Persistent Virus Infection despite Chronic Cytotoxic T-Lymphocyte Activation in Gamma Interferon-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function

1998 • 1,890 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

1993 • 1,219 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Induction of Bystander T Cell Proliferation by Viruses and Type I Interferon in Vivo

1996 • 1,077 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

CD8+ T cells clear influenza virus by perforin or Fas-dependent processes.

1997 • 493 citations

Immune function in mice lacking the perforin gene.

1994 • 474 citations

HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy

1999 • 417 citations

Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors

1995 • 353 citations

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice

1994 • 321 citations

A New Look at T Cells

1998 • 269 citations

Cytokines and immunity to viral infections

1997 • 256 citations

Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

1998 • 256 citations

A case for cytokines as effector molecules in the resolution of virus infection

1993 • 216 citations

Protective Immunity Does Not Correlate with the Hierarchy of Virus-specific Cytotoxic T Cell Responses to Naturally Processed Peptides

1998 • 210 citations

A critical role for neutralizing-antibody-producing B cells, CD4⁺T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers

1997 • 202 citations

Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice.

1996 • 185 citations

Different roles for rcytotoxic T cells in the control of infections with cytopathic versus noncytopathic viruses

1996 • 171 citations

STUDIES ON CELL-MEDIATED IMMUNITY TO LYMPHOCYTIC CHORIOMENINGITIS VIRUS IN MICE

1973 • 167 citations

Establishment and Persistence of Virus‐Specific CD4⁺ and CD8⁺ T Cell Memory

1996 • 155 citations

In vivoproliferation of naïve and memory influenza-specific CD8⁺T cells

1999 • 146 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

Major histocompatibility complex – dependent T cell epitopes of lymphocytic choriomeningitis virus nucleoprotein and their protective capacity against viral disease

1989 • 140 citations

Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes

1995 • 121 citations

CD40 Ligand-Mediated Interactions Are Involved in the Generation of Memory CD8⁺Cytotoxic T Lymphocytes (CTL) but Are Not Required for the Maintenance of CTL Memory following Virus Infection

1998 • 120 citations

Changes in cell adhesion molecule expression on T cells associated with systemic virus infection.

1994 • 113 citations

Persistence of lymphocytic choriomeningitis virus at very low levels in immune mice

1999 • 112 citations

Cytolytically active memory CTL present in lymphocytic choriomeningitis virus-immune mice after clearance of virus infection.

1997 • 97 citations

The dynamics of HTLV-I and the CTL response

1999 • 94 citations

In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection.

1989 • 93 citations

CD40 Ligand Is Pivotal to Efficient Control of Virus Replication in Mice Infected with Lymphocytic Choriomeningitis Virus

1998 • 86 citations

Role of virus and host variables in virus persistence or immunopathological disease caused by a non-cytolytic virus

1995 • 81 citations

Compromised virus control and augmented perforin-mediated immunopathology in IFN-gamma-deficient mice infected with lymphocytic choriomeningitis virus.

1999 • 78 citations

Apoptotic Regulation of T Cells and Absence of Immune Deficiency in Virus-Infected Gamma Interferon Receptor Knockout Mice

1998 • 77 citations

Compromised Virus Control and Augmented Perforin-Mediated Immunopathology in IFN-γ-Deficient Mice Infected with Lymphocytic Choriomeningitis Virus

1999 • 74 citations

Cytotoxic T Lymphocyte Control of Acute Lymphocytic Choriomeningitis Virus Infection: Interferon , but Not Tumour Necrosis Factor , Displays Antiviral Activity in vivo

1989 • 72 citations

The Role of CD4⁺ T Cells in Cell‐Mediated Immunity to LCM V: Studies in MHC Class I and Class II Deficient Mice

1994 • 71 citations

Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus‐infected mice with anti‐interferon‐γ monoclonal antibody blocks generation of virus‐specific cytotoxic T lymphocytes and virus elimination

1989 • 71 citations

Mechanism of recovery from acute virus infection

1985 • 69 citations

THE PROVOCATION OF LATENT LYMPHOCYTIC CHORIOMENINGITIS VIRUS INFECTIONS IN MICE BY TREATMENT WITH ANTILYMPHOCYTIC SERUM

1968 • 65 citations

Interferon‐γ is not an antiviral, but a growth‐promoting factor for t lymphocytes

1988 • 63 citations

Lymphocytic Choriomeningitis Virus Infection is Associated with Long‐Standing Perturbation of LFA‐1 Expression on CD8⁺ T Cells

1995 • 58 citations

Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule

1992 • 49 citations

MHC class I and non-MHC-linked capacity for generating an anti-viral CTL response determines susceptibility to CTL exhaustion and establishment of virus persistence in mice.

1994 • 49 citations

Immune Responses and Viral Phenotype: Do Replication Rate and Cytopathogenicity Influence Virus Load?

1999 • 46 citations

Low-Affinity Cytotoxic T-Lymphocytes Require IFN-γ to Clear an Acute Viral Infection

1997 • 45 citations

MHC and non-MHC genes regulate elimination of lymphocytic choriomeningitis virus and antiviral cytotoxic T lymphocyte and delayed-type hypersensitivity mediating T lymphocyte activity in parallel.

1989 • 36 citations

Virus-induced non-specific signals cause cell cycle progression of primed CD8+ T cells but do not induce cell differentiation

1999 • 31 citations

Selection of CD8+ T Cells with Highly Focused Specificity During Viral Persistence in the Central Nervous System

1999 • 28 citations

T-cell-mediated immunity to lymphocytic choriomeningitis virus in beta2-integrin (CD18)- and ICAM-1 (CD54)-deficient mice

1996 • 25 citations