Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences.

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

A RAPID BANDING TECHNIQUE FOR HUMAN CHROMOSOMES

1971 • 5,049 citations

THE STABILITY OF BROKEN ENDS OF CHROMOSOMES IN ZEA MAYS

1941 • 1,586 citations

CHROMOSOME ORGANIZATION AND GENIC EXPRESSION

1951 • 1,174 citations

A tandemly repeated sequence at the termini of the extrachromosomal ribosomal RNA genes in Tetrahymena

1978 • 1,003 citations

Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells.

1978 • 972 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

Microfluorometric Detection of Deoxyribonucleic Acid Replication in Human Metaphase Chromosomes

1973 • 838 citations

Cloning yeast telomeres on linear plasmid vectors

1982 • 625 citations

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control

1976 • 518 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase

1978 • 426 citations

The remaking of chromosomes

1938 • 416 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line.

1978 • 393 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary DNA gene

1982 • 356 citations

Optical studies of the interaction of 33258 Hoechst with DNA, chromatin, and metaphase chromosomes

1975 • 349 citations

The Fusion of Broken Ends of Chromosomes Following Nuclear Fusion

1942 • 321 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells.

1979 • 185 citations

Structure of amplified normal and variant dihydrofolate reductase genes in mouse sarcoma S180 cells.

1982 • 184 citations

Methotrexate-resistant Chinese hamster ovary cells have amplified a 135-kilobase-pair region that includes the dihydrofolate reductase gene.

1981 • 175 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Chromosome stability in CHO cells

1977 • 155 citations

Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression.

1982 • 145 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Relationship of amplified dihydrofolate reductase genes to double minute chromosomes in unstably resistant mouse fibroblast cell lines.

1981 • 127 citations

Telomere replication, kinetochore organizers, and satellite DNA evolution.

1979 • 113 citations

Chromosomal and Extrachromosomal Localization of Amplified Dihydrofolate Reductase Genes in Cultured Mammalian Cells

1981 • 112 citations

Enhancement of banding patterns in human metaphase chromosomes by energy transfer

1978 • 106 citations

On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages.

1981 • 104 citations

Phenotype stabilisation and integration of transferred material in chromosome-mediated gene transfer

1979 • 104 citations

Antifolate-resistant Chinese hamster cells. Evidence for dihydrofolate reductase gene amplification among independently derived sublines overproducing different dihydrofolate reductases.

1980 • 100 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability.

1981 • 80 citations

Double Minutes in Human Carcinoma Cell Lines, With Special Reference to Breast Tumors<xref ref-type="fn" rid="fn2">2</xref>

1979 • 78 citations

Optical studies of complexes of quinacrine with DNA and chromatin: implications for the fluorescence of cytological chromosome preparations

1974 • 74 citations

Gene amplification in methotrexate-resistant mouse cells

1981 • 66 citations

Cloning of DNA from double minutes of Y1 mouse adrenocortical tumor cells: Evidence for gene amplification

1981 • 56 citations

Construction of a Modular Dihydrofolate Reductase cDNA Gene: Analysis of Signals Utilized for Efficient Expression

1982 • 51 citations

In vitro translation of hypoxanthine/guanine phosphoribosyltransferase mRNA: characterization of a mouse neuroblastoma cell line that has elevated levels of hypoxanthine/guanine phosphoribosyltransferase protein.

1981 • 50 citations

Aberrant double replication of segments of chromosomal DNA following DNA synthesis inhibition by cytosine arabinoside

1979 • 44 citations

Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines.

1982 • 43 citations

Amplification and Loss of Dihydrofolate Reductase Genes in a Chinese Hamster Ovary Cell Line

1981 • 42 citations

Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization

1982 • 40 citations

EVIDENCE OF CHROMOSOMAL BREAKS NEAR THE MATING-TYPE LOCUS OF SACCHAROMYCES CEREVISIAE THAT ACCOMPANY MATα x MATα MATINGS

1981 • 38 citations

RESTRICTED REJOINING OF CHROMOSOMAL SUBUNITS IN ABERRATION FORMATION: A TEST FOR SUBUNIT DISSIMILARITY

1969 • 38 citations

Replication pattern of a large homogenously staining chromosome region in antifolate‐resistant Chinese hamster cell lines

1981 • 38 citations

Relationship of Amplified Dihydrofolate Reductase Genes to Double Minute Chromosomes in Unstably Resistant Mouse Fibroblast Cell Lines

1981 • 34 citations

Banding patterns and late replication in HeLa cells

1973 • 29 citations

Deoxyribonucleic Acid-Mediated Gene Transfer in Mammalian Cells: Molecular Analysis of Unstable Transformants and Their Progression to Stability

1981 • 28 citations

Double minutes in human large bowel cancer

1980 • 26 citations

The chromosomal aberraation of double-minutes in three gliomas

1970 • 25 citations

Variable Content of Double Minute Chromosomes Is Not Correlated with Degree of Phenotype Instability in Methotrexate-Resistant Human Cell Lines

1982 • 16 citations

Chromosome structure and DNA sequence alterations associated with mutation of transformed genes.

1981 • 14 citations