Acquired Immunity

1998 • 458 citations

Characterization of early IL-12, IFN-alphabeta, and TNF effects on antiviral state and NK cell responses during murine cytomegalovirus infection.

1996 • 413 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance.

1990 • 372 citations

Interferons and Other Cytokines

1997 • 364 citations

Interleukin-18

1999 • 361 citations

Role of early cytokines, including alpha and beta interferons (IFN-α\β), in innate and adaptive immune responses to viral infections

1998 • 338 citations

Cross-reactivities in memory cytotoxic T lymphocyte recognition of heterologous viruses.

1994 • 317 citations

Interferon-α/β inhibition of interleukin 12 and interferon-γ productionin vitroand endogenously during viral infection

1997 • 303 citations

Two Roads Diverged: Interferon α/β– and Interleukin 12–mediated Pathways in Promoting T Cell Interferon γ Responses during Viral Infection

1999 • 299 citations

Cutting Edge: IL-12 Is Required for the Maintenance of IFN-γ Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen,Toxoplasma gondii

2000 • 296 citations

Interferon α/β-mediated inhibition and promotion of interferon γ: STAT1 resolves a paradox

2000 • 293 citations

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation

2001 • 277 citations

Influenza A virus-induced IFN-alpha/beta and IL-18 synergistically enhance IFN-gamma gene expression in human T cells.

1998 • 272 citations

Initial and innate responses to viral infections — pattern setting in immunity or disease

1999 • 241 citations

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

2001 • 237 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Effects of IL-12 on the response and susceptibility to experimental viral infections.

1994 • 233 citations

Interferon-γ Is Essential for Destruction of β Cells and Development of Insulin-dependent Diabetes Mellitus

1997 • 220 citations

Influenza A Virus-Induced IFN-α/β and IL-18 Synergistically Enhance IFN-γ Gene Expression in Human T Cells

1998 • 218 citations

IL-12 Is Required to Maintain a Th1 Response DuringLeishmania majorInfection

2000 • 207 citations

Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation

1999 • 202 citations

The Proximal Regulatory Element of the Interferon-γ Promoter Mediates Selective Expression in T Cells

1996 • 200 citations

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2

2000 • 190 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Cutting Edge: Selective IL-18 Requirements for Induction of Compartmental IFN-γ Responses During Viral Infection

2000 • 185 citations

IFN-α and IL-12 Induce IL-18 Receptor Gene Expression in Human NK and T Cells

2000 • 169 citations

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells

1999 • 168 citations

Fine dissection of a nine amino acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class I-restricted H-2Db cytotoxic T lymphocytes.

1988 • 166 citations

Identification of Db- and Kb-Restricted Subdominant Cytotoxic T-Cell Responses in Lymphocytic Choriomeningitis Virus-Infected Mice

1998 • 164 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

NK cell functions restrain T cell responses during viral infections

2001 • 140 citations

Persistent Virus Infection despite Chronic Cytotoxic T-Lymphocyte Activation in Gamma Interferon-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus

2000 • 136 citations

Vaccination and protection from a lethal viral infection: Identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope

1990 • 132 citations

Comparison of the effects of interleukin‐1α, interleukin‐lβ and interferon‐γ‐inducing factor on the production of interferon‐γ by natural killer

1997 • 130 citations

The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-γ Promoter in T Cells

1998 • 128 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice.

1985 • 117 citations

Potential pathways for regulation of NK and T cell responses: differential X-linked lymphoproliferative syndrome gene product SAP interactions with SLAM and 2B4

2000 • 110 citations

Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice

1989 • 103 citations

CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

1998 • 97 citations

Secondary response to Listeria infection requires IFN-gamma but is partially independent of IL-12.

1995 • 90 citations

Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus.

1994 • 89 citations

Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon

1994 • 89 citations

CD4+ and CD8+ T Cell Interactions in IFN-γ and IL-4 Responses to Viral Infections: Requirements for IL-2

1998 • 85 citations

Virus infection induces proteolytic processing of IL-18 in human macrophages via caspase-1 and caspase-3 activation

2001 • 83 citations

Recovery from Acute Virus Infection

1988 • 70 citations

Mechanism of recovery from acute virus infection

1985 • 69 citations

Promotion of Alpha/Beta Interferon Induction during In Vivo Viral Infection through Alpha/Beta Interferon Receptor/STAT1 System-Dependent and -Independent Pathways

2002 • 67 citations

Generation of large granular T lymphocytes in vivo during viral infection.

1986 • 67 citations

T lymphocyte dynamics during Listeria monocytogenes infection

1999 • 65 citations

The immune response of the mouse to lymphocytic choriomeningitis virus

1983 • 64 citations

IFN induction and associated changes in splenic leukocyte distribution.

1993 • 62 citations

Uncovering subdominant cytotoxic T-lymphocyte responses in lymphocytic choriomeningitis virus-infected BALB/c mice

1997 • 58 citations

Enumeration of single IFN-gamma-producing cells in mice during viral and bacterial infection.

1989 • 50 citations

Compartmental Differences in NK Cell Responsiveness to IL-12 During Lymphocytic Choriomeningitis Virus Infection

2000 • 46 citations

Low-Affinity Cytotoxic T-Lymphocytes Require IFN-γ to Clear an Acute Viral Infection

1997 • 45 citations

Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic T-lymphocyte activity: implications for control of viral disease

1992 • 42 citations

Clearance of lymphocytic choriomeningitis virus in antibody- and B-cell-deprived mice

1988 • 41 citations

In Vivo Treatment with a MHC Class I-Restricted Blocking Peptide Can Prevent Virus-Induced Autoimmune Diabetes

1998 • 37 citations

Altered tissue distribution of viral replication and T cell spreading is pivotal in the protection against fatal lymphocytic choriomeningitis in mice after neutralization of IFN-alpha/beta.

1994 • 35 citations

Modulation by gamma interferon of antiviral cell-mediated immune responses in vivo

1996 • 28 citations

Use of a High-Affinity Peptide That Aborts MHC-Restricted Cytotoxic T Lymphocyte Activity against Multiple Viruses in Vitro and Virus-Induced Immunopathologic Disease in Vivo

1999 • 17 citations

The Immune Response of the Mouse to Lymphocytic Choriomeningitis Virus. II. Active Suppression of Cell-mediated Immunity by Infection with High Virus Doses

1982 • 17 citations

Deleted Work

1955 • 0 citations