Structure of DNA formed in the first step of CAD gene amplification.

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

1979 • 3,525 citations

Advanced bacterial genetics

1980 • 2,388 citations

Plasmid screening at high colony density

1980 • 1,100 citations

Gene amplification in cultured animal cells

1984 • 639 citations

GENE AMPLIFICATION

1984 • 580 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

The construction of cosmid libraries which can be used to transform eukaryotic cells

1982 • 319 citations

Isolation of β-globin-related genes from a human cosmid library

1981 • 277 citations

Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis

1976 • 228 citations

Diazotizable arylamine cellulose papers for the coupling and hybridization of nucleic acids

1982 • 218 citations

N-(Phosphonacetyl)-l-Aspartate, a Potent Transition State Analog Inhibitor of Aspartate Transcarbamylase, Blocks Proliferation of Mammalian Cells in Culture

1974 • 217 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Novel DNA rearrangements are associated with dihydrofolate reductase gene amplification.

1984 • 90 citations

Differential amplification, assembly, and relocation of multiple DNA sequences in human neuroblastomas and neuroblastoma cell lines.

1985 • 81 citations

Structure of Amplified DNA in Different Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 75 citations

Structure of the Gene for CAD, the Multifunctional Protein That Initiates UMP Synthesis in Syrian Hamster Cells

1982 • 69 citations

Construction of a cDNA to the Hamster CAD Gene and Its Application Toward Defining the Domain for Aspartate Transcarbamylase

1985 • 64 citations

Co-Amplification of rRNA Genes with CAD Genes in N-(Phosphonacetyl)-L-Aspartate-Resistant Syrian Hamster Cells

1983 • 54 citations

Moderate-Level Gene Amplification in Methotrexate-Resistant Chinese Hamster Ovary Cells is Accompanied by Chromosomal Translocations At or Near the Site of the Amplified DHFR Gene

1984 • 51 citations

Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate.

1983 • 48 citations

General Method for Cloning Amplified DNA by Differential Screening with Genomic Probes

1982 • 47 citations

Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization

1982 • 40 citations

Isolation and characterization of β- and γ-crystallin genes from rat genomic cosmid libraries

1984 • 39 citations

Chromosomal Alterations Associated with Overproduction of Asparagine Synthetase in Albizziin-Resistant Chinese Hamster Ovary Cells

1983 • 35 citations

Gene amplification in methotrexate-resistant mouse cells. IV. Different DNA sequences are amplified in different resistant lines

1982 • 32 citations

Properties of dispersed, highly repeated DNA within and near the hamster CAD gene.

1982 • 18 citations

Properties of Single-Step Mutants of Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 17 citations

Properties of Dispersed, Highly Repeated DNA Within and Near the Hamster CAD Gene

1982 • 6 citations