CD4+ and CD8+ T cell interactions in IFN-gamma and IL-4 responses to viral infections: requirements for IL-2.

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

Acquisition of Lymphokine-Producing Phenotype by CD4+ T Cells

1994 • 1,573 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

Disruption of the murine IL-4 gene blocks Th2 cytokine responses

1993 • 1,197 citations

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

1994 • 1,161 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence.

1984 • 782 citations

Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response.

1993 • 738 citations

Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

1991 • 695 citations

Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines

1995 • 686 citations

The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

1996 • 671 citations

Cytotoxic T-cell memory without antigen

1994 • 669 citations

Generation of polarized antigen-specific CD8 effector populations: reciprocal action of interleukin (IL)-4 and IL-12 in promoting type 2 versus type 1 cytokine profiles.

1994 • 527 citations

Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes.

1995 • 517 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

Regulation of the production of immune interferon and cytotoxic T lymphocytes by interleukin 2.

1981 • 477 citations

Immune Responses in Interleukin-2-Deficient Mice

1993 • 476 citations

Requirement for natural killer cell-produced interferon gamma in defense against murine cytomegalovirus infection and enhancement of this defense pathway by interleukin 12 administration.

1995 • 458 citations

Lack of Evidence for the Dichotomy of T_H1 and T_H2 Predominance in HIV-Infected Individuals

1994 • 434 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

An absolute and restricted requirement for IL-12 in natural killer cell IFN-gamma production and antiviral defense. Studies of natural killer and T cell responses in contrasting viral infections.

1996 • 384 citations

Bone marrow is a major site of long-term antibody production after acute viral infection

1995 • 384 citations

Interleukin 2 Regulates Expression of Its Receptor and Synthesis of Gamma Interferon by Human T Lymphocytes

1984 • 350 citations

Type 1 and Type 2: a fundamental dichotomy for all T-cell subsets

1996 • 320 citations

Increased clearance of IgG in mice that lack β₂‐microglobulin: possible protective role of FcRn

1996 • 317 citations

Cytoimitiunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system

1986 • 250 citations

Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome

1995 • 249 citations

Functional analysis of T lymphocyte subsets in antiviral host defense.

1987 • 237 citations

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

1995 • 237 citations

T4+ T helper cell function in vivo: differential requirement for induction of antiviral cytotoxic T-cell and antibody responses

1988 • 205 citations

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression.

1991 • 201 citations

Mechanism of recovery from acute virus infection: treatment of lymphocytic choriomeningitis virus-infected mice with monoclonal antibodies reveals that Lyt-2+ T lymphocytes mediate clearance of virus and regulate the antiviral antibody response

1987 • 185 citations

Cytokines in the generation of immune responses to, and resolution of, virus infection

1994 • 185 citations

Endogenous IL-2 contributes to T cell expansion and IFN-gamma production during lymphocytic choriomeningitis virus infection.

1995 • 172 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses.

1992 • 160 citations

IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.

1990 • 155 citations

An Essential Role for Type 1 Interferon-γ in Terminating Persistent Viral Infection

1995 • 145 citations

Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes.

1982 • 145 citations

Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection.

1996 • 136 citations

Concurrent production of interleukin-2, interleukin-10, and gamma interferon in the regional lymph nodes of mice with influenza pneumonia

1994 • 134 citations

Interleukin 2 regulates immune interferon (IFN gamma) production by normal and suppressor cell cultures.

1982 • 107 citations

Lymphokines and the immune response: the central role of interleukin-2

1991 • 97 citations

Regulation of IFN-gamma induction in human peripheral blood cells by exogenous and endogenously produced interleukin 2.

1985 • 96 citations

Antiviral immune responses of lymphocytic choriomeningitis virus-infected mice lacking CD8+ T lymphocytes because of disruption of the beta 2-microglobulin gene

1993 • 88 citations

Beta 2-microglobulin-deficient mice can be protected against influenza A infection by vaccination with vaccinia-influenza recombinants expressing hemagglutinin and neuraminidase.

1993 • 84 citations

Effective clearance of a persistent viral infection requires cooperation between virus-specific Lyt2+ T cells and nonspecific bone marrow-derived cells

1987 • 76 citations

Fas-dependent CD4⁺cytotoxic T-cell-mediated pathogenesis during virus infection

1996 • 72 citations

Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice.

1993 • 72 citations

Generation of large granular T lymphocytes in vivo during viral infection.

1986 • 67 citations

The activation of IL-2 transcription in L3T4+ and Lyt-2+ lymphocytes during virus infection in vivo.

1989 • 66 citations

Antiviral immune responses in mice deficient for both interleukin-2 and interleukin-4

1995 • 66 citations

Phenotypic and functional analysis of the cellular response in regional lymphoid tissue during an acute virus infection.

1989 • 65 citations

Cytokine profiles of bronchoalveolar lavage cells from mice with influenza pneumonia: consequences of CD4+ and CD8+ T cell depletion.

1993 • 57 citations

Antiviral Immune Responses of Mice Lacking MHC Class II or Its Associated Invariant Chain

1996 • 55 citations

Interleukin 2 regulation of mitogen induction of immune interferon (IFNγ) in spleen cells and thymocytes

1982 • 54 citations

Enumeration of single IFN-gamma-producing cells in mice during viral and bacterial infection.

1989 • 50 citations

Interleukin 2 enhancement of lymphokine secretion by T lymphocytes: analysis of established clones and primary limiting dilution microcultures.

1984 • 48 citations

The role of CD4+ cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection.

1991 • 48 citations

IL-2-dependent NK cell responses discovered in virus-infected beta 2-microglobulin-deficient mice.

1994 • 44 citations

Aberrant T cells in beige mutant mice.

1987 • 42 citations

Natural killer cell activity in lymphocytic choriomeningitis virus-infected 2-microglobulin-deficient mice

1995 • 23 citations

Interleukin 2 and concanavalin A stimulate interferon-gamma production in a murine cytolytic T cell clone by different pathways.

1987 • 22 citations

Altered Kinetics of CD4+T Cell Proliferation and Interferon-γ Production in the Absence of CD8+T Lymphocytes in Virus-Infected β2-Microglobulin-Deficient Mice

1996 • 13 citations