Characterization of an Episome Produced in Hamster Cells that Amplify a Transfected CAD Gene at High Frequency: Functional Evidence for a Mammalian Replication Origin

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Hybridization of nucleic acids immobilized on solid supports

1984 • 1,357 citations

The replication of DNA in Escherichia coli

1958 • 1,202 citations

A rapid method for the identification of plasmid desoxyribonucleic acid in bacteria

1978 • 941 citations

GENE AMPLIFICATION

1984 • 580 citations

Identification and Characterization of Large Plasmids in Rhizobium meliloti using Agarose Gel Electrophoresis

1979 • 574 citations

Genetic and physical linkage of exogenous sequences in transformed cells

1980 • 486 citations

Detection of viral sequences of low reiteration frequency by in situ hybridization.

1978 • 458 citations

Aspartate Transcarbamylase

1971 • 422 citations

DOUBLE MINUTES AND HOMOGENEOUSLY STAINING REGIONS: Gene Amplification in Mammalian Cells

1982 • 357 citations

Isolation of Mutants of an Animal Virus in Bacteria

1980 • 341 citations

Transforming DNA integrates into the host chromosome

1981 • 311 citations

Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons.

1981 • 293 citations

Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis

1984 • 270 citations

The organization and amplification of two chromosomal domains containing drosophila chorion genes

1981 • 260 citations

Overreplication and recombination of DNA in higher eukaryotes: potential consequences and biological implications.

1986 • 242 citations

Double Minute Chromosomes and the Homogeneously Staining Regions in Chromosomes of a Human Neuroblastoma Cell Line

1977 • 195 citations

Double minutes in human tumor cells

1982 • 194 citations

Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells.

1981 • 190 citations

Gene amplification in a single cell cycle in Chinese hamster ovary cells.

1984 • 190 citations

Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: Possible mechanisms and relevance to tumor promotion

1981 • 171 citations

Large inverted duplications are associated with gene amplification

1986 • 147 citations

Effect of chromosomal position on amplification of transfected genes in animal cells

1984 • 140 citations

Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line.

1981 • 139 citations

Homologous recombination in mammalian cells mediates formation of a functional gene from two overlapping gene fragments.

1983 • 129 citations

Stable Amplified DNA in Drug-Resistant Leishmania Exists as Extrachromosomal Circles

1986 • 124 citations

Unstable amplification of an altered dihydrofolate reductase gene associated with double-minute chromosomes

1981 • 120 citations

Isolation of the origin of replication associated with the amplified Chinese hamster dihydrofolate reductase domain.

1986 • 116 citations

Cloning of the initiation region of a mammalian chromosomal replicon

1983 • 110 citations

Construction and functional characterization of polyomavirus genomes that separately encode the three early proteins

1984 • 108 citations

Localization of a cis-acting element responsible for the developmentally regulated amplification of drosophila chorion genes

1984 • 106 citations

The cloning and reintroduction into animal cells of a functional CAD gene, a dominant amplifiable genetic marker

1981 • 104 citations

Ultrastructural features of minute chromosomes in a methotrexate-resistant mouse 3T3 cell line

1985 • 91 citations

Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization.

1982 • 91 citations

Sequence complexity of circular Epstein-Bar virus DNA in transformed cells

1981 • 79 citations

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

1977 • 78 citations

L1 sequences in HeLa extrachromosomal circular DNA: evidence for circularization by homologous recombination.

1985 • 76 citations

Structure of Amplified DNA in Different Syrian Hamster Cell Lines Resistant to N-(Phosphonacetyl)-L-Aspartate

1983 • 75 citations

High-level, unstable adriamycin resistance in a Chinese hamster mutant cell line with double minute chromosomes.

1984 • 67 citations

A chromosome inversion alters the pattern of specific DNA replication in drosophila follicle cells

1981 • 66 citations

Double minutes replicate once during S phase of the cell cycle

1980 • 65 citations

Germ line transmission of autonomous genetic elements in transgenic mouse strains

1986 • 59 citations

A repetitive DNA family (Sau3A family) in human chromosomes: extrachromosomal DNA and DNA polymorphism.

1986 • 56 citations

High resolution analysis of the timing of replication of specific DNA sequences during S phase of mammalian cells

1983 • 56 citations

High-frequency structural gene deletion as the basis for functional hemizygosity of the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells.

1983 • 56 citations

The proposed origin of double minutes from Homogeneously Staining Region (HSR)-marker chromosomes in human neuroblastoma hybrid cell lines

1980 • 49 citations

Amplification and excision of integrated polyoma DNA sequences require a functional origin of replication

1984 • 46 citations

Theories and models in cellular transformation

1985 • 23 citations

Selective trapping of circular double-stranded DNA molecules in solidifying agarose

1982 • 22 citations

Unstable expression and amplification of a transfected oncogene in confluent and subconfluent cells.

1985 • 20 citations