Autonomously replicating episomes contain mdr1 genes in a multidrug-resistant human cell line.

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

A rapid method for the identification of plasmid desoxyribonucleic acid in bacteria

1978 • 941 citations

Electrophoretic Separations of Large DNA Molecules by Periodic Inversion of the Electric Field

1986 • 920 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Supercoiled loops and eucaryotic DNA replication

1980 • 626 citations

Loss of alleles at loci on human chromosome 11 during genesis of Wilms' tumour

1984 • 538 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

New method for mapping genes in human chromosomes

1975 • 356 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Double minute chromosomes can be produced from precursors derived from a chromosomal deletion.

1988 • 236 citations

Direct detection of more than 50% of the Duchenne muscular dystrophy mutations by field inversion gels

1987 • 192 citations

Enhancement of Methotrexate Resistance and Dihydrofolate Reductase Gene Amplification by Treatment of Mouse 3T6 Cells with Hydroxyurea

1983 • 191 citations

DNA Sequence Amplification in Mammalian Cells

1984 • 181 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

1987 • 137 citations

Amplified human MYC oncogenes localized to replicating submicroscopic circular DNA molecules.

1988 • 137 citations

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea.

1983 • 118 citations

Double Minute Chromosomes Can Be Produced from Precursors Derived from a Chromosomal Deletion

1988 • 112 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

The analysis of malignancy by cell fusion. VIII. evidence for the intervention of an extra-chromosomal element

1977 • 82 citations

Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin.

1987 • 80 citations

Sequence complexity of circular Epstein-Bar virus DNA in transformed cells

1981 • 79 citations

Molecular mechanism of multidrug resistance in tumor cells.

1987 • 66 citations

Circular DNA of 3T6R50 double minute chromosomes

1988 • 65 citations

Formation of an inverted duplication can be an initial step in gene amplification.

1988 • 65 citations

Double minutes replicate once during S phase of the cell cycle

1980 • 65 citations

Evolution of karyotypic abnormalities and C-MYC oncogene amplification in human colonic carcinoma cell lines

1985 • 54 citations

Chromosomal changes without DNA overproduction in hydroxyurea-treated mammalian cells: implications for gene amplification.

1986 • 52 citations

Homogeneously Staining Regions and Double Minute Chromosomes, Prevalent Cytogenetic Abnormalities of Human Neuroblastoma Cells

1983 • 52 citations

Evidence for selection of homogeneously staining regions in a human melanoma cell line.

1984 • 30 citations

Formation of an Inverted Duplication Can Be an Initial Step in Gene Amplification

1988 • 20 citations